Cortical auditory evoked responses of older adults with and without probable mild cognitive impairment

Lister, Jennifer J.; Bush, Aryn L. Harrison; Andel, Ross; Matthews, Courtney; Morgan, David; Edwards, Jerri D.

doi:10.1016/j.clinph.2015.11.007

Cited by 42 publications

(40 citation statements)

References 67 publications

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“…In agreement with the previous results by Lister et al (), both the traditional analyses and tsPCA solutions revealed no amplitude differences between the groups for P1. Although in the present study we did not find significant differences between the groups in the N1 and P2 amplitude analyzed through traditional, single‐electrode amplitude analysis, differences in the tsPCAs were found.…”

Section: Discussionsupporting

confidence: 93%

“…Our prior work examined whether CAEPs could be possible early indicators of MCI (Lister et al, ). In these follow‐up analyses, we have furthered our study of CAEPs in MCI by means of a more detailed analysis.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 42 participants comprised the final sample, with an age range between 61 and 87 years. Of these 42 participants, 23 were from the group of 30 participants in Lister et al (); seven participants from Lister et al were not included in the current study because of excessive noise in some electrodes to be included in the tsPCA.…”

Section: Methodsmentioning

confidence: 99%

“…Irimajiri, Golob, and Starr (2005) and Golob, Miranda, Johnson, and Starr (2001) showed results consistent with studies using active oddball tasks, such as larger P1 amplitudes for those with MCI relative to CNOAs, and no differences in N1 or P2, although the latter used a slightly different paradigm in which pure tone stimuli were presented in pairs. In contrast, Lister et al (2016) used both pure tones (in a similar paradigm as used by Irimajiri et al, 2005) and speech sounds (syllable/ba/) and found no differences between those with MCI and CNOA in P1 or N1. Instead, significantly smaller P2 amplitudes were obtained for participants with MCI than for CNOAs.…”

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confidence: 99%

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Cortical auditory evoked potentials in mild cognitive impairment: Evidence from a temporal‐spatial principal component analysis

et al. 2019

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Mild cognitive impairment (MCI) is considered an intermediate transitional stage for the development of dementia, especially Alzheimer's disease. The identification of neurophysiological biomarkers for MCI will allow improvement in detecting and tracking the progression of cognitive impairment. The primary objective of this study was to compare cortical auditory evoked potentials between older adults with and without probable MCI to identify potential neurophysiological indicators of cognitive impairment. We applied a temporal‐spatial principal component analysis to the evoked potentials achieved during the processing of pure tones and speech sounds, to facilitate the separation of the components of the P1‐N1‐P2 complex. The probable MCI group showed a significant amplitude increase in a factor modeling N1b for speech sounds (Cohen's d = .84) and a decrease in a factor around the P2 time interval, especially for pure tones (Cohen's d = 1.17). Moreover, both factors showed a fair discrimination value between groups (area under the curve [AUC] = .698 for N1b in speech condition; AUC = .746 for P2 in tone condition), with high sensitivity to detect MCI cases (86% and 91%, respectively). The results for N1b suggest that MCI participants may suffer from a deficit to inhibit irrelevant speech information, and the decrease of P2 amplitude could be a signal of cholinergic hypoactivation. Therefore, both components could be proposed as early biomarkers of cognitive impairment.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Cortical auditory evoked potentials in mild cognitive impairment: Evidence from a temporal‐spatial principal component analysis

et al. 2019

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“…Similarly, the reports about the effects of aging on the P2 amplitude were indifferent (Crowley & Colrain, ). However, the P2 wave may be more sensitive than N1 for aging and cognitive decline (Lister et al., ). Neuroplastic increase in auditory cortex responses has been found in a mouse model (Willott, Aitkin, & McFadden, ) and in noise‐exposed cat (Eggermont & Komiya, ) in which tonotopic cortical areas which were deprived of their high‐frequency input were recruited for larger responses at lower frequencies.…”

Section: Discussionmentioning

confidence: 99%

Speech‐in‐noise understanding in older age: The role of inhibitory cortical responses

Roß

Dobri

Schumann

2019

Eur J of Neuroscience

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Studies of central auditory processing underlying speech‐in‐noise (SIN) recognition in aging have mainly concerned the degrading neural representation of speech sound in the auditory brainstem and cortex. Less attention has been paid to the aging‐related decline of inhibitory function, which reduces the ability to suppress distraction from irrelevant sensory input. In a response suppression paradigm, young and older adults listened to sequences of three short sounds during MEG recording. The amplitudes of the cortical P30 response and the 40‐Hz transient gamma response were compared with age, hearing loss and SIN performance. Sensory gating, indicated by the P30 amplitude ratio between the last and the first responses, was reduced in older compared to young listeners. Sensory gating was correlated with age in the older adults but not with hearing loss nor with SIN understanding. The transient gamma response expressed less response suppression. However, the gamma amplitude increased with age and SIN loss. Comparisons of linear multi‐variable modeling showed a stronger brain–behavior relationship between the gamma amplitude and SIN performance than between gamma and age or hearing loss. The findings support the hypothesis that aging‐related changes in the balance between inhibitory and excitatory neural mechanisms modify the generation of gamma oscillations, which impacts on perceptual binding and consequently on SIN understanding abilities. In conclusion, SIN recognition in older age is less affected by central auditory processing at the level of sensation, indicated by sensory gating, but is strongly affected at the level of perceptual organization, indicated by the correlation with the gamma responses.

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Investigating auditory electrophysiological measures of participants with mild cognitive impairment and Alzheimer’s disease: A systematic review and meta‐analysis of event‐related potential studies

Tarawneh

Mulders

Sohrabi

et al. 2021

Alzheimer's & Dementia

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Background: Objectively measuring auditory functions has been proposed as an avenue in differentiating normal age-related cognitive dysfunction from Alzheimer's disease (AD) and its prodromal states. Previous research has suggested auditory eventrelated potentials (AERPs) to be non-invasive, cost-effective and efficient biomarkers for the diagnosis of AD. The objective of this paper is to review the published literature on AERPs measures in older adults diagnosed with AD and those at higher risk of developing AD, i.e., mild cognitive impairment (MCI) and subjective cognitive decline (SCD). Method:The search was performed on six major electronic databases (Ovid MED-LINE, OVID EMBASE, PsycINFO, PubMed, Scopus and CINAHL Plus). Articles identified prior to 7th May 2019 were considered for this review. A random effects metaanalysis and analysis of between study heterogeneity was conducted using the Comprehensive Meta-Analysis software. Result:The search identified 1076 articles; 74 articles met the full inclusion criteria and were included in the systematic review, and 47 articles were included into the analyses. Pooled analysis suggests that AD participants can be differentiated from controls due to significant delays in ABR, N100, P200, N200 and P300 latencies. P300 amplitude was significantly smaller in AD participants compared to controls. P300 latencies differed significantly between MCI participants and controls based on the pooled analysis. Conclusion:The findings of this review indicate that some AERPs may be valuable biomarkers of AD. In conjunction with currently available clinical and neuropsychological assessments, AERPs can aid in screening and diagnosis of prodromal AD.

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Cortical auditory evoked responses of older adults with and without probable mild cognitive impairment

Cited by 42 publications

References 67 publications

Cortical auditory evoked potentials in mild cognitive impairment: Evidence from a temporal‐spatial principal component analysis

Cortical auditory evoked potentials in mild cognitive impairment: Evidence from a temporal‐spatial principal component analysis

Speech‐in‐noise understanding in older age: The role of inhibitory cortical responses

Investigating auditory electrophysiological measures of participants with mild cognitive impairment and Alzheimer’s disease: A systematic review and meta‐analysis of event‐related potential studies

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