Cortical projections to the periaqueductal gray in the monkey: A retrograde and orthograde horseradish peroxidase study

Hardy, Sandro; Leichnetz, George R.

doi:10.1016/0304-3940(81)90070-7

Cited by 89 publications

(30 citation statements)

References 5 publications

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“…2). The cACC projects directly to the PAG (Hardy and Leichnetz, 1981) and, in primates, neurons in this area respond to both noxious stimuli and to cues predictive of noxious stimuli (Koyama et al, 1998). Pain expectancy has also been reported to produce enhancement of cACC activity and reports of pain in the presence of an innocuous warm stimulus (Sawamoto et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Isolating the Modulatory Effect of Expectation on Pain Transmission: A Functional Magnetic Resonance Imaging Study

Keltner

Furst²,

Fan³

et al. 2006

J. Neurosci.

315

223

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We use a novel balanced experimental design to specifically investigate brain mechanisms underlying the modulating effect of expected pain intensity on afferent nociceptive processing and pain perception. We used two visual cues, each conditioned to one of two noxious thermal stimuli [ϳ48°C (high) or 47°C (low)]. The visual cues were presented just before and during application of the noxious thermal stimulus. Subjects reported significantly higher pain when the noxious stimulus was preceded by the high-intensity visual cue. To control for expectancy effects, for one-half of the runs, the noxious thermal stimuli were accompanied by the cue conditioned to the other stimulus. Comparing functional magnetic resonance imaging blood oxygenation level-dependent activations produced by the high and low thermal stimulus intensities presented with the high-intensity visual cue showed significant activations in nociceptive regions of the thalamus, second somatosensory cortex, and insular cortex. To isolate the effect of expectancy, we compared activations produced by the two visual cues presented with the high-intensity noxious thermal stimulus; this showed significant differences in the ipsilateral caudal anterior cingulate cortex, the head of the caudate, cerebellum, and the contralateral nucleus cuneiformis (nCF). We propose that pain intensity expectancy modulates activations produced by noxious stimuli through a distinct modulatory network that converges with afferent nociceptive input in the nCF.

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Section: Discussionmentioning

confidence: 99%

Isolating the Modulatory Effect of Expectation on Pain Transmission: A Functional Magnetic Resonance Imaging Study

Keltner

Furst²,

Fan³

et al. 2006

J. Neurosci.

315

223

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“…Activation of these areas is correlated with decreased pain ratings during attention demanding tasks (Bantick et al, 2002;Valet et al, 2004). Across different species, numerous prefrontal areas (Hardy and Leichnetz, 1981;Floyd et al, 2000) and ACC (Floyd et al, 2000) have been found to project to the periaqueductal gray (PAG). In humans, the PAG is activated during cognitive and attentional tasks and, together with other brainstem regions (Heinricher et al, 1997), is able to modulate nociceptive processing .…”

Section: Cortical/subcortical Activity and Attentionmentioning

confidence: 99%

Attentional Modulation of Spatial Integration of Pain: Evidence for Dynamic Spatial Tuning

Quevedo

Coghill²

2007

J. Neurosci.

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In many sensory modalities, afferent processing is dynamically modulated by attention and this modulation produces altered sensory experiences. Attention is able to alter perceived pain, but the mechanisms involved in this modulation have not been elucidated. To determine whether attention alters spatial integration of nociceptive information, subjects were recruited to evaluate pain from pairs of noxious/innocuous thermal stimuli during different spatial attentional tasks. Divided attention was able to abolish spatial summation and produce inhibition of pain. In contrast, directed attention enhanced pain intensity by partially integrating both stimuli. This dynamic modulation of spatial integration indicates that attention alters spatial dimensions of afferent nociceptive processing to optimize the perceptual response to input from a particular body region or stimulus feature. This dynamic spatial tuning of nociceptive processing provides a new conceptual insight into the functional significance of endogenous pain inhibitory and facilitatory mechanisms.

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“…Das System funktioniert durch die schnelle, automatische Gegenregulation zur Kontrolle nozizeptiver afferenter Information via absteigender inhibitorischer Bahnen. Das PAG erhält u. a. Signale vom Frontalkortex [40], Hypothalamus [6], dem anterioren Insulakortex [21] und den Amygdalae [20], die alle auch mit der Schmerzverarbeitung assoziiert wurden. Das kaudale PAG leitet die Informationen weiter zur RVM, die diese ihrerseits zu den schmerzübertragenden Neuronen des Hinterhorns und der Trigeminusganglien weiterleitet.…”

Section: Zentrale Schmerzverarbeitungunclassified

Zentrale Schmerzverarbeitung bei chronischem Rückenschmerz

Giesecke

Gracely

Clauw

et al. 2006

Schmerz

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Cortical projections to the periaqueductal gray in the monkey: A retrograde and orthograde horseradish peroxidase study

Cited by 89 publications

References 5 publications

Isolating the Modulatory Effect of Expectation on Pain Transmission: A Functional Magnetic Resonance Imaging Study

Isolating the Modulatory Effect of Expectation on Pain Transmission: A Functional Magnetic Resonance Imaging Study

Attentional Modulation of Spatial Integration of Pain: Evidence for Dynamic Spatial Tuning

Zentrale Schmerzverarbeitung bei chronischem Rückenschmerz

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