Cortical quantitative MRI parameters are related to the cognitive status in patients with relapsing-remitting multiple sclerosis

Wijnen, Alexandra van; Petrov, Franca; Maiworm, Michelle; Frisch, Stefan; Foerch, Christian; Hattingen, Elke; Steinmetz, Helmuth; Klein, Johannes; Deichmann, Ralf; Wagner, Marlies; Gracien, René‐Maxime

doi:10.1007/s00330-019-06437-9

Cited by 12 publications

(15 citation statements)

References 41 publications

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“…Mean cortical T 2 values were determined across all non‐zero vertices for each subject, as discussed in a previous study, 30 and compared between groups with an unpaired t ‐test. The Pearson correlation coefficients between these values and clinical parameters (number of seizures in the previous 3 months and number of anticonvulsive drugs in the medical history, including current treatment) were calculated.…”

Section: Methodsmentioning

confidence: 99%

Cortical Changes in Epilepsy Patients With Focal Cortical Dysplasia: New Insights With T₂ Mapping

Ahmad

Maiworm

Nöth

et al. 2020

Magnetic Resonance Imaging

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Background: In epilepsy patients with focal cortical dysplasia (FCD) as the epileptogenic focus, global cortical signal changes are generally not visible on conventional MRI. However, epileptic seizures or antiepileptic medication might affect normal-appearing cerebral cortex and lead to subtle damage. Purpose: To investigate cortical properties outside FCD regions with T 2-relaxometry. Study Type: Prospective study. Subjects: Sixteen patients with epilepsy and FCD and 16 age-/sex-matched healthy controls. Field Strength/Sequence: 3T, fast spin-echo T 2-mapping, fluid-attenuated inversion recovery (FLAIR), and synthetic T 1weighted magnetization-prepared rapid acquisition of gradient-echoes (MP-RAGE) datasets derived from T 1-maps. Assessment: Reconstruction of the white matter and cortical surfaces based on MP-RAGE structural images was performed to extract cortical T 2 values, excluding lesion areas. Three independent raters confirmed that morphological cortical/juxtacortical changes in the conventional FLAIR datasets outside the FCD areas were definitely absent for all patients. Averaged global cortical T 2 values were compared between groups. Furthermore, group comparisons of regional cortical T 2 values were performed using a surface-based approach. Tests for correlations with clinical parameters were carried out. Statistical Tests: General linear model analysis, permutation simulations, paired and unpaired t-tests, and Pearson correlations. Results: Cortical T 2 values were increased outside FCD regions in patients (83.4 AE 2.1 msec, control group 81.4 AE 2.1 msec, P = 0.01). T 2 increases were widespread, affecting mainly frontal, but also parietal and temporal regions of both hemispheres. Significant correlations were not observed (P ≥ 0.55) between cortical T 2 values in the patient group and the number of seizures in the last 3 months or the number of anticonvulsive drugs in the medical history. Data Conclusion: Widespread increases in cortical T 2 in FCD-associated epilepsy patients were found, suggesting that structural epilepsy in patients with FCD is not only a symptom of a focal cerebral lesion, but also leads to global cortical damage not visible on conventional MRI. Evidence Level: 21 Technical efficacy Stage: 3

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Section: Methodsmentioning

confidence: 99%

Cortical Changes in Epilepsy Patients With Focal Cortical Dysplasia: New Insights With T₂ Mapping

Ahmad

Maiworm

Nöth

et al. 2020

Magnetic Resonance Imaging

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“…In comparison, some earlier studies reported increased T1 values in the cortex ( 12 , 13 , 38 ). While others did not find significant differences in T1-RT in the cortex and thalami between patients with MS and healthy controls ( 14 , 26 ).…”

Section: Discussionmentioning

confidence: 86%

T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis

et al. 2021

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Background: Cortical and thalamic pathologies have been associated with cognitive impairment in patients with multiple sclerosis (MS).Objective: We aimed to quantify cortical and thalamic damage in patients with MS using a high-resolution T1 mapping technique and to evaluate the association of these changes with clinical and cognitive impairment.Methods: The study group consisted of 49 patients with mainly relapsing-remitting MS and 17 age-matched healthy controls who received 3T MRIs including a T1 mapping sequence (MP2RAGE). Mean T1 relaxation times (T1-RT) in the cortex and thalami were compared between patients with MS and healthy controls. Additionally, correlation analysis was performed to assess the relationship between MRI parameters and clinical and cognitive disability.Results: Patients with MS had significantly decreased normalized brain, gray matter, and white matter volumes, as well as increased T1-RT in the normal-appearing white matter, compared to healthy controls (p < 0.001). Partial correlation analysis with age, sex, and disease duration as covariates revealed correlations for T1-RT in the cortex (r = −0.33, p < 0.05), and thalami (right thalamus: r = −0.37, left thalamus: r = −0.50, both p < 0.05) with working memory and information processing speed, as measured by the Symbol-Digit Modalities Test.Conclusion: T1-RT in the cortex and thalamus correlate with information processing speed in patients with MS.

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“…More importantly, the basic data of patients' cognitive function should be kept to determine whether it has changed in the future. Early assessment is important because MCI is not a normal aging process and has a high risk of progression to dementia (26,27).…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta-analysis of diagnostic test accuracy (DTA) studies: the role of cerebral perfusion imaging in prognosis evaluation of mild cognitive impairment

Zhu¹,

Zhao²,

Li³

et al. 2022

Ann Palliat Med

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Background: The application value of cerebral perfusion imaging, such as fluorodeoxyglucose-positronemission computed tomography (FDG-PET), single-photon emission computed tomography (SPECT), and structural magnetic resonance imaging (MRI), in the prognostic assessment of mild cognitive impairment (MCI) remains unclear. Thus, it was the focus of this meta-analysis, which aimed to provide a theoretical basis for early diagnosis of neurological diseases.Methods: The Boolean logic retrieval method was used to retrieve related literature, with "cognitive disorder", "cerebral perfusion imaging", "cerebral imaging", "mild cognitive impairment", and "prognostic assessment" as search terms. The PubMed, Medline, CNKI (China National Knowledge Infrastructure), and other databases were searched from the date of establishment of the database to December 30, 2020 for literature on the prognostic assessment of MCI using FDG-PET, SPECT, and MRI imaging. Meta-analysis was performed using Review Manager software.Results: A total of 16 references were identified, most of which had a low risk of bias (i.e. medium and high-quality). The meta-analysis results showed that the sensitivity and specificity of FDG-PET imaging was significantly higher than those of SPECT and MRI imaging, and the differences were statistically significant (P<0.05). The summary receiver operating characteristic (sROC) curves for the sensitivity and specificity of FDG-PET, SPECT, and MRI imaging did not present a "shoulder arm" distribution, and there was no threshold effect. Discussion: Cerebral perfusion imaging has good prognostic value for patients with MCI, and FDG-PET imaging has better predictive ability of the prognosis for patients with MCI.

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Cortical quantitative MRI parameters are related to the cognitive status in patients with relapsing-remitting multiple sclerosis

Cited by 12 publications

References 41 publications

Cortical Changes in Epilepsy Patients With Focal Cortical Dysplasia: New Insights With T₂ Mapping

Cortical Changes in Epilepsy Patients With Focal Cortical Dysplasia: New Insights With T₂ Mapping

T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis

Systematic review and meta-analysis of diagnostic test accuracy (DTA) studies: the role of cerebral perfusion imaging in prognosis evaluation of mild cognitive impairment

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Cortical quantitative MRI parameters are related to the cognitive status in patients with relapsing-remitting multiple sclerosis

Cited by 12 publications

References 41 publications

Cortical Changes in Epilepsy Patients With Focal Cortical Dysplasia: New Insights With T2 Mapping

Cortical Changes in Epilepsy Patients With Focal Cortical Dysplasia: New Insights With T2 Mapping

T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis

Systematic review and meta-analysis of diagnostic test accuracy (DTA) studies: the role of cerebral perfusion imaging in prognosis evaluation of mild cognitive impairment

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Cortical Changes in Epilepsy Patients With Focal Cortical Dysplasia: New Insights With T₂ Mapping

Cortical Changes in Epilepsy Patients With Focal Cortical Dysplasia: New Insights With T₂ Mapping