Cortical evoked potentials in response to rapid balloon distension of the rectum and anal canal

Haas, Susanne; Brock, Christina; Krogh, Klaus; Gram, Mikkel; Nissen, Thomas; Lundby, Lilli; Laurberg, Søren; Drewes, Asbjørn Mohr

doi:10.1111/nmo.12341

Cited by 16 publications

(26 citation statements)

References 57 publications

(103 reference statements)

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“…Cortical evoked potentials deriving from the anal canal are compromised by latency jitter likely due to the sphincter tone, causing lower amplitude CEPs and subsequently poor reproducibility . Single sweep spectral band analysis, which is not influenced by jitter, is reproducible, however, at present we cannot align single sweeps and therefore latencies and amplitudes and topographical analysis can only be performed on the rectal data, not the data from the anal canal.…”

Section: Discussionmentioning

confidence: 93%

“…Exclusion criteria were the same as for IFI patients. From the group of 19 healthy women, 16 also participated in our previously published methodology study …”

Section: Methodsmentioning

confidence: 99%

“…Dipolar source analysis was used to guide inverse modeling revealing activated brain regions. Finally, as the CEPs from the anal canal are not synchronized, we used the spectral content of each single sweep in both the rectum and the anal canal to provide information on oscillations in the EEG signals in predefined frequency bands …”

Section: Methodsmentioning

confidence: 99%

“…In the present study, we hypothesized that patients with IFI have abnormal function of the afferent sensory pathways originating in the ano‐rectal region, and/or processing of the sensory stimuli in the brain. This was pursued using a newly developed method to study and characterize mechanically elicited cortical evoked potentials (CEPs) originating from the rectum and the anal canal using rapid balloon distension …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Abnormal neuronal response to rectal and anal stimuli in patients with idiopathic fecal incontinence

Haas

Brock

Krogh

et al. 2015

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 93%

“…Exclusion criteria were the same as for IFI patients. From the group of 19 healthy women, 16 also participated in our previously published methodology study …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Abnormal neuronal response to rectal and anal stimuli in patients with idiopathic fecal incontinence

Haas

Brock

Krogh

et al. 2015

Neurogastroenterology Motil

Self Cite

View full text Add to dashboard Cite

show abstract

“…This is a tedious and time-consuming process, which may be subject to bias and segmentation aided by semi-automatic software would be beneficial to reduce time. Furthermore, automatic methods are often superior to manual assessments in terms of reliability and may reduce inter-and intra-observer variability [13]. MRI of the unprepared colon complicates automatic segmentation as the contrast between the gut tissue and surrounding tissue is significantly reduced compared to imaging using contrast agents or bowel preparation.…”

mentioning

confidence: 98%

A novel semi-automatic segmentation method for volumetric assessment of the colon based on magnetic resonance imaging

et al. 2015

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Regional colon volumes were comparable to previous findings using fully manual segmentation. The method showed good agreement between observers and may be used in future studies of gastrointestinal disorders to assess colon and fecal volume and colon morphology. Novel insight into morphology and quantitative assessment of the colon using this method may provide new biomarkers for constipation and abdominal pain compared to radiography which suffers from poor reliability.

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Rectal sensitivity correlated with gastrointestinal‐mediated glucose disposal, but not the incretin effect

Meling,

Tjora,

Eichele

et al. 2023

Endocrino Diabet & Metabol

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ObjectiveThe mechanisms behind the diminished incretin effect in type 2 diabetes are uncertain, but impaired vagal transmission has been suggested. We aimed to investigate the association between the incretin effect and autonomic neuropathy, and the degree of dysglycaemia and duration of diabetes.Design and MethodsFor a cross‐sectional study, we included participants with either longstanding type 2 diabetes, recent onset, untreated diabetes and controls without diabetes matched for age, sex and body mass index. Autonomic nerve function was assessed with cardiovascular reflex tests, heart rate variability and sudomotor function. Visceral afferent nerves in the gut were tested performing rapid rectal balloon distention. An oral glucose tolerance test and an intravenous isoglycaemic glucose infusion were performed to calculate the incretin effect and gastrointestinal‐mediated glucose disposal (GIGD).ResultsSixty‐five participants were recruited. Participants with diabetes had rectal hyposensitivity for earliest sensation (3.7 ± 1.1 kPa in longstanding, 4.0 ± 1.3 in early), compared to controls (3.0 ± 0.9 kPa), p = .005. Rectal hyposensitivity for earliest sensation was not associated with the incretin effect (rho = −0.204, p = .106), but an association was found with GIGD (rho −0.341, p = .005). Incretin effect and GIGD were correlated with all glucose values, HbA1c and duration of diabetes.ConclusionsRectal hyposensitivity was uncovered in both longstanding and early type 2 diabetes, and was not associated with the incretin effect, but with GIGD, implying a potential link between visceral neuropathy and gastrointestinal handling of glucose. Both the incretin effect and GIGD were associated with the degree of dysglycaemia and the duration of diabetes.Previously PublishedSome of the data have previously been published and presented as a poster on the American Diabetes Association 83rd Scientific Sessions: Meling et al; 1658‐P: Rectal Hyposensitivity, a Potential Marker of Enteric Autonomic Nerve Dysfunction, Is Significantly Associated with Gastrointestinally Mediated Glucose Disposal in Persons with Type 2 Diabetes. Diabetes 20 June 2023; 72 (Supplement_1): 1658–P. https://doi.org/10.2337/db23‐1658‐P.

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Cortical evoked potentials in response to rapid balloon distension of the rectum and anal canal

Abstract: Cortical potentials evoked from the anal canal are challenged by latency jitter likely related to variability in muscle tone due to the distensions. Using single-sweep analysis, anal CEPs proved to be reproducible and should be used in future evaluation of the anal function.

Cited by 16 publications

References 57 publications

Abnormal neuronal response to rectal and anal stimuli in patients with idiopathic fecal incontinence

Abnormal neuronal response to rectal and anal stimuli in patients with idiopathic fecal incontinence

A novel semi-automatic segmentation method for volumetric assessment of the colon based on magnetic resonance imaging

Rectal sensitivity correlated with gastrointestinal‐mediated glucose disposal, but not the incretin effect

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