Cortical hand bone loss after 1 year in early rheumatoid arthritis predicts radiographic hand joint damage at 5-year and 10-year follow-up

Hoff, Mari; Haugeberg, Glenn; Ødegård, Sigrid; Syversen, Silje Watterdal; Landewé, Robert; Heijde, D. van der; Kvien, Tore K

doi:10.1136/ard.2007.085985

Cited by 109 publications

(101 citation statements)

References 39 publications

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“…radiogrammetry (DXR) [1], whereas presence of focal erosions is commonly evaluated by scoring radiographs according to the Sharp Heijde method [9]. In a previous study on the same cohort we found that plasma level of HGF, but not DKK1, was an independent predictor of radiographic damage of joints both at short-and long-term follow-up [10].…”

Section: Introductionmentioning

confidence: 99%

“…The study enrolled 238 patients with RA of less than four years disease duration in 1992 [1,11,12]. The study was performed in compliance with Helsinki declaration and approved by regional ethics committee (REK Sør-Øst, number 2009/1770a).…”

Section: Patientsmentioning

confidence: 99%

“…DXR-BMD was calculated based on hand radiographs taken at baseline and after 1, 2 and 5 years of observation. Least significant change (LSC) was used as a cut-off to define loss in DXR-BMD exceeding the measurement error on the individual level and calculated as previously reported [1].…”

Section: Radiographs and Dxr-bmdmentioning

confidence: 99%

“…Periarticular bone loss occurs within the bone adjacent to inflamed joints and has been shown to precede and predict development of erosions [1]. Inflammatory cytokines involved in osteoclast differentiation and activation is thought to be the dominant mechanism behind the development of both erosions and periarticular bone loss [2].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dickkopf-1 Is Associated with Periarticular Bone Loss in Patients with Rheumatoid Arthritis*

Grandaunet¹,

Syversen²,

Haugeberg³

et al. 2013

OJRA

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Objective: To examine whether cytokines shown to suppress osteoblasts, Dickkopf-1 (DKK1) and hepatocyte growth factor (HGF), are associated with periarticular bone loss in rheumatoid arthritis (RA). Methods: RA patients with short disease duration were prospectively followed and hand bone mineral density was assessed by digital X-ray radiogrammetry (DXR) at baseline and after 1, 2 and 5 years. Plasma samples collected at baseline from 136 of the included patients were analyzed for HGF and DKK1. Group comparisons, correlation analyses and multivariate analyses were performed to evaluate the relationship between baseline cytokine levels and DXR-BMD. Results: Patients with hand bone loss after 1 year had significantly higher baseline plasma levels of DKK1 than patients without bone loss. Patients with periarticular bone loss after 2 and 5 years had significantly higher baseline plasma levels of HGF. Baseline DKK1 but not HGF levels were independently associated with periarticular bone loss after 1 year. Conclusion: High serum levels of DKK1 are weakly but independently associated with periarticular bone loss in RA. The importance of DKK1 and HGF for loss of periarticular bone needs to be defined in future studies.

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Section: Introductionmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Radiographs and Dxr-bmdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dickkopf-1 Is Associated with Periarticular Bone Loss in Patients with Rheumatoid Arthritis*

Grandaunet¹,

Syversen²,

Haugeberg³

et al. 2013

OJRA

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“…Hoff et al recently reported the prognostic ability of cortical hand bone mineral density (BMD) loss during the first year of disease in RA as assessed by digital x-ray radiogrammetry. Radiographic progression of erosions at both 5 and 10 years was significantly higher in those patients with early hand BMD loss compared with those without early BMD loss (4). Dual x-ray absorptiometry (DXA) is widely available and early reports from our group suggested that hand BMD loss as assessed by DXA was more sensitive to RA-related bone damage than conventional radiographic erosions (5).…”

Section: Introductionmentioning

confidence: 99%

Relationship between early bone mineral density changes and long‐term function and radiographic progression in rheumatoid arthritis

Bejarano¹,

Hensor²,

Green³

et al. 2011

Arthritis Care & Research

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Objective. To ascertain whether bone mineral density loss during the first year of treatment for early rheumatoid arthritis (RA) as assessed by dual x-ray absorptiometry (DXA) is associated with long-term function, quality of life, and radiographic progression. Methods. Early RA patients, prior to commencing disease-modifying antirheumatic drug therapy, underwent evaluation with DXA scans of both hands, femoral neck, and lumbar spine at the time of diagnosis, then at 1 year and final followup at >6 years. Clinical and laboratory data and hands and feet radiographs were obtained at baseline and final followup. Results. Sixty-four patients were assessed. At baseline, median disease duration was 6 months, mean 28-joint Disease Activity Score was 5.85, and median Health Assessment Questionnaire score was 1.38. Median followup was 6.4 years (range 5.1-7.2 years). For erosion scores, 86% of patients with hand bone density loss above the smallest detectable change after 1 year progressed versus 55% of those with no hand bone density loss (P ‫؍‬ 0.006). However, baseline radiographs showed a similar strength of association. Eighty-four percent of patients with erosions at baseline had erosion progression versus 57% of those with no baseline erosions (P ‫؍‬ 0.021). Additionally, first-year bone density loss was not associated with function and quality of life status at followup. Conclusion. Hand bone loss during the first year of treatment in early RA, as assessed with DXA, was associated with a high likelihood of radiographic progression; however, in the current study this was not superior to baseline radiographs. Furthermore, it was not associated with patient-reported outcomes.

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Inflammation‐Induced Bone Loss in the Rheumatic Diseases

Goldring¹

2013

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

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Cortical hand bone loss after 1 year in early rheumatoid arthritis predicts radiographic hand joint damage at 5-year and 10-year follow-up

Abstract: Early hand bone loss measured by DXR-BMD is an independent predictor of subsequent radiographic damage. Our findings support that quantitative hand bone loss in RA precedes radiographic joint damage and may be used as a tool for assessment of bone involvement in RA.

Cited by 109 publications

References 39 publications

Dickkopf-1 Is Associated with Periarticular Bone Loss in Patients with Rheumatoid Arthritis*

Dickkopf-1 Is Associated with Periarticular Bone Loss in Patients with Rheumatoid Arthritis*

Relationship between early bone mineral density changes and long‐term function and radiographic progression in rheumatoid arthritis

Inflammation‐Induced Bone Loss in the Rheumatic Diseases

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