Cortical representation sites of mimic movements after facial nerve reconstruction: A functional magnetic resonance imaging study

Bitter, Thomas; Sorger, Bettina; Heßelmann, Volker; Krug, Barbara; Lackner, K.; Guntinas‐Lichius, Orlando

doi:10.1002/lary.21399

Cited by 30 publications

(17 citation statements)

References 24 publications

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“…However, these findings are purely empirical and further studies are required to understand these phenomena. Functional MRI would be the ideal tool for this purpose and its application preoperatively and postoperatively could represent the next step in the evolution of our study …”

Section: Discussionmentioning

confidence: 99%

Cross‐facial nerve graft and masseteric nerve cooptation for one‐stage facial reanimation: Principles, indications, and surgical procedure

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Cross‐facial nerve graft and masseteric nerve cooptation for one‐stage facial reanimation: Principles, indications, and surgical procedure

et al. 2013

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“…For this special situation, together with the small cortical area affected, only mild shifts of neighboring representation sites into the lip area can be expected. Bitter et al (2011) postulated that, changes in somatotopic representation of the face, lip and tongue should be present only in the motor cortex but not in the somatosensory cortex as the facial denervation affects only the motor output and not the somatosensory input. With this investigation, we demonstrated that both reorganization processes are associated.…”

Section: Figurementioning

confidence: 99%

Outcome‐dependent coactivation of lip and tongue primary somatosensory representation following hypoglossal–facial transfer after peripheral facial palsy

Rottler

Schroeder

Lotze

2012

Human Brain Mapping

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A hypoglossal-facial transfer is a common surgical strategy for reanimating the face after persistent total hemifacial palsy. We were interested in how motor recovery is associated with cortical reorganization of lip and tongue representation in the primary sensorimotor cortex after the transfer. Therefore, we used functional magnetic resonance imaging (fMRI) in 13 patients who underwent a hypoglossal-facial transfer after unilateral peripheral facial palsy. To identify primary motor and somatosensory tongue and lip representation sites, we measured repetitive tongue and lip movements during fMRI. Electromyography (EMG) of the perioral muscles during tongue and lip movements and standardized evaluation of lip elevation served as outcome parameters. We found an association of cortical representation sites in the pre- and postcentral gyrus (decreased distance of lip and tongue representation) with symmetry of recovered lip movements (lip elevation) and coactivation of the lip during voluntary tongue movements (EMG-activity of the lip during tongue movements). Overall, our study shows that hypoglossal-facial transfer resulted in an outcome-dependent cortical reorganization with activation of the cortical tongue area for restituded movement of the lip.

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“…Motor integration is increased, and functional motor integration mainly occurs in the hemisphere contralateral to the paralyzed side ( Barkhof et al, 2014 ; He et al, 2014 ; Zacà et al, 2014 ). With the gradual recovery of facial nerve function, the functional activities in the related brain regions also gradually recover to the normal level ( Rijntjes et al, 1997 ; Bitter et al, 2011 ; Wu et al, 2014 ). fMRI in the resting state (R-fMRI) is less demanding for patient cooperation than that during complex activation tasks ( Buxton, 2013 ; Conklin et al, 2014 ; Fovet et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Altered Brain Fraction Amplitude of Low Frequency Fluctuation at Resting State in Patients With Early Left and Right Bell’s Palsy: Do They Have Differences?

Han

Wang

et al. 2018

Front. Neurosci.

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Purpose: Bell’s palsy refers to acute idiopathic unilateral facial nerve palsy. It is a common disorder of the main motor pathway to the facial muscles. This study aimed to investigate the abnormal fraction amplitude of low frequency fluctuation (fALFF) of the brain in patients with early left and right Bell’s palsy.Materials and Methods: Sixty-seven patients (left 33, right 34) and 37 age- and sex-matched healthy controls underwent resting-state functional magnetic resonance imaging (R-fMRI) examination. The fALFF values were measured from all subjects and were compared among the left palsy, right palsy, and control groups. Then, correlations between the Toronto Facial Grading System (TFGS) scores of the patients and the fALFF values of abnormal brain regions were analyzed.Results: Significant group differences in fALFF values among the three groups were observed mainly in the cerebral cortical, subcortical, and deep gray matter regions. Compared with the right Bell’s palsy group, the left Bell’s palsy group showed significantly decreased fALFF values in the left temporal pole of the superior temporal gyrus (TPOsup), right supramarginal, left and right middle cingulate cortex (MCC), left superior frontal gyrus (SFG), and left precentral gyrus (PreCG), and increased fALFF values were observed in the right SFG and PreCG. Furthermore, altered fALFF values correlated positively with the TFGS scores in the left superior TPO, bilateral MCC, and right PreCG, and correlated negatively with the TFGS scores in the right SFG of the left Bell’s palsy group. Altered fALFF values correlated positively with the TFGS scores in the bilateral MCC and right PreCG and correlated negatively with the TFGS scores in the left superior TPO and SFG of the right Bell’s palsy group.Conclusion: Regulatory mechanisms seem to differ between patients with left and right early Bell’s palsy. The severity of the disease is associated with these functional alterations.

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Cortical representation sites of mimic movements after facial nerve reconstruction: A functional magnetic resonance imaging study

Abstract: Direct facial nerve repair (FNIG) leads to restoration of the original cortical activation. A cross nerve suture (HFA or HFJA) changes cortical activation and leads to different patterns of cortical activation during lip and tongue movements.

Cited by 30 publications

References 24 publications

Cross‐facial nerve graft and masseteric nerve cooptation for one‐stage facial reanimation: Principles, indications, and surgical procedure

Cross‐facial nerve graft and masseteric nerve cooptation for one‐stage facial reanimation: Principles, indications, and surgical procedure

Outcome‐dependent coactivation of lip and tongue primary somatosensory representation following hypoglossal–facial transfer after peripheral facial palsy

Altered Brain Fraction Amplitude of Low Frequency Fluctuation at Resting State in Patients With Early Left and Right Bell’s Palsy: Do They Have Differences?

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