Cortical muscle coupling in Parkinson’s disease (PD) bradykinesia

McKeown, Martin J.; Palmer, Samantha; Au, Wing Lok; McCaig, R.G.; Saab, Rayan; Abugharbieh, Rafeef

doi:10.1007/978-3-211-45295-0_7

Cited by 15 publications

(12 citation statements)

References 50 publications

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“…Beta-band intermuscular or corticomuscular coherence also seems to require functioning basal ganglia circuitry (Grosse et al ., 2002) because in Parkinson’s disease it is diminished when treatment is withdrawn and restored to levels comparable to those seen in healthy age-matched control subjects by stimulation of the subthalamic nucleus or administration of l -DOPA (McAuley et al ., 2001; McKeown et al ., 2006). Although Parkinson’s disease and motor neuron disease occur together very infrequently (Williams et al ., 1995), caution should be exercised when interpreting results if parkinsonian features are present.…”

Section: Discussionmentioning

confidence: 99%

Beta-band intermuscular coherence: a novel biomarker of upper motor neuron dysfunction in motor neuron disease

Fisher

Zaaimi

Williams

et al. 2012

Brain

120

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In motor neuron disease, the focus of therapy is to prevent or slow neuronal degeneration with neuroprotective pharmacological agents; early diagnosis and treatment are thus essential. Incorporation of needle electromyographic evidence of lower motor neuron degeneration into diagnostic criteria has undoubtedly advanced diagnosis, but even earlier diagnosis might be possible by including tests of subclinical upper motor neuron disease. We hypothesized that beta-band (15–30 Hz) intermuscular coherence could be used as an electrophysiological marker of upper motor neuron integrity in such patients. We measured intermuscular coherence in eight patients who conformed to established diagnostic criteria for primary lateral sclerosis and six patients with progressive muscular atrophy, together with 16 age-matched controls. In the primary lateral sclerosis variant of motor neuron disease, there is selective destruction of motor cortical layer V pyramidal neurons and degeneration of the corticospinal tract, without involvement of anterior horn cells. In progressive muscular atrophy, there is selective degeneration of anterior horn cells but a normal corticospinal tract. All patients with primary lateral sclerosis had abnormal motor-evoked potentials as assessed using transcranial magnetic stimulation, whereas these were similar to controls in progressive muscular atrophy. Upper and lower limb intermuscular coherence was measured during a precision grip and an ankle dorsiflexion task, respectively. Significant beta-band coherence was observed in all control subjects and all patients with progressive muscular atrophy tested, but not in the patients with primary lateral sclerosis. We conclude that intermuscular coherence in the 15–30 Hz range is dependent on an intact corticospinal tract but persists in the face of selective anterior horn cell destruction. Based on the distributions of coherence values measured from patients with primary lateral sclerosis and control subjects, we estimated the likelihood that a given measurement reflects corticospinal tract degeneration. Therefore, intermuscular coherence has potential as a quantitative test of subclinical upper motor neuron involvement in motor neuron disease.

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Section: Discussionmentioning

confidence: 99%

Beta-band intermuscular coherence: a novel biomarker of upper motor neuron dysfunction in motor neuron disease

Fisher

Zaaimi

Williams

et al. 2012

Brain

120

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“…In Parkinson's disease, pathological beta oscillations in the basal ganglia (reviewed previously (Little and Brown, 2014)) are an established therapeutic target for deep-brain stimulation. While CMC appears preserved early in the Parkinson's disease course (Pollok et al, 2012), subsequent symptomatic relief with either L-Dopa (Mckeown et al, 2006;Salenius et al, 2002) or DBS (Airaksinen et al, 2015) is accompanied by CMC modulation. A previous coherence study investigated the impact of two extremes of the ALS clinical spectrum, namely the 'pure' UMN disorder primary lateral sclerosis (PLS) and the lower motor neuron (LMN) condition termed progressive muscular atrophy (PMA), on the functional integrity of cortical drive to the first dorsal interosseous muscle (Fisher et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis

Proudfoot

Ede

Quinn

et al. 2018

Clinical Neurophysiology

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“…Moreover, corticomuscular motor integration in PD is dominated by low‐frequent drives from cortex to muscle mainly below 10 Hz (Salenius et al. , 2002; McKeown et al. , 2006), whereas in healthy subjects isometric contraction of weak to moderate strength is characterized by corticomuscular synchronization in the beta frequency band (Conway et al.…”

Section: Introductionmentioning

confidence: 99%

Subthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement

Weiß

Breit

Hoppe

et al. 2012

Eur J of Neuroscience

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Pathological synchronization in large-scale motor networks constitutes a pathophysiological hallmark of Parkinson's disease (PD). Corticomuscular synchronization in PD is pronounced in lower frequency bands (< 10 Hz), whereas efficient cortical motor integration in healthy persons is driven in the beta frequency range. Electroencephalogram and electromyogram recordings at rest and during an isometric precision grip task were performed in four perioperative sessions in 10 patients with PD undergoing subthalamic nucleus deep-brain stimulation: (i) 1 day before (D0); (ii) 1 day after (D1); (iii) 8 days after implantation of macroelectrodes with stimulation off (D8StimOff); and (iv) on (D8StimOn). Analyses of coherence and phase delays were performed in order to challenge the effects of microlesion and stimulation on corticomuscular coherence (CMC). Additionally, local field potentials recorded from the subthalamic nucleus on D1 allowed comprehensive mapping of motor-related synchronization in subthalamocortical and cerebromuscular networks. Motor performance improved at D8StimOn compared with D0 and D8StimOff paralleled by a reduction of muscular activity and CMC in the theta band (3.9-7.8 Hz) and by an increase of CMC in the low-beta band (13.7-19.5 Hz). Efferent motor cortical drives to muscle presented mainly below 10 Hz on D8StimOff that were suppressed on D8StimOn and occurred on higher frequencies from 13 to 45 Hz. On D1, coherence of the high-beta band (20.5-30.2 Hz) increased during movement compared with rest in subthalamomuscular and corticomuscular projections, whereas it was attenuated in subcorticocortical projections. The present findings lend further support to the concept of pathological network synchronization in PD that is beneficially modulated by stimulation.

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Cortical muscle coupling in Parkinson’s disease (PD) bradykinesia

Cited by 15 publications

References 50 publications

Beta-band intermuscular coherence: a novel biomarker of upper motor neuron dysfunction in motor neuron disease

Beta-band intermuscular coherence: a novel biomarker of upper motor neuron dysfunction in motor neuron disease

Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis

Subthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement

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