Cortical contributions to the auditory frequency-following response revealed by MEG

Coffey, Emily B. J.; Herholz, Sibylle C.; Chepesiuk, Alexander M. P.; Baillet, Sylvain; Zatorre, Robert J.

doi:10.1038/ncomms11070

Cited by 338 publications

(443 citation statements)

References 68 publications

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“…Interestingly, no significant differences were found between the left STG and other brain areas, supporting the notion of an asymmetry favoring the right auditory cortex in music processing. Indeed, the right auditory cortex and related networks have been consistently implicated in various processes relevant for music perception, including pitch representation (29)(30)(31), tonal pattern processing (32,33), tonal working memory (34,35), tonal learning (36,37), and musical imagery (38). These cognitive processes would be important not just in decoding musical patterns but also in generating the expectancies that we believe are critical to generating musical pleasure (39).…”

Section: Discussionmentioning

confidence: 96%

Neural correlates of specific musical anhedonia

Martínez‐Molina

Mas‐Herrero

Rodrı́guez-Fornells

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Although music is ubiquitous in human societies, there are some people for whom music holds no reward value despite normal perceptual ability and preserved reward-related responses in other domains. The study of these individuals with specific musical anhedonia may be crucial to understand better the neural correlates underlying musical reward. Previous neuroimaging studies have shown that musically induced pleasure may arise from the interaction between auditory cortical networks and mesolimbic reward networks. If such interaction is critical for music-induced pleasure to emerge, then those individuals who do not experience it should show alterations in the cortical-mesolimbic response. In the current study, we addressed this question using fMRI in three groups of 15 participants, each with different sensitivity to music reward. We demonstrate that the music anhedonic participants showed selective reduction of activity for music in the nucleus accumbens (NAcc), but normal activation levels for a monetary gambling task. Furthermore, this group also exhibited decreased functional connectivity between the right auditory cortex and ventral striatum (including the NAcc). In contrast, individuals with greater than average response to music showed enhanced connectivity between these structures. Thus, our results suggest that specific musical anhedonia may be associated with a reduction in the interplay between the auditory cortex and the subcortical reward network, indicating a pivotal role of this interaction for the enjoyment of music.Without music, life would be a mistake.Friedrich Nietzsche, Twilight of the Idols T his quote highlights the importance of music for the life of most people. Indeed, although music is not a primary reward (such as food or sex), it is reckoned as one of the most important sources of pleasure in life. Furthermore, music has been present in human societies since prehistory (1), and most of the current literature on music psychology has described it as a universal reward for human beings (2). Its ubiquity and antiquity prove the importance of music in our society (3).Paradoxically, not everybody loves music: A small percentage of healthy individuals do not find music pleasurable, a phenomenon known as specific musical anhedonia (4). A detailed study on this population revealed that this phenomenon cannot be explained by perceptual problems [e.g., hearing impairment or specific impairment in perceptual capabilities, a condition known as amusia (5)] or by general anhedonia (lack of pleasure for all types of rewarding stimuli). When listening to music rated as pleasant by others, people with specific musical anhedonia showed a reduced emotional arousal as indexed by autonomic nervous system activity [in particular, skin conductance response (SCR) and heart rate measurements] compared with people having standard or high sensitivity to music. Notably, they showed normal responses to other types of reward [e.g., money (4)]. Therefore, individuals with specific musical anhedonia represent an idea...

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Section: Discussionmentioning

confidence: 96%

Neural correlates of specific musical anhedonia

Martínez‐Molina

Mas‐Herrero

Rodrı́guez-Fornells

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

152

181

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“…Until recently, the auditory brainstem was considered functionally mature by age two (Abdala and Folsom, 1995; Spitzer et al, 2015); several studies, however, point to a more prolonged developmental window of the auditory brainstem that continues into adolescence (Krizman et al, 2015; Skoe et al, 2015). The frequency following response, the metric used in this study, has been recognized for its subcortical contributions, yet recent evidence demonstrates there are cortical contributions as well (Coffey et al, 2016). These findings support the notion that the FFR is representative of different levels of auditory processing.…”

Section: Discussionmentioning

confidence: 99%

Individual differences in speech-in-noise perception parallel neural speech processing and attention in preschoolers

et al. 2017

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From bustling classrooms to unruly lunchrooms, school settings are noisy. To learn effectively in the unwelcome company of numerous distractions, children must clearly perceive speech in noise. In older children and adults, speech-in-noise perception is supported by sensory and cognitive processes, but the correlates underlying this critical listening skill in young children (3–5 year olds) remain undetermined. Employing a longitudinal design (two evaluations separated by ~12 months), we followed a cohort of 59 preschoolers, ages 3.0–4.9, assessing word-in-noise perception, cognitive abilities (intelligence, short-term memory, attention), and neural responses to speech. Results reveal changes in word-in-noise perception parallel changes in processing of the fundamental frequency (F0), an acoustic cue known for playing a role central to speaker identification and auditory scene analysis. Four unique developmental trajectories (speech-in-noise perception groups) confirm this relationship, in that improvements and declines in word-in-noise perception couple with enhancements and diminishments of F0 encoding, respectively. Improvements in word-in-noise perception also pair with gains in attention. Word-in-noise perception does not relate to strength of neural harmonic representation or short-term memory. These findings reinforce previously-reported roles of F0 and attention in hearing speech in noise in older children and adults, and extend this relationship to preschool children.

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“…For AMF of 45 Hz, correlations were not significant in either young or aged animals. Contributions from the auditory cortex may be involved at 45 Hz AMF as well as lower AMFs that could decorrelate the two measures [Joris et al, 2004, Coffey et al, 2016, Coffey et al, 2017]. For AMFs of 128 and 256 Hz, correlations of ABR wave V amplitudes versus EFR amplitudes were significant in the aged but not in young animals.…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in envelope-following responses at equalized peripheral or central activation

Lai

Sommer

Bartlett

2017

Neurobiology of Aging

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Previous work has debated about comparisons of hearing abilities faced with alterations in hearing thresholds and evoked potentials between groups following acoustic trauma- or age-related changes. This study compares envelope following responses (EFRs) of young and aged rats when sound levels were matched according to (1) wave I amplitudes of auditory brainstem responses (ABRs) elicited by 8 kHz tones or (2) EFR amplitudes evoked by sinusoidally amplitude modulated (SAM) tones at 100 % depth. Matched wave I amplitudes across age corresponded to approximately 20 dB sound level differences. For matched wave I, no age-related differences were observed in wave V amplitudes. However, EFRs recorded in quiet were enhanced with aging at 100 % but not 25 % depth, consistent with enhanced central gain in aging. For matched EFRs, there were no age-related differences in EFRs of AM depth and AM frequency processing. These results suggest novel, objective measures beyond threshold to compensate for differences in auditory nerve activation and to differentiate peripheral and central contributions of EFRs.

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Cortical contributions to the auditory frequency-following response revealed by MEG

Cited by 338 publications

References 68 publications

Neural correlates of specific musical anhedonia

Neural correlates of specific musical anhedonia

Individual differences in speech-in-noise perception parallel neural speech processing and attention in preschoolers

Age-related changes in envelope-following responses at equalized peripheral or central activation

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