“…For example, in a preliminary sample of cocaine-addicted individuals and healthy controls, we showed that dopamine D2 receptor availability, measured by positron emission tomography (PET) with [ 11 C]raclopride, correlated with fMRI midbrain response to errors during the color-word Stroop task when cognitive resources were presumably most depleted (during the final versus the first task repetition) (Moeller, Tomasi, Honorio, et al, 2012). In addition, studies administering the stop-signal tasks during PET with [ 18 F]fallypride in healthy individuals revealed correlations between SSRT and D2/D3 receptor availability in the left OFC, right MFG, and right precentral gyrus (Albrecht, Kareken, Christian, Dzemidzic, & Yoder, 2014) and the striatum (Ghahremani et al, 2012). Accordingly, therapeutic agents that act on this system, such as the indirect dopamine agonist methylphenidate, could be used to modulate the neural correlates of response inhibition in drug addiction as indeed previously demonstrated (Goldstein et al, 2010; Li et al, 2010; Moeller et al, 2014; Sofuoglu, Devito, Waters, & Carroll, 2013).…”