Cortical, Spinal, Sacral, and Peripheral Neuromodulations as Therapeutic Approaches for the Treatment of Lower Urinary Tract Symptoms in Multiple Sclerosis Patients: A Review

Pericolini, Martina; Miget, Gabriel; Hentzen, Claire; Agrò, Enrico Finazzi; Chesnel, C.; Lagnau, Philippe; Haddad, Rebecca; Grasland, Matthieu; Amarenco, G.

doi:10.1111/ner.13525

Cited by 5 publications

(5 citation statements)

References 53 publications

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“…19 According to a review by Pericolini et al, spinal cord stimulation (SCS) and TMS for treating lower tract symptoms in MS patients were effective despite a small number of studies. 20 El-Habashy et al, saw that cortical as well as sacral magnetic stimulation showed a significant effect on lower urinary tract dysfunction in MS patients with underactive bladder rather than overactive bladder. 21 Vacher et al, collected data from the literature and found that TMS may have a role in the management of pelvic and perineal disorders.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Effect of rTMS on urinary incontinence in major vascular neurocognitive disorder

Ni,

Ke,

Tian

et al. 2024

F1000Res

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Background Urinary incontinence (UI) was an intractable symptom and many efforts had been made to combat this symptom over the past decades. Repetitive transcranial magnetic stimulation (rTMS) was used in many diseases for its focusing on neural network regulation. However, rTMS on the cortical urination center for acting on urination process remained further study. Case report A 67-year-old female farmer suffered from UI over two weeks. She was diagnosed with major vascular neurocognitive disorder. The patient received rTMS on the bilateral paracentral lobule. Stimulation was administered at 20 Hz with 25 stimulation trains of 30 stimuli each with a 30-second intertrain interval. After a 5-day course of rTMS intervention, the patient reported full awareness of her urination, but her neurocognitive decline had not improved at all. Conclusions In this case of UI with major vascular neurocognitive disorder, rTMS on the bilateral paracentral lobule was applied and therapeutic effect on UI was obvious.

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Section: Discussionmentioning

confidence: 99%

Case Report: Effect of rTMS on urinary incontinence in major vascular neurocognitive disorder

Ni,

Ke,

Tian

et al. 2024

F1000Res

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“…The micturition cycle involves a combination of reflex actions and conscious control [7]. Positioned within the frontal cortex, the cortical micturition control center regulates the filling phase.…”

Section: Multiple Sclerosis and Bladder Functionmentioning

confidence: 99%

“…Despite these minor drawbacks, PTNS is increasingly recognized for its efficacy, safety, and lack of associated side effects. However, patient selection plays a crucial role in achieving optimal therapeutic outcomes, with emphasis placed on factors such as compliance, autonomy, and cognitive abilities [7]. Despite its apparent effectiveness in alleviating bothersome symptoms like urgency in over 80% of treated patients, caution is warranted due to the limited sample size and potential bias risk in the referenced studies [21].…”

Section: Ptns Side Effects and Limitationsmentioning

confidence: 99%

“…This innovative approach not only proves to be well tolerated and safe but also addresses the logistical challenges associated with maintenance therapy, potentially reducing the need for frequent hospital visits. Therefore, while PTNS holds significant promise, further research is essential to comprehensively evaluate its efficacy and safety profile [7].…”

Section: Ptns Side Effects and Limitationsmentioning

confidence: 99%

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Posterior Tibial Nerve Stimulation for the Treatment of Detrusor Overactivity in Multiple Sclerosis Patients: A Narrative Review

Sapouna,

Zikopoulos,

Thanopoulou

et al. 2024

JPM

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Bladder dysfunction, particularly neurogenic detrusor overactivity (DO), poses a substantial challenge in multiple sclerosis (MS) patients, detrimentally impacting their quality of life (QoL). Conventional therapies often fall short, necessitating alternative approaches like posterior tibial nerve stimulation (PTNS) for effective management. This narrative review critically examines the application of PTNS in treating DO among MS patients, aiming to provide a comprehensive synthesis of its efficacy, underlying mechanisms, and clinical outcomes. By evaluating a spectrum of studies, including randomized controlled trials and long-term follow-up research, the review elucidates PTNS’s role in enhancing bladder control and ameliorating symptoms of urgency and incontinence, thereby improving patient well-being. Despite its potential, the review acknowledges the limited scope of existing research specific to MS-induced neurogenic DO and calls for further investigation to optimize PTNS protocols and understand its long-term benefits. Highlighting PTNS’s minimal invasiveness and favorable safety profile, the review advocates for its consideration as a viable third-line treatment option in MS-related bladder dysfunction management. Through this analysis, the review contributes to the broader narrative of seeking effective, patient-centered therapeutic strategies for MS-related complications, underscoring the importance of personalized care in improving patient outcomes.

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“…

opment of various "electroceuticals" far beyond familiar heart pacemakers and cochlear implants. [2,3] Deep brain, spinal cord, sacral and vagus nerves, and transcutaneous electrical nerve stimulators are now applied for the treatment of chronic pain, [4] restoration of sensory and motor function, [5] treatment of Parkinson's disease, [6] various urinary symptoms, [7] inflammatory disorders of joints and gastrointestinal tract, migraine, and other headaches. [8] U.S. Food and Drug Administration approves new electroceutical systems from market leaders and startup companies every month.

…”

mentioning

confidence: 99%

Gentle Patterning Approaches toward Compatibility with Bio‐Organic Materials and Their Environmental Aspects

Grebenko

Motovilov

Bubis

et al. 2022

Small

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Advances in material science, bio-electronic, and implantable medicine combined with recent requests for eco-friendly materials and technologies inevitably formulate new challenges for nano-and micro-patterning techniques. Overall, the importance of creating micro and nanostructures is motivated by a large manifold of fundamental and applied properties accessible only at the nanoscale. Lithography is a crucial family of fabrication methods to create prototypes and produce devices on an industrial scale. The pure trend in the miniaturization of critical electronic semiconducting components is recently enhanced by implementing bio-organic systems in electronics. So far, significant efforts have been made to find novel lithographic approaches and develop old ones to reach compatibility with delicate bio-organic systems and minimize the impact on the environment. Herein, we briefly review such delicate materials and sophisticated patterning techniques.

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Cortical, Spinal, Sacral, and Peripheral Neuromodulations as Therapeutic Approaches for the Treatment of Lower Urinary Tract Symptoms in Multiple Sclerosis Patients: A Review

Cited by 5 publications

References 53 publications

Case Report: Effect of rTMS on urinary incontinence in major vascular neurocognitive disorder

Case Report: Effect of rTMS on urinary incontinence in major vascular neurocognitive disorder

Posterior Tibial Nerve Stimulation for the Treatment of Detrusor Overactivity in Multiple Sclerosis Patients: A Narrative Review

Gentle Patterning Approaches toward Compatibility with Bio‐Organic Materials and Their Environmental Aspects

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