Cortical Evoked Potentials in Children of Diabetic Mothers

Brinciotti, M.; Napoli, Angela; Mittica, A.; Bitterman, Olimpia; Matricardi, M.

doi:10.1155/2011/640535

Cited by 13 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In CDMs, visual-evoked potentials and somatosensory-evoked potentials vary as a function of metabolic control during pregnancy with CDMs exhibiting delays in cortical evoked responses relative to children of non-diabetic mothers (31). Similar results have been previously obtained in our sample using electrophysiological measures.…”

Section: Discussionmentioning

confidence: 99%

Functional and Anatomic Consequences of Diabetic Pregnancy on Memory in Ten-Year-Old Children

Jabès

Thomas

Langworthy

et al. 2015

Journal of Developmental &Amp; Behavioral Pediatrics

View full text Add to dashboard Cite

Objective Pregnancies complicated by diabetes mellitus impair offspring memory functions during infancy and early childhood. The purpose of this study was to investigate the long term consequences of such pregnancies on memory and memory-related brain regions in 10-year-old children. Method Nineteen (19) children of diabetic mothers (CDMs) and thirty-five (35) children of non-diabetic mothers participated in this 10 year follow-up study. Memory performance was assessed using a continuous recognition memory task during which children made old/new judgments in response to pictures of concrete and abstract objects presented after different lags or delays. In addition, the volume of the hippocampal formation was measured using high resolution structural images. Results At 10 years of age, recognition memory performance of CDMs did not differ from children of non-diabetic mothers. Similarly, the volume of the hippocampal formation did not differ between groups. However, the size of the hippocampal formation in CDMs predicted the time those children needed to provide accurate responses in the continuous recognition memory task. Conclusion CDMs do not show memory impairments by 10 years of age, despite evidence for such impairments early in life. However, subtle differences in underlying neural processes may still be present. These results have important implications for long-term cognitive development of CDMs.

show abstract

Section: Discussionmentioning

confidence: 99%

Functional and Anatomic Consequences of Diabetic Pregnancy on Memory in Ten-Year-Old Children

Jabès

Thomas

Langworthy

et al. 2015

Journal of Developmental &Amp; Behavioral Pediatrics

View full text Add to dashboard Cite

show abstract

“…Reduced inner/outer macular thickness and total macular volume have been reported in children of diabetic mothers (8). Brinciotti et al (9) showed that type 1 DM mothers’ offspring had a significant delay of cortical evoked responses to visual stimulation compared with controls at both infancy and 3 years of age. Ricci et al (10) examined hypoplasia of iris stroma in 90% of infants with diabetic mothers and detected altered pupil dynamics in 85% of these infants in the first 3 days of life.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Refractive Error and Central Corneal Thickness in Neonates of Diabetic and Healthy Mothers

Göncü

Çakmak

Akal

et al. 2015

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Previous studies have determined the long‐term effects of maternal diabetes on the offspring of mothers with diabetes. These studies detected delayed cortical evoked responses in the visual and somatosensory systems of 3‐year‐old offspring of type 1 diabetic mothers and lower cognitive test scores in adult offspring of women with diet‐treated gestational diabetes (Brinciotti et al, 2011; Clausen et al, 2013).…”

Section: Methodsmentioning

confidence: 99%

Retardation of fetal dendritic development induced by gestational hyperglycemia is associated with brain insulin/IGF‐I signals

Jing

Song

Yao

et al. 2014

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Hyperglycemia is an essential risk factor for mothers and fetuses in gestational diabetes. Clinical observation has indicated that the offspring of mothers with diabetes shows impaired somatosensory function and IQ. However, only a few studies have explored the effects of hyperglycemia on fetal brain development. Neurodevelopment is susceptible to environmental conditions. Thus, this study aims to investigate the effects of maternal hyperglycemia on fetal brain development and to evaluate insulin and insulin-like growth factor-I (IGF-I) signals in fetal brain under hyperglycemia or controlled hyperglycemia. At day 1 of pregnancy, gestational rats were intraperitoneally injected with streptozocin (60 mg/kg). Some of the hyperglycemic gestational rats were injected with insulin (20 IU, two times a day) to control hyperglycemia; the others were injected with saline of equal volume. The gestational rats were sacrificed at days 14, 16, and 18 of embryo development. The dendritic spines of subplate cortex neurons in the fetal brain were detected by Golgi-Cox staining. The mRNA levels of insulin receptors (IRs) and IGF-IR in the fetal brain were measured using qRT-PCR. The protein levels of synaptophysin, IR, and IGF-IR in the fetal brain were detected by western blot. No significant difference in fetal brain formation was observed between the maternal hyperglycemic group and insulin-treated group. By contrast, obvious retardation of dendritic development in the fetus was observed in the maternal hyperglycemic group. Similarly, synaptophysin expression was lower in the fetus of the maternal hyperglycemic group than in that of the insulin-treated group. The mRNA and protein expression levels of IRs in the fetal brain were higher in the hyperglycemic group than in the insulin-treated group. By contrast, the levels of IGF-IR in the brain were lower in the fetus of the maternal hyperglycemic group than in that of the insulin-treated group. These results suggested that maternal hyperglycemia can retard dendritic development in the fetal brain and that these changes partially resulted from abnormal insulin/IGF-I signaling in the fetal brain.

show abstract

Cortical Evoked Potentials in Children of Diabetic Mothers

Cited by 13 publications

References 31 publications

Functional and Anatomic Consequences of Diabetic Pregnancy on Memory in Ten-Year-Old Children

Functional and Anatomic Consequences of Diabetic Pregnancy on Memory in Ten-Year-Old Children

Comparison of Refractive Error and Central Corneal Thickness in Neonates of Diabetic and Healthy Mothers

Retardation of fetal dendritic development induced by gestational hyperglycemia is associated with brain insulin/IGF‐I signals

Contact Info

Product

Resources

About