Cortical excitability in patients with essential tremor

Romeo, Stefano; Berardelli, Alfredo; Pedace, F.; Inghilleri, Maurizio; Giovannelli, Morena; Manfredi, M.

doi:10.1002/(sici)1097-4598(199810)21:10<1304::aid-mus9>3.0.co;2-f

Cited by 30 publications

(22 citation statements)

References 25 publications

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“…[5][6][7][8][9] Previous studies using single and paired pulse TMS showed that in patients with Parkinson disease (PD), DBS of the globus pallidus internus (GPi) or subthalamic nucleus caused changes in cortical inhibitory circuits. 7,8 TMS studies also found normal excitability of the cerebellothalamocortical pathway 10 and normal motor cortical excitability 11 in patients with essential tremor.…”

supporting

confidence: 91%

Changes in cortical excitability with thalamic deep brain stimulation

et al. 2005

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supporting

confidence: 91%

Changes in cortical excitability with thalamic deep brain stimulation

et al. 2005

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“…27 Previous PET activation studies in patients with ET focused on the role of the cerebellum in tremor pathogenesis and found an abnormal activation of the cerebellum and red nuclei. 36 Although patients with ET without DBS have normal cortical motor area excitability according transcranial magnetic stimulation studies, 37 our results imply that effective VIM stimulation alters this situation. Our primary goal was to investigate the effects of DBS on cortical projections of the VIM and we therefore decided to scan superior parts of the brain.…”

Section: Methodsmentioning

confidence: 67%

Thalamic stimulation for essential tremor activates motor and deactivates vestibular cortex

Ceballos-Baumann

Boecker²,

Fogel³

et al. 2001

Neurology

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Beneficial effects of VIM stimulation in essential tremor are associated with increased synaptic activity in motor cortex, possibly due to nonphysiologic activation of thalamofrontal projections or frequency-dependent neuroinhibition. Retroinsular regional cerebral blood flow decreases suggest an interaction of VIM stimulation on vestibular-thalamic-cortical projections that may explain dysequilibrium, a common and reversible stimulation-associated side effect.

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“…The comparison of PWT with essential tremor is less clear‐cut. Romeo and coworkers16 reported that short‐ and long‐interval intracortical inhibition was normal in essential tremor, as we found here in PWT. However, conflicting results have been reported for spinal reciprocal inhibition.…”

Section: Discussionmentioning

confidence: 99%

Neurophysiological investigations in patients with primary writing tremor

et al. 2002

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The pathophysiology of primary writing tremor (PWT) is still unknown: it has been classified as a focal form of essential tremor and as a tremulous form of writer's cramp. We studied cortical and spinal excitability in patients with PWT and compared the results with published data of patients with essential tremor, and writer's cramp. We used electrical stimulation of median and radial nerve to study reciprocal inhibition of forearm antagonist muscles and paired transcranial magnetic stimulation at short and long interstimulus intervals (ISIs) to assess intracortical excitability. Both studies were conducted on patients with PWT and on control subjects. The early (presynaptic) and late (disynaptic) phases of reciprocal inhibition were normal as was intracortical excitability at short and long ISIs. Our study suggests that the pathophysiology of PWT is different from that of writer's cramp and partially also from that of essential tremor.

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Cortical excitability in patients with essential tremor

Cited by 30 publications

References 25 publications

Changes in cortical excitability with thalamic deep brain stimulation

Changes in cortical excitability with thalamic deep brain stimulation

Thalamic stimulation for essential tremor activates motor and deactivates vestibular cortex

Neurophysiological investigations in patients with primary writing tremor

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