Cortical Bone Water: In Vivo Quantification with Ultrashort Echo-Time MR Imaging

Techawiboonwong, Aranee; Song, Hee Kwon; Leonard, Mary B.; Wehrli, Félix W.

doi:10.1148/radiol.2482071995

Cited by 201 publications

(226 citation statements)

References 33 publications

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“…The field is making steps in translating experience from animal and cadaveric experiments to in vivo human studies (123)(124)(125)(126). As bone water is present mainly in the pore system of bone, this parameter provides a surrogate measure for porosity, and it has been demonstrated that cortical bone water concentration is greater in postmenopausal women than in premenopausal women (127).…”

Section: Mrimentioning

confidence: 99%

Quantitative imaging methods in osteoporosis

Oei

Koromani

Rivadeneira

et al. 2016

Quant. Imaging Med. Surg.

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Section: Mrimentioning

confidence: 99%

Quantitative imaging methods in osteoporosis

Oei

Koromani

Rivadeneira

et al. 2016

Quant. Imaging Med. Surg.

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“…11 Furthermore, direct measurements of cortical bone water content using deuterium oxide or dehydration experiments report a void volume between 15 and 40%, suggesting an under-reporting of porosity. [21][22][23] To avoid exclusion of voxels that contain both void volume and bone matrix, a new approach has been developed, taking into account this process of partial volume effect.…”

Section: Definition and Measurement Of Cortical Porositymentioning

confidence: 99%

The clinical contribution of cortical porosity to fragility fractures

Bjørnerem

2016

BoneKEy Reports

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Cortical bone is not compact; rather it is penetrated by many Haversian and Volkmann canals for blood supply. The lining of these canals are the intracortical bone surfaces available for bone remodeling. Increasing intracortical bone remodeling increases cortical porosity. However, cortical bone loss occurs more slowly than trabecular loss due to the fact that less surface per unit of bone matrix volume is available for bone remodeling. Nevertheless, most of the bone loss over time is cortical because cortical bone constitutes 80% of the skeleton, and the relative proportion of trabecular bone diminishes with advancing age. Higher serum levels of bone turnover markers are associated with higher cortical porosity of the distal tibia and the proximal femur. Greater porosity of the distal radius is associated with higher odds for forearm fracture, and greater porosity of the proximal femur is associated with higher odds for non-vertebral fracture in postmenopausal women. Measurement of cortical porosity contributes to fracture risk independent of areal bone mineral density and Fracture Risk Assessment Tool. On the other hand, antiresorptive treatment reduces porosity at the distal radius and at the proximal femoral shaft. Thus, porosity is a substantial determinant of the bone fragility that underlies the risk of fractures and may be a target for fracture prevention.

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“…49 Unfortunately, the precise role of water in determining the mechanical competence of bone has not been determined. Analysis of water content shows a direct relationship between water and cortical porosity, which occurs with aging and osteoporosis ( Figure 7) and is a key feature of renal osteodystrophy 50 and its associated osteoporosis. It is assumed, but not yet demonstrated, that decreases in porosity caused by bisphosphonate treatment will result in a lesser water content in both osteoporosis and renal osteodystrophy.…”

Section: Bone Composition and Osteoporosis Al Boskeymentioning

confidence: 99%