2016
DOI: 10.1016/j.celrep.2015.12.026
|View full text |Cite
|
Sign up to set email alerts
|

Cortical Sensory Responses Are Enhanced by the Higher-Order Thalamus

Abstract: In the mammalian brain, thalamic signals reach the cortex via two major routes: primary and higher-order thalamocortical pathways. While primary thalamocortical nuclei transmit sensory signals from the periphery, the function of higher-order thalamocortical projections remains enigmatic, in particular their role in sensory processing in the cortex. Here, by optogenetically controlling the thalamocortical pathway from the higher-order posteromedial thalamic nucleus (POm) during whisker stimulation, we demonstra… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

6
77
0

Year Published

2017
2017
2020
2020

Publication Types

Select...
5
2
2

Relationship

1
8

Authors

Journals

citations
Cited by 76 publications
(83 citation statements)
references
References 36 publications
(78 reference statements)
6
77
0
Order By: Relevance
“…While both claustrum and associative thalamic structures, such as the pulvinar nucleus, innervate the cortex and exhibit transient responses to visual stimuli in monkeys (Remedios et al 2010; Petersen et al 1985), how these structures innervate and influence cortical activity may differ. Our results demonstrate that claustrum transiently drives PtA neuron firing, whereas associative thalamic synapses onto cortical neurons provides a modulatory input in rodents (Cruikshank et al 2012; Mease et al 2016). Notably, however, studies examining thalamic afferent drive of specifically parietal cortex neurons are lacking.…”
Section: Discussionmentioning
confidence: 57%
“…While both claustrum and associative thalamic structures, such as the pulvinar nucleus, innervate the cortex and exhibit transient responses to visual stimuli in monkeys (Remedios et al 2010; Petersen et al 1985), how these structures innervate and influence cortical activity may differ. Our results demonstrate that claustrum transiently drives PtA neuron firing, whereas associative thalamic synapses onto cortical neurons provides a modulatory input in rodents (Cruikshank et al 2012; Mease et al 2016). Notably, however, studies examining thalamic afferent drive of specifically parietal cortex neurons are lacking.…”
Section: Discussionmentioning
confidence: 57%
“…However, propagation of more precise burst size information requires that cortical responses scale with thalamic burst size, which has yet to be shown. One possible approach could be combining optogenetic methods with thalamic and cortical recordings (Whitmire et al, 2016, Mease et al, 2016a, Mease et al, 2016b, Whitmire et al, 2017). …”
Section: Discussionmentioning
confidence: 99%
“…16C, blue and green lines). Monosynaptic connectivity between POm and L5tt cells was shown functionally by whole-cell recordings from L5tt cells during optogenetic activation of POm projections (Mease et al 2016a).…”
Section: Functionally Relevant Projections To L5tt Cellsmentioning
confidence: 99%