Cortical Mechanisms Involved in the Processing of Verbs: An fMRI Study

Yokoyama, Satoru; Miyamoto, Tadao; Riera, Jorge J.; Kim, Jungho; Akitsuki, Yuko; Iwata, Kazunori; Yoshimoto, Kei; Horie, Kazuyuki; Sato, Shigeru; Kawashima, Ryuta

doi:10.1162/jocn.2006.18.8.1304

Cited by 71 publications

(58 citation statements)

References 31 publications

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“…Furthermore, differential activations of frontal/prefrontal regions for verbs, and middle/posterior temporal regions for nouns, have been reported in neuroimaging studies with neurotypical native speakers of English [39,40], German [41], Italian [42], and Japanese [43]. 1 Note, however, that the latter findings refer to motor action verbs in general, and only to verbs.…”

Section: Action-language Impairments In Parkinson's Diseasementioning

confidence: 94%

Words in motion: Motor-language coupling in Parkinson’s disease

García¹,

Ibáñez²

2014

Translational Neuroscience

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In recent years, the disruption of non-motor functions in motor disease has emerged as a promising topic for both basic and translational neuroscience. Impairments of movement and cognition were long regarded as separate phenomena [1]. However, a growing body of evidence indicates that neurodegenerative motor disorders also involve high-order cognitive dysfunctions, ranging from working memory, attention, and executive processing deficits [2][3][4], to impairments of language [4][5][6][7][8][9][10] and action knowledge [11]. Further data comes from studies showing that the same genes (e.g., C9orf72) are involved in diseases once perceived as purely motor or purely cognitive, such as motor neuron disease (MND) and frontotemporal dementia, respectively [12].A cognitive domain which seems to be specifically compromised in motor diseases is action language, that is, processing of linguistic stimuli denoting motor actions, including idioms (e.g., cut a rug) and action verbs Words in moTion: moTor-lAnguAge couPling in PArkinson's diseAse Abstract A growing body of evidence indicates that neurodegenerative motor disorders involved high-order cognitive dysfunctions. Crucially, evidence obtained in multiple behavioral, neuroimaging, and electrophysiological studies points to selective impairments of action language -that is, processing of linguistic stimuli denoting motor actions, including idioms (e.g., cut a rug) and action verbs (e.g., clap). Action-verb deficits (with relative preservation of noun processing) have been repeatedly documented in Parkinson's disease (PD). However, research on relevant biomarkers is still scant, and clinical implications of these findings have not yet been formally discussed. Relevant insights may be obtained through the assessment of motor-language coupling (i.e., the behavioral and neural integration of action-verb processing and ongoing motor actions). We propose that motorlanguage coupling deficits, as indexed by a cortical-subcortical network, may constitute an early neurocognitive marker of PD. Specifically, deficits in this domain at the prodromal stage may be detected through the actionsentence compatibility (ACE) paradigm, which induces a contextual coupling of ongoing motor actions and action-verb processing. Our translational proposal is supported and illustrated by recent studies demonstrating the sensitivity of the ACE technique as well as its potential to assist in differential diagnosis and interventionprogram design.

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Section: Action-language Impairments In Parkinson's Diseasementioning

confidence: 94%

Words in motion: Motor-language coupling in Parkinson’s disease

García¹,

Ibáñez²

2014

Translational Neuroscience

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“…Moreover, the direct contrast of verb minus noun generation revealed activation of the left inferior temporal gyrus (as well as the left inferior parietal lobe, LIFG, and SMA). Warburton et al suggested that the inferior temporal gyrus and the posterior part of the inferior parietal lobe are important in lexical processing and in particular in the access to semantic fields (for further evidence showing that activation of the left middle temporal gyrus is increased for verbs relative to nouns, see also Yokoyama et al, 2006).…”

Section: Left Temporal Lobementioning

confidence: 99%

Item Retrieval and Competition in Noun and Verb Generation: An fMRI Study

Crescentini

Shallice

Macaluso

2010

Journal of Cognitive Neuroscience

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Abstract■ Selection between competing responses and stimulus-response association strength is thought to affect performance during verb generation. However, the specific contribution of these two processes remains unclear. Here we used fMRI to investigate the role of selection and association within frontal and BG circuits that are known to be involved in verb production. Subjects were asked to generate verbs from nouns in conditions requiring either high or low selection, but with constant association strength, and in conditions of weak or strong association strength, now with constant selection demands. Furthermore, we examined the role of selection and association during noun generation from noun stimuli. We found that the midpart of the left inferior frontal gyrus was more active in conditions requiring high compared with low selection, with matched association strength. The same left inferior frontal region activated irrespective of verb or noun generation. Results of ROI analyses showed effects of association strength only for verb generation and specifically in the anterior/ventral part of the left inferior frontal gyrus. Moreover, the BG were more active when weakly associated verbs had to be produced relative to weakly associated nouns. These results highlight a functional segregation within the left inferior frontal gyrus for verb generation. More generally, the findings suggest that both factors of selection between competing responses and association strength are important during single-word production with the latter factor becoming particularly critical when task-irrelevant stimuli interfere with the current task (here nouns during verb production), triggering additional activation of the BG. ■

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“…Yet other studies revealed that even though damage of the inferior frontal regions and the underlying structures usually impairs the morphosyntactic processing, this impairment is not necessarily specific for verb production or comprehension but can lead to problems of certain kind of morphological operations for words of different categories (FaroqiShah & Thompson, 2004;Marslen-Wilson & Tyler, 1997;Miceli, Silveri, Romani, & Caramazza, 1989;Ullman et al, 1997). Several fMRI studies showed a greater activation for verbs relative to nouns in the left posterior middle temporal gyrus and/or the left inferior frontal gyrus (Davis, Meunier, & Marslen-Wilson, 2004;Mestres-Missé et al, 2010;Shapiro et al, 2005;Yokoyama et al, 2006). On the other hand, the results of other fMRI studies (Berlingeri et al, 2008;Sahin, Pinker, & Halgren, 2006) demonstrated that nouns compared to verbs can show a greater activation in the left inferior frontal gyrus (IFG) (BA 44, 45 and 47) when the task is morphologically more demanding.…”

Section: Introductionmentioning

confidence: 99%