Cortical multineuronal activity in dogs with defensive instrumental conditioned reflex

Dolbakyan, É. E.; Merzhanova, G. Kh.; Tveritskaya, I. N.

doi:10.1007/bf01192345

Cited by 1 publication

(5 citation statements)

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“…All instances of significant peaks, both in the ACG and on the CIHG, in complete conformity with the results of the previous investigation [8], looked like fairly narrow outliers, which were encountered throughout the entire analysis epoch, up to 2000 msec. The width of a peak at its apex as a rule did not exceed one bin, from 0.5-1 msec up to 40 msec.…”

Section: Investigation Resultssupporting

confidence: 73%

“…And only recently did a report appear [24] regarding the recording of unilateral peaks of the cross-interval relationship in awake monkeys in the auditory and frontal regions of the cortex with a width from two to several msec, and with various time lags, right up to several hundreds of msec. The authors call these peaks, which are completely analogous to those recorded by us previously [8] and those recorded in the present study, "narrow" and "ultranarrow'. In their opinion, which it is hard not to agree with, the notions [15] of the so-called synchronous activation along a chain (synfire chain) may be a theoretical explanation of such manifestations of the cross-interval association.…”

Section: Discussion Of Resultssupporting

confidence: 65%

“…We had previously demonstrated [8], as referred to above, that cross-interval interrelationships of the background impulse series of neurons which were discriminated from the MNA were practically entirely represented in the sensorimotor cortex of awake dogs by unilateral single peaks, recorded approximately in one third of the pairs of impulse series. The cross-interval associations were comprised of fairly narrow, most often single-bin outliers which were encountered across the entire analysis epoch up to 500 msec (given fixed bin width values of 0.5, 2, and 10 msec).…”

Section: Discussion Of Resultsmentioning

confidence: 96%

“…The experiments were carried out in two mongrel dogs, weighing 15 and 18 kg, respectively, which were previously trained to a conditioned avoidance reflex using the methods of V. P. Petropavlovskii [8].…”

Section: Methodsmentioning

confidence: 99%

“…This is precisely the path which we chose to study the functional organization of microsegments of the sensorimotor region of the cerebral cortex in dogs [8].…”

Section: The Interneuronal Functional Associations Were Studied In Twmentioning

confidence: 99%

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Interneuronal functional associations in the sensorimotor cortex of dogs

Dolbakyan

Tarakanova²,

Fadeeva³

1995

Neurosci Behav Physiol

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The interneuronal functional associations were studied in two dogs with Nichrome semi-microelectrodes implanted into the deep layers of the motor and somatosensory regions of the cerebral cortex using the method of cross-correlation analysis. For this purpose the impulse activity of individual neurons was distinguished byThe recording of multineuronal activity (MNA) through chronically implanted semi-microelectrodes may be considered one of the most appropriate techniques for the study of the physiological mechanisms of the interneuronal interactions [6]. An increasing number of neurophysiologists are in firm agreement with the notion [7] that the MNA is the impulse activity of neurons which vary in size and consequently are functionally heterogeneous, and which constitute a spatially separate microgroup. Data regarding the nested, columnar organization of the central nervous system serve as the morphological basis for this hypothesis [1,3,4,20].The recording of MNA in combination with cross-correlation analysis, aptly named "electronic horseradish peroxidase" [22], makes it possible to penetrate the structure of actually existing local cortical networks. This is precisely the path which we chose to study the functional organization of microsegments of the sensorimotor region of the cerebral cortex in dogs [8].The impulse series of three neurons were distinguished for these purposes from the background MNA through the use of amplitude discrimination, and their functional associations were studied by means of cross-interval histograms (CIHG), using three fixed bin width values, 0.5, 2, and 10 msec.In awake dogs, both untrained and trained, the cross-interval interrelationships were manifested in the form of single, unilateral peaks, which in terms of form most likely attest to direct excitatory associations between neighboring neurons [11, 211.The complete absence of broad central peaks, which are an indicator of a common excitatory source [21], was surprising, although under anesthesia they were recorded as the basic type of cross-interval association beneath the very same electrodes.Visible indicators of inhibitory interactions, both direct and from a common source, were also absent; this is only partially explained by the lower sensitivity of cross-correlation analysis for the discrimination of inhibitory associations [16].If the cross-interval associations we recorded with short delays up to 10 msec, and delays of medium duration, several tens of msec, could be explained on the basis of theoretical perspectives and facts [21] as manifestations of the direct effects Institute of Higher

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Section: Investigation Resultssupporting

confidence: 73%

Section: Discussion Of Resultssupporting

confidence: 65%

Section: Discussion Of Resultsmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

“…This is precisely the path which we chose to study the functional organization of microsegments of the sensorimotor region of the cerebral cortex in dogs [8].…”

Section: The Interneuronal Functional Associations Were Studied In Twmentioning

confidence: 99%

See 3 more Smart Citations