Cortical processing of speech in individuals with auditory neuropathy spectrum disorder

Apeksha, Kumari; Uppunda, Ajith Kumar

doi:10.1007/s00405-018-4966-8

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…Apeksha and Kumar (12) also observed that the brain networks and areas activated in patients with ANSD during detection and discrimination of speech stimuli were not similar to individuals with normal hearing. In other words, normal-hearing individuals showed shorter reaction times and more focused activation compared to those with ANSD.…”

Section: Discussionmentioning

confidence: 99%

“…The ANSD may be associated with an inner hair cell lesion, ribbon synapse dysfunction, or cochlear nerve impairment (e.g., demyelination or axonal degeneration). The auditory deprivation due to peripheral sensory impairment can lead to alternations in the cortical structures and functions, such as thinning of the cortex, grey matter volume, and white matter integrity (12)(13)(14). It is known that the process of cortical maturation does not only depend on the amount of sensory stimulation but also is largely dependent on the pattern of neural activity received from the peripheral systems.…”

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confidence: 99%

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Cortical Auditory Plasticity Following Cochlear Implantation in Children With Auditory Neuropathy Spectrum Disorder: A Prospective Study

Saki

Nikakhlagh

Moridi

et al. 2021

Otology &Amp; Neurotology

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Objectives: The cortical auditory evoked potential (CAEP) can provide an insight into the maturation of the central auditory nervous system by recording the auditory cortex responses to speech stimuli. This study aimed to explore the central auditory system development in children with auditory neuropathy spectrum disorder (ANSD) using cochlear implants (CIs) and to find the correlation of CAEP biomarkers with speech perception. Methods: This study was performed on 23 children with prelingual deafness, diagnosed with ANSD, as well as 23 children with prelingual deafness, without ANSD as the control group. All children underwent unilateral CI before the age of 3 years. Children with ANSD were classified into two groups, based on their CAEP results prior to implantation: children with a clear CAEP response (ANSD-I) and children without an identifiable CAEP (ANSD-II). The P1 component of CAEPs and speech intelligibility rating (SIR) were recorded before the initial device activation (baseline) and at 6, 12, and 24 months postimplantation. Results:The P1 CAEP responses were present in all children in the control group, while they were recorded in only 52% of ANSD children before the CI surgery. The longitudinal analysis revealed a significant reduction in the P1 latency and a significant improvement in the P1 amplitude across different time points in all study groups. However, the P1 latency and P1 amplitude were significantly shorter and larger in the control group than the ANSD group, respectively. Also, children in the ANSD-I group exhibited a slightly shorter P1 latency, a larger P1 amplitude, and a higher SIR score than the ANSD-II group after 2 years of follow-up. The P1 CAEP latency was significantly correlated with the SIR score. Conclusion:The CAEP can be used as an objective indicator of auditory cortical maturation and a predictor of speech perception performance in implanted children with ANSD.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Cortical Auditory Plasticity Following Cochlear Implantation in Children With Auditory Neuropathy Spectrum Disorder: A Prospective Study

Saki

Nikakhlagh

Moridi

et al. 2021

Otology &Amp; Neurotology

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“…In the majority of the studies, researchers have recorded P1-N1-P2 potentials 14,15,36,49,50, mismatch negativity 16,17 and P300 34,37,38 in quiet condition for individuals with ANSD. The result of the previous study investigating P300 response in individuals with ANSD 34,37 showed prolongation in latency of P300 response, reduction in amplitude of P300 response, prolonged RT and poorer sensitivity in quiet condition for different stimuli in individuals with ANSD compared with individuals with normal hearing sensitivity. Similar findings were observed in the present study, suggesting that the individuals with ANSD might have difficulty in stimulus evaluation and in the speech discrimination process.…”

Section: Discussionmentioning

confidence: 99%

“…[14][15][16][34][35][36] To our knowledge, there are only two studies reported in the literature that discuss the multichannel recording in individuals with ANSD. 37,38 Apeksha et al 37 recorded P300 response in individuals with ANSD for speech contrast /ba/-/da/, whereas Apeksha et al 38 recorded P300 response in individuals with ANSD for the three different speech contrasts /ba/-/da/, /ba/-/ma/ and /ba/-/pa/. In both studies, the P300 response was recorded only in quiet listening condition.…”

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confidence: 99%

Effect of Quiet and Noise on P300 Response in Individuals with Auditory Neuropathy Spectrum Disorder

Apeksha

Kumar

2020

Int Arch Otorhinolaryngol

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Introduction Auditory neuropathy spectrum disorder (ANSD) is a clinical condition in which individuals have normal cochlear responses and abnormal neural responses. There is a lack of evidence in the literature regarding the neural discrimination skill in individuals with ANSD, especially when the signal is presented in the presence of noise. Objectives The present study was performed with the aim to investigate auditory discrimination skill, in quiet and in the presence of noise, in individuals with ANSD and to compare the findings with normal-hearing individuals. Methods A total of 30 individuals with normal hearing sensitivity and 30 individuals with ANSD in the age range of 15 to 55 years old, with the mean age of 27.86 years old, were the participants. P300 response was recorded from both groups using syllable pairs /ba/-/da/ in oddball paradigm and the syllable /da/ in repetitive paradigm in quiet and at +10 dB signal-to-noise ratio (SNR). Results There was significant prolongation in latency and reaction time, and reduction in amplitude of P300 response and sensitivity in both groups with the addition of noise. The topographic pattern analysis showed activation of the central-parietal-occipital region of the brain in individuals with ANSD, whereas activation of the central-parietal region was observed in individuals with normal hearing. The activation was more diffused in individuals with ANSD compared with that of individuals with normal hearing. Conclusion The individuals with ANSD showed a significantly more adverse effect of noise on the neural discrimination skill than the normal counterpart.

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Leitlinie „Auditive Verarbeitungs- und Wahrnehmungsstörungen“: Definition

Ptok

Kiese-Himmel

Nickisch

2018

HNO

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Cortical processing of speech in individuals with auditory neuropathy spectrum disorder

Cited by 5 publications

References 33 publications

Cortical Auditory Plasticity Following Cochlear Implantation in Children With Auditory Neuropathy Spectrum Disorder: A Prospective Study

Cortical Auditory Plasticity Following Cochlear Implantation in Children With Auditory Neuropathy Spectrum Disorder: A Prospective Study

Effect of Quiet and Noise on P300 Response in Individuals with Auditory Neuropathy Spectrum Disorder

Leitlinie „Auditive Verarbeitungs- und Wahrnehmungsstörungen“: Definition

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