Cortical Grey matter volume depletion links to neurological sequelae in post COVID-19 “long haulers”

Rothstein, Ted L.

doi:10.1186/s12883-023-03049-1

Cited by 21 publications

(13 citation statements)

References 102 publications

(158 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[68] A decrease in brain volume has also been observed in patients with long COVID. [69] There are functional and anatomical connections between the olfactory bulb and the medial prefrontal cortex (part of the frontal lobe). [70] Toniolo et al have described the SARS-CoV-2 virus as directly targeting the frontal lobes.…”

Section: Neuropsychiatric Manifestations Of Long Covidmentioning

confidence: 99%

Long COVID’s Impact on Patients, Workers, & Society: A review

Kavanagh,

Cormier,

Pontus

et al. 2024

Medicine

View full text Add to dashboard Cite

The incidence of long COVID in adult survivors of an acute SARS-CoV-2 infection is approximately 11%. Of those afflicted, 26% have difficulty with day-to-day activities. The majority of long COIVD cases occur after mild or asymptomatic acute infection. Children can spread SARS-CoV-2 infections and can also develop long-term neurological, endocrine (type I diabetes), and immunological sequelae. Immunological hypofunction is exemplified by the recent large outbreaks of respiratory syncytial virus and streptococcal infections. Neurological manifestations are associated with anatomical brain damage demonstrated on brain scans and autopsy studies. The prefrontal cortex is particularly susceptible. Common symptoms include brain fog, memory loss, executive dysfunction, and personality changes. The impact on society has been profound. Fewer than half of previously employed adults who develop long COVID are working full-time, and 42% of patients reported food insecurity and 20% reported difficulties paying rent. Vaccination not only helps prevent severe COVID-19, but numerous studies have found beneficial effects in preventing and mitigating long COVID. There is also evidence that vaccination after an acute infection can lessen the symptoms of long COVID. Physical and occupational therapy can also help patients regain function, but the approach must be “low and slow.” Too much physical or mental activity can result in post-exertional malaise and set back the recovery process by days or weeks. The complexity of long COVID presentations coupled with rampant organized disinformation, have caused significant segments of the public to ignore sound public health advice. Further research is needed regarding treatment and effective public communication.

show abstract

Section: Neuropsychiatric Manifestations Of Long Covidmentioning

confidence: 99%

Long COVID’s Impact on Patients, Workers, & Society: A review

Kavanagh,

Cormier,

Pontus

et al. 2024

Medicine

View full text Add to dashboard Cite

show abstract

“…75 Brain imaging using magnetic resonance imaging and magnetic resonance imaging with diffusion tensor imaging have identified differences in brain structures between patients who have recovered from acute COVID-19 and controls. [78][79][80] In one study, self-reported memory loss correlated with changes in total gray matter volume in general and at specific sites, along with global mean diffusivity of white matter. 79 Patients with neurologic symptoms after acute COVID-19 infection had "bloodbrain barrier (BBB) impairment, elevated microglia activation markers, and a polyclonal B cell response targeting self-antigens and non-self-antigens" 81 along with significantly higher median interferon γ in cerebrospinal fluid.…”

Section: Cognitive Impairment or 2 Orthostatic Intolerancementioning

confidence: 99%

Long COVID—ACOEM Guidance Statement

Stave,

Nabeel,

Durand-Moreau

2024

J Occup Environ Med

View full text Add to dashboard Cite

Persistent symptoms are common after acute COVID-19, often referred to as long COVID. Long COVID may affect the ability to perform activities of daily living, including work. Long COVID occurs more frequently in those with severe acute COVID-19. This guidance statement reviews the pathophysiology of severe acute COVID-19 and long COVID and provides pragmatic approaches to long COVID symptoms, syndromes, and conditions in the occupational setting. Disability laws and workers’ compensation are also addressed.

show abstract

“…A CDC study recently found that risk of newly diagnosed diabetes in children that had been diagnosed with COVID-19 was more than twice as high (Barrett, 2022). Additional long-term impacts of the virus may include brain shrinkage (Rothstein, 2022), cognitive deficits (Hampshire et al, 2022), risk of heart disease and stroke (Sidik, 2022), reduced kidney functioning (Windpessl et al, 2021), liver damage (Wang et al, 2021), and impact on the endocrine system (Somasundaram et al, 2020). Preliminary evidence suggests that more recent variants may be worse for long COVID than earlier strains of the virus (Office for National Statistics, 2022).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of high-risk conditions for severe COVID-19 among Medicaid-enrolled children with autism and mental health diagnoses in the United States

Schott

Tao

Shea

2023

Autism

View full text Add to dashboard Cite

Children are at risk of short- and long-term morbidity and mortality from COVID-19. We examine whether autistic children and children with mental health conditions have higher odds of underlying health conditions at high risk of severe disease from COVID-19. We use claims data from a national sample of Medicaid-enrolled children for the years 2008–2016. We examine (1) children with claims for autism and (2) a random sample of children covered by Medicaid, without autism claims but with mental health condition. The comparison group is a random sample of children without autism or any mental health condition. There were 888,487 autistic children, 423,397 with mental health conditions (but not autism or intellectual disability), and 932,625 children without autism or mental health condition. We found 29.5% of autistic children and 25.2% of children with mental health conditions had an underlying condition with high risk for severe illness from COVID, compared to 14.1% of children without these diagnoses. Autistic children had higher odds of having any underlying condition (odds ratio = 2.17; 99% confidence interval = 2.14–2.20), as did children with mental health conditions (odds ratio = 1.71; 99% confidence interval = 1.68–1.73), adjusting for basic demographic characteristics. Children with diagnoses of autism and mental health conditions may be at higher risk for severe COVID due to high-risk condition prevalence. Lay abstract Children are at risk of varying severity of illness and even death from COVID-19. We aim to determine whether autistic children or children with mental health conditions have more underlying health conditions that put people at risk of severe illness from COVID-19. We use data from a national sample of Medicaid-enrolled children for the years 2008–2016. These data include children across the 50 states and the District of Columbia. We compare the prevalence of underlying conditions among autistic children and children with mental health condition to that of other children in Medicaid. This study included 888,487 autistic children, 423,397 with any mental health condition (but not autism), and 932,625 children without any of these diagnoses. We found 29.5% of autistic children and 25.2% of children with mental health conditions had an underlying condition with high risk for severe illness from COVID, compared to 14.1% of children without these diagnoses. Autistic children had over twice the odds of having any underlying conditions, when accounting for age, race, sex, and other characteristics. Children with mental health conditions had 70% higher odds of having these underlying conditions. Mitigation measures in schools and other areas could minimize risk of short- and long-term impacts from COVID for autistic and all children.

show abstract

Cortical Grey matter volume depletion links to neurological sequelae in post COVID-19 “long haulers”

Cited by 21 publications

References 102 publications

Long COVID’s Impact on Patients, Workers, & Society: A review

Long COVID’s Impact on Patients, Workers, & Society: A review

Long COVID—ACOEM Guidance Statement

Prevalence of high-risk conditions for severe COVID-19 among Medicaid-enrolled children with autism and mental health diagnoses in the United States

Contact Info

Product

Resources

About