Cortical
miR-709
links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner
Konstantinos Kompotis,
Géraldine M. Mang,
Jeffrey Hubbard
et al.
Abstract:MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that have been implicated in a plethora of neuronal processes. Nevertheless, their role in regulating brain activity in the context of sleep has so far received little attention. To test their involvement, we deleted mature miRNAs in post-mitotic neurons at two developmental ages, i.e., in early adulthood using conditional
Dicer
knockout (cKO) mice and in adult mice using an inducible conditional
D… Show more
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