Cortical Correlates of Binaural Temporal Processing Deficits in Older Adults

Eddins, Ann Clock; Eddins, David A.

doi:10.1097/aud.0000000000000518

Cited by 30 publications

(29 citation statements)

References 31 publications

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“…The current results did not show any effect of hearing sensitivity on the IPM-FR or the binaural FM detection measures. Previous studies have not shown significant effects of high-frequency hearing sensitivity on low-frequency IPD discrimination using a variety of behavioral measures (Strelcyk and Dau, 2009;Grose and Mamo, 2012b;Moore et al, 2012;Eddins and Eddins, 2018), which is consistent with the current results. However, Vercammen et al (2018) did show that hearing sensitivity impacted the neural encoding of IPDs as measured by IPM-FRs elicited by a 492-Hz carrier tone, even after presentation levels were adjusted for audibility.…”

Section: Effects Of Age and Hearing Sensitivity On Binaural Processingsupporting

confidence: 92%

“…This study showed that age had a significant effect on IPM-FR magnitude and SNR. These findings are consistent with previous work (Vercammen et al, 2018) and provide additional evidence that age can impact the neural encoding of IPD cues (Ross et al, 2007a;Grose and Mamo, 2012a;Ozmeral et al, 2016;Papesh et al, 2017;Eddins and Eddins, 2018;Ungan et al, 2020). The IPM-FR is measured in response to IPD cues from temporal fine structure differences in an ongoing stimulus and is likely impacted by deficits in the extraction and integration of IPD information at the level of the brainstem.…”

Section: Effects Of Age and Hearing Sensitivity On Binaural Processingsupporting

confidence: 89%

“…Recent reports have focused on the use of non-invasive electrophysiological measures to assess the effects of age on the neural encoding of binaural temporal cues (Ross et al, 2007a;Ross, 2008;Wambacq et al, 2009;Grose and Mamo, 2012a;Ozmeral et al, 2016;Papesh et al, 2017;Eddins and Eddins, 2018;Vercammen et al, 2018;Ungan et al, 2020). For example, Ross et al (2007a) and Papesh et al (2017) recorded transient event-related potentials in response to a 180 • IPD using magnetoencephalography and electroencephalography, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Age-Related Deficits in Electrophysiological and Behavioral Measures of Binaural Temporal Processing

et al. 2020

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Binaural processing, particularly the processing of interaural phase differences, is important for sound localization and speech understanding in background noise. Age has been shown to impact the neural encoding and perception of these binaural temporal cues even in individuals with clinically normal hearing sensitivity. This work used a new electrophysiological response, called the interaural phase modulation-following response (IPM-FR), to examine the effects of age on the neural encoding of interaural phase difference cues. Relationships between neural recordings and performance on several behavioral measures of binaural processing were used to determine whether the IPM-FR is predictive of interaural phase difference sensitivity and functional speech understanding deficits. Behavioral binaural frequency modulation detection thresholds were measured to assess sensitivity to interaural phase differences while spatial release-from-masking thresholds were used to assess speech understanding abilities in spatialized noise. Thirty adults between the ages of 35 to 74 years with normal low-frequency hearing thresholds were used in this study. Data showed that older participants had weaker neural responses to the interaural phase difference cue and were less able to take advantage of binaural cues for speech understanding compared to younger participants. Results also showed that the IPM-FR was predictive of performance on the binaural frequency modulation detection task, but not on the spatial release-from-masking task after accounting the effects of age. These results confirm previous work that showed that the IPM-FR reflects age-related declines in binaural temporal processing and provide further evidence that this response may represent a useful objective tool for assessing binaural function. However, further research is needed to understand how the IPM-FR is related to speech understanding abilities.

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Section: Effects Of Age and Hearing Sensitivity On Binaural Processingsupporting

confidence: 92%

Section: Effects Of Age and Hearing Sensitivity On Binaural Processingsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Age-Related Deficits in Electrophysiological and Behavioral Measures of Binaural Temporal Processing

et al. 2020

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“…The variability across subjects in that study, however, was so great that they separated listeners into two groups—one with “large” BMLDs (approximately 18 dB) and one with “small” BMLDs (approximately 10 dB). BMLDs in the current study are closer to the small BMLD group of D. A. Eddins and Barber, whereas BMLDs in the A. C. Eddins and Eddins (2018) study are closer to the larger BMLD group of D. A. Eddins and Barber's study.…”

Section: Methodssupporting

confidence: 50%

A Comparison of Behavioral Methods for Indexing the Auditory Processing of Temporal Fine Structure Cues

Hoover

Kinney

Bell

et al. 2019

J Speech Lang Hear Res

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Purpose Growing evidence supports the inclusion of perceptual tests that quantify the processing of temporal fine structure (TFS) in clinical hearing assessment. Many tasks have been used to evaluate TFS in the laboratory that vary greatly in the stimuli used and whether the judgments require monaural or binaural comparisons of TFS. The purpose of this study was to compare laboratory measures of TFS for inclusion in a battery of suprathreshold auditory tests. A subset of available TFS tasks were selected on the basis of potential clinical utility and were evaluated using metrics that focus on characteristics important for clinical use. Method TFS measures were implemented in replication of studies that demonstrated clinical utility. Monaural, diotic, and dichotic measures were evaluated in 11 young listeners with normal hearing. Measures included frequency modulation (FM) tasks, harmonic frequency shift detection, interaural phase difference (TFS–low frequency), interaural time difference (ITD), monaural gap duration discrimination, and tone detection in noise with and without a difference in interaural phase (N 0 S 0 , N 0 S π ). Data were compared with published results and evaluated with metrics of consistency and efficiency. Results Thresholds obtained were consistent with published data. There was no evidence of predictive relationships among the measures consistent with a homogenous group. The most stable tasks across repeated testing were TFS–low frequency, diotic and dichotic FM, and N 0 S π . Monaural and diotic FM had the lowest normalized variance and were the most efficient accounting for differences in total test duration, followed by ITD. Conclusions Despite a long stimulus duration, FM tasks dominated comparisons of consistency and efficiency. Small differences separated the dichotic tasks FM, ITD, and N 0 S π . Future comparisons following procedural optimization of the tasks will evaluate clinical efficiency in populations with impairment.

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“…In these situations, the listener primarily relies on their binaural system to detect and process the cues necessary to determine the spatial location of the speech as well as cues to help segregate speech from the background competition. Unfortunately, known age-related declines in high-frequency hearing sensitivity (e.g., Allen & Eddins, 2010; Cruickshanks, Wiley, Tweed, Klein, Klein, Mares-Perlman, & Nondahl, 1998) and in the ability to process important monaural and binaural temporal fine structure and envelope features (Eddins & Eddins, 2017; Gallun et al, 2014; Gordon-Salant & Fitzgibbons, 1999; Grose & Mamo, 2010; Hopkins & Moore, 2009; Ozmeral, Eddins, Frisina, & Eddins, 2016) can have a significant impact on the ability of older adults to effectively access and use the cues needed for perception of auditory space and speech understanding in background competition.…”

Section: Introductionmentioning

confidence: 99%

How aging impacts the encoding of binaural cues and the perception of auditory space

2018

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Over the years, the effect of aging on auditory function has been investigated in animal models and humans in an effort to characterize age-related changes in both perception and physiology. Here, we review how aging may impact neural encoding and processing of binaural and spatial cues in human listeners with a focus on recent work by the authors as well as others. Age-related declines in monaural temporal processing, as estimated from measures of gap detection and temporal fine structure discrimination, have been associated with poorer performance on binaural tasks that require precise temporal processing. In lateralization and localization tasks, as well as in the detection of signals in noise, marked age-related changes have been demonstrated in both behavioral and electrophysiological measures and have been attributed to declines in neural synchrony and reduced central inhibition with advancing age. Evidence for such mechanisms, however, are influenced by the task (passive vs. attending) and the stimulus paradigm (e.g., static vs. continuous with dynamic change). That is, cortical auditory evoked potentials (CAEP) measured in response to static interaural time differences (ITDs) are larger in older versus younger listeners, consistent with reduced inhibition, while continuous stimuli with dynamic ITD changes lead to smaller responses in older compared to younger adults, suggestive of poorer neural synchrony. Additionally, the distribution of cortical activity is broader and less asymmetric in older than younger adults, consistent with the hemispheric asymmetry reduction in older adults model of cognitive aging. When older listeners attend to selected target locations in the free field, their CAEP components (N1, P2, P3) are again consistently smaller relative to younger listeners, and the reduced asymmetry in the distribution of cortical activity is maintained. As this research matures, proper neural biomarkers for changes in spatial hearing can provide objective evidence of impairment and targets for remediation. Future research should focus on the development and evaluation of effective approaches for remediating these spatial processing deficits associated with aging and hearing loss.

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Cortical Correlates of Binaural Temporal Processing Deficits in Older Adults

Cited by 30 publications

References 31 publications

Age-Related Deficits in Electrophysiological and Behavioral Measures of Binaural Temporal Processing

Age-Related Deficits in Electrophysiological and Behavioral Measures of Binaural Temporal Processing

A Comparison of Behavioral Methods for Indexing the Auditory Processing of Temporal Fine Structure Cues

How aging impacts the encoding of binaural cues and the perception of auditory space

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