Cortical reorganization in Bell's palsy

Klingner, Carsten M.; Volk, Gerd Fabian; Maertin, Antje; Brodoehl, Stefan; Burmeister, H; Guntinas‐Lichius, Orlando; Witte, Otto W.

doi:10.3233/rnn-2011-0592

Cited by 34 publications

(65 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is a broadly somatotopic representation of the different body parts in the primary motor cortex in an arrangement called a motor homunculus. The increased activated area on BA4 in this study corresponded to the somatotopic representation of the face primary motor cortex (M1), which was supported by a previous study on Bell's palsy [55]. In this study on cortical reorganization in Bell's palsy, patients with Bell's palsy were instructed to move the left or right mouth angle up followed by a brief relaxation of the facial muscles to regain the starting position.…”

Section: Discussionsupporting

confidence: 80%

“…In this study on cortical reorganization in Bell's palsy, patients with Bell's palsy were instructed to move the left or right mouth angle up followed by a brief relaxation of the facial muscles to regain the starting position. The activated right M1 by this motor task in reference [55] was identical to the right precentral gyrus (BA4) activated by acupuncture stimulus in this study. The other two areas of increased activation were BA6 and BA10.…”

Section: Discussionsupporting

confidence: 75%

“…Therefore, it could be suggested that the changed brain responses to acupuncture were contralateral to the palsy area. These areas contralateral to the facial palsy have also been found as the areas of overactivity when patients with Bell's palsy were performing a facial movement task and the overactivity during the mouth movement was explained by the brain's compensatory reaction to the failure of facial muscle movement [55]. The key point is why the overactivity was likewise demonstrated during the task of the acupuncture stimulus.…”

Section: Discussionmentioning

confidence: 99%

“…Considering that independent data is necessary for ANOVA and a t -test analysis, we simply compared different stages of the patients with healthy controls, but not between different stages of the patients, which might potentially influence the reliability of our results and should be clarified in future studies. Secondly, by the same strategy that some previous studies had used [44, 55], the data collected from patients with left-sided facial palsy were flipped across the midsagittal plane before group and intergroup analyses in the current study, and we added the factor of whether or not the data were flipped into the covariates when performing the group analysis. Nevertheless, it was still of bias when we took the factor of laterality into account.…”

Section: Discussionmentioning

confidence: 99%

“…Although some studies concluded that there is inadequate evidence to support the effectiveness of acupuncture for Bell's palsy [50, 51], a number of other studies have provided evidence that acupuncture is beneficial [2, 52, 53] or, as reported [54], that the efficacies of acupuncture, steroids, and natural course of recovery in Bell's palsy were the same with respect to the degree of recovery and speed of recovery. More importantly, Bell's palsy is a transient peripheral motor disease from which most of the patients would recover in several months and in which the brain anatomical structure was not significantly altered [55, 56]. The only changes in the brain that had been reported were the changes in the brain functional status or connectivity in the patients with Bell's palsy.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Brain Responses to Acupuncture Are Probably Dependent on the Brain Functional Status

Yang

Sun

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

In recent years, neuroimaging studies of acupuncture have explored extensive aspects of brain responses to acupuncture in finding its underlying mechanisms. Most of these studies have been performed on healthy adults. Only a few studies have been performed on patients with diseases. Brain responses to acupuncture in patients with the same disease at different pathological stages have not been explored, although it may be more important and helpful in uncovering its underlying mechanisms. In the present study, we used fMRI to compare brain responses to acupuncture in patients with Bell's palsy at different pathological stages with normal controls and found that the brain response to acupuncture varied at different pathological stages of Bell's palsy. The brain response to acupuncture decreased in the early stages, increased in the later stages, and nearly returned to normal in the recovered group. All of the changes in the brain response to acupuncture could be explained as resulting from the changes in the brain functional status. Therefore, we proposed that the brain response to acupuncture is dependent on the brain functional status, while further investigation is needed to provide more evidence in support of this proposition.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Brain Responses to Acupuncture Are Probably Dependent on the Brain Functional Status

Yang

Sun

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

Outcome‐dependent coactivation of lip and tongue primary somatosensory representation following hypoglossal–facial transfer after peripheral facial palsy

Rottler

Schroeder

Lotze

2012

Human Brain Mapping

View full text Add to dashboard Cite

A hypoglossal-facial transfer is a common surgical strategy for reanimating the face after persistent total hemifacial palsy. We were interested in how motor recovery is associated with cortical reorganization of lip and tongue representation in the primary sensorimotor cortex after the transfer. Therefore, we used functional magnetic resonance imaging (fMRI) in 13 patients who underwent a hypoglossal-facial transfer after unilateral peripheral facial palsy. To identify primary motor and somatosensory tongue and lip representation sites, we measured repetitive tongue and lip movements during fMRI. Electromyography (EMG) of the perioral muscles during tongue and lip movements and standardized evaluation of lip elevation served as outcome parameters. We found an association of cortical representation sites in the pre- and postcentral gyrus (decreased distance of lip and tongue representation) with symmetry of recovered lip movements (lip elevation) and coactivation of the lip during voluntary tongue movements (EMG-activity of the lip during tongue movements). Overall, our study shows that hypoglossal-facial transfer resulted in an outcome-dependent cortical reorganization with activation of the cortical tongue area for restituded movement of the lip.

show abstract

Cognition, body, and mind: A three‐in‐one coordinate‐based fMRI meta‐analysis on cognitive, physical, and meditative trainings

Presti

Origlia

Gianelli

et al. 2023

Human Brain Mapping

View full text Add to dashboard Cite

While mounting evidence shows promising effects of brain training on cognitive functioning in healthy and pathological conditions, the spread of variable training approaches highlights the need to compare their efficacy and identify their neural correlates, representing possible targets for neuromodulation treatments. We performed coordinate‐based functional magnetic resonance imaging meta‐analyses to compare the neural correlates and the cognitive outcomes of cognitive (n = 22), physical (n = 22), and meditative (n = 20) training in healthy non‐expert individuals. Pre/post‐training cognitive metrics improved after cognitive and physical training, but their heterogeneity, or even the lack of these measurements in some studies, highlights the need of more structured protocols. Cognitive, physical, and meditative interventions increased brain activity in distinct fronto‐medial areas likely mediating training effects on cognitive, action, and attentional control, respectively. The modular, training‐specific, engagement of a region that is known to mediate feedback‐based learning provides cues for boosting brain training via combined interventions that might jointly outperform their individual effects.

show abstract

Cortical reorganization in Bell's palsy

Cited by 34 publications

References 72 publications

Brain Responses to Acupuncture Are Probably Dependent on the Brain Functional Status

Brain Responses to Acupuncture Are Probably Dependent on the Brain Functional Status

Outcome‐dependent coactivation of lip and tongue primary somatosensory representation following hypoglossal–facial transfer after peripheral facial palsy

Cognition, body, and mind: A three‐in‐one coordinate‐based fMRI meta‐analysis on cognitive, physical, and meditative trainings

Contact Info

Product

Resources

About