Cortical Effects of Aging and Hearing Loss

Mendelson, J. R.; Rajan, Ramesh

doi:10.1007/978-1-4419-0074-6_23

Cited by 1 publication

(2 citation statements)

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“…Functional loss of adult primate GABAergic function has been described in visual cortex (Betts et al, 2005; Leventhal et al, 2003; Schmolesky et al, 2000). Age-related changes suggestive of a loss of normal young adult GABAergic function in AI have been recently reviewed (Caspary et al, 2008; Mendelson and Rajan, 2011). Young and aged FBN rats show a fairly parallel (15–20dB) age-related threshold increase across frequencies (Caspary et al, 2005; Wang et al, 2009b).…”

Section: Discussionmentioning

confidence: 99%

“…Age-related functional changes in a number of sensory systems are strongly suggestive of a loss of normal adult inhibitory amino acid neurotransmission (Angelotti and Macdonald, 1993; Belelli et al, 2005; Burianova et al, 2009; for review Canlon et al, 2010; Caspary et al, 2008; Gutierrez et al, 1997; Lloyd et al, 1990; Maksay and Ticku, 1985; Malherbe et al, 1990; Mendelson and Rajan, 2011; Olsen et al, 1990; Pinto et al, 2010; Sakurai et al, 1994; Suta et al, 2011; Syka, 2002; Winer, 1992; Wisden et al, 1992; Ymer et al, 1990). In part, these changes in central inhibition likely reflect a compensatory age-related response to decreased peripheral sensory input, reflecting homeostatic plasticity (Noreña, 2011; Oliver et al, 2011; Richardson et al, 2011; Turrigiano and Nelson, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Age-related GABAA receptor changes in rat auditory cortex

Caspary¹,

Hughes²,

Ling³

2013

Neurobiology of Aging

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Auditory cortex (AI) shows age-related decreases in pre-synaptic markers for GABA and degraded AI neuronal response properties. Prior studies find age-related increases in spontaneous and driven activity, decreased spectral and directional sensitivity, and impaired novelty detection. The present study examined expression of GABAA receptor (GABAAR) subunit message, protein and quantitative GABAAR binding in young, middle-aged, and aged rat AI, with comparisons to adjoining parietal cortex. Significant loss of GABAAR α1 subunit message across AI layers was observed in middle-aged and aged rats while α1 subunit protein levels declined in layers II and III. Age-related increases in GABAAR α3 subunit message and protein levels were observed in certain AI layers. GABAAR subunits, including β1, β2, γ1, γ2s, and γ2L, primarily, but not exclusively, showed age-related declines at the message and protein levels. The ability of GABA to modulate [3H]TBOB binding in the chloride channel showed age-related decreases in peak binding and changes in desensitization kinetics. Collectively, age-related changes in GABAAR subunit composition would alter the magnitude and temporal properties of inhibitory synaptic transmission and could underpin observed age-related functional changes seen in the elderly.

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