Cortical processing in vestibular navigation

Seemungal, Barry M.; Rizzo, Maria Rosaria; Ma, Gresty; Rothwell, John C.; Am, Bronstein

doi:10.1016/s0079-6123(08)00650-x

Cited by 11 publications

(9 citation statements)

References 27 publications

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“…Therefore, the impairment of the ISP to memorize and process vestibular inputs could be due to an alteration of the cortical network processing vestibular signals. This would be consistent with the findings that, repetitive transcranial magnetic stimulation applied to the right posterior parietal cortex of healthy participants, impairs encoding of vestibular-derived displacement perception [ 25 ].…”

Section: Discussionsupporting

confidence: 92%

Evidence for cognitive vestibular integration impairment in idiopathic scoliosis patients

et al. 2009

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Background: Adolescent idiopathic scoliosis is characterized by a three-dimensional deviation of the vertebral column and its etiopathogenesis is unknown. Various factors cause idiopathic scoliosis, and among these a prominent role has been attributed to the vestibular system. While the deficits in sensorimotor transformations have been documented in idiopathic scoliosis patients, little attention has been devoted to their capacity to integrate vestibular information for cognitive processing for space perception. Seated idiopathic scoliosis patients and control subjects experienced rotations of different directions and amplitudes in the dark and produced saccades that would reproduce their perceived spatial characteristics of the rotations (vestibular condition). We also controlled for possible alteration of the oculomotor and vestibular systems by measuring the subject's accuracy in producing saccades towards memorized peripheral targets in absence of body rotation and the gain of their vestibulo-ocular reflex.

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Section: Discussionsupporting

confidence: 92%

Evidence for cognitive vestibular integration impairment in idiopathic scoliosis patients

et al. 2009

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“…1: pointing responses with the eyes or the whole-body itself (Metcalfe and Gresty 1992, Kanayama et al 1995, or with various devices indicating body orientation or velocity like button, tachometer, joystick (Okada et al 1999, Seemungal et al 2004, Kyriakareli et al 2013and Tremblay et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of vestibular disorders on vestibular reflex and imagery

et al. 2017

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The aim of this study was to establish the effect of vestibular lesion on vestibular imagery. Subjects were required to estimate verbally their passively travelled rotation angles in complete darkness, i.e., to activate vestibular imagery. During motion, the vestibulo-ocular reflex (VOR) was measured. Thus, we examined the coherence between the vestibulo-ocular reflex and self-rotation imagery, with vestibular-lesioned patients and healthy participants. Unilateral acute and chronic patients, bilateral patients, and healthy subjects were compared. The stimulus was a sequence of eight successive passive rotations, with four amplitudes (from 90° to 360°) in two directions. The VOR gain was lower in patients with unilateral lesions, for ipsilateral rotations. The healthy subjects had the highest gain and the bilateral group the lowest, on both rotation sides. Thanks to vestibular compensation after acute unilateral neuritis, the VOR gain increased in lesion side and decreased in healthy side, resulting in a similar gain in both sides. A deficit of vestibular imagery was found exclusively in patients with bilateral hyporeflexia, on both sides. The performance in vestibular imagery was good in the control group and correct in the unilateral patients. Finally, we found a significant correlation between the efficiency of the VOR and that of vestibular imagery, exclusively in the bilateral patients. The present study shows the complex relationship between vestibular imagery and the VOR. This imagery test contributes to another assessment of the spatial handicap of vestibular patients. It seems particularly interesting for patients with bilateral canal paresis and could be used to confirm this diagnosis.

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“…When TMS was applied to posterior parietal cortex during the encoding phase of a rotation it resulted in increased errors when estimating angular displacements, but it did not affect velocity perception. This revealed that posterior parietal cortex may play a critical role in path integration -the process by which angular position in space is determined [15,17,18]. The above studies illustrate how TMS can be used to focally probe and dissociate the specific contribution of different brain regions involved in vestibular cortical processing.…”

Section: Transcranial Magnetic Stimulationmentioning

confidence: 83%

Applications of neuromodulation to explore vestibular cortical processing; new insights into the effects of direct current cortical modulation upon pursuit, VOR and VOR suppression

Ahmad

Arshad

Siddiqui

et al. 2014

VES

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Functional imaging, lesion studies and behavioural observations suggest that vestibular processing is lateralised to the non-dominant hemisphere. Moreover, disruption of interhemispheric balance via inhibition of left parietal cortex using transcranial direct current stimulation (tDCS) has been associated with an asymmetric suppression of the vestibulo-ocular reflex (VOR). However, the mechanism by which the VOR was modulated remains unknown. In this paper we review the literature on noninvasive brain stimulation techniques which have been used to probe vestibular function over the last decade. In addition, we investigate the mechanisms whereby tDCS may modulate VOR, e.g. by acting upon pursuit, VOR suppression mechanisms or direct VOR modulation. We applied bi-hemispheric parietal tDCS in 11 healthy subjects and only observed significant effects on VOR gain (tdcs * condition p = 0.041) -namely a trend for VOR gain increase with right anodal/left cathodal stimulation, and a decrease with right cathodal/left anodal stimulation. Hence, we suggest that the modulation of the VOR observed both here and in previous reports, is directly caused by top-down cortical control of the VOR as a result of disruption to interhemispheric balance, likely parietal.

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Cortical processing in vestibular navigation

Cited by 11 publications

References 27 publications

Evidence for cognitive vestibular integration impairment in idiopathic scoliosis patients

Evidence for cognitive vestibular integration impairment in idiopathic scoliosis patients

Effects of vestibular disorders on vestibular reflex and imagery

Applications of neuromodulation to explore vestibular cortical processing; new insights into the effects of direct current cortical modulation upon pursuit, VOR and VOR suppression

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