Cortical Auditory Evoked Potentials in Response to Frequency Changes with Varied Magnitude, Rate, and Direction

Vonck, Bernard M D; Lammers, Marc J. W.; Waals, Marjolijn van der; Zanten, G. A. Van; Versnel, Huib

doi:10.1007/s10162-019-00726-2

Cited by 12 publications

(15 citation statements)

References 41 publications

(86 reference statements)

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“…With an angle-change increase, N1′–P2′ amplitude showed an increasing trend, and N1′ and P2′ latency showed a shortening trend. This agreed with previous studies which used frequency or intensity as the stimulus for physical change ( Martin and Boothroyd, 2000 ; He et al, 2012 ; Vonck et al, 2019 ). A similar response trend was also reported in other electrophysiological spatial studies where increased lateralization via inserting earphones (e.g., larger binaural cues) caused a larger EEG response ( Ozmeral et al, 2019 ) or a stronger MEG attenuation ( Salminen et al, 2010 ).…”

Section: Discussionsupporting

confidence: 92%

Acoustic Change Complex Evoked by Horizontal Sound Location Change in Young Adults With Normal Hearing

Fan

Zhao²,

Sharma³

et al. 2022

Front. Neurosci.

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Acoustic change complex (ACC) is a cortical auditory-evoked potential induced by a change of continuous sound stimulation. This study aimed to explore: (1) whether the change of horizontal sound location can elicit ACC; (2) the relationship between the change of sound location and the amplitude or latency of ACC; (3) the relationship between the behavioral measure of localization, minimum audible angle (MAA), and ACC. A total of 36 normal-hearing adults participated in this study. A 180° horizontal arc-shaped bracket with a 1.2 m radius was set in a sound field where participants sat at the center. MAA was measured in a two-alternative forced-choice setting. The objective electroencephalography recording of ACC was conducted with the location changed at four sets of positions, ±45°, ±15°, ±5°, and ±2°. The test stimulus was a 125–6,000 Hz broadband noise of 1 s at 60 ± 2 dB SPL with a 2 s interval. The N1′–P2′ amplitudes, N1′ latencies, and P2′ latencies of ACC under four positions were evaluated. The influence of electrode sites and the direction of sound position change on ACC waveform was analyzed with analysis of variance. Results suggested that (1) ACC can be elicited successfully by changing the horizontal sound location position. The elicitation rate of ACC increased with the increase of location change. (2) N1′–P2′ amplitude increased and N1′ and P2′ latencies decreased as the change of sound location increased. The effects of test angles on N1′–P2′ amplitude [F(1.91,238.1) = 97.172, p < 0.001], N1′ latency [F(1.78,221.90) = 96.96, p < 0.001], and P2′ latency [F(1.87,233.11) = 79.97, p < 0.001] showed a statistical significance. (3) The direction of sound location change had no significant effect on any of the ACC peak amplitudes or latencies. (4) Sound location discrimination threshold by the ACC test (97.0% elicitation rate at ±5°) was higher than MAA threshold (2.08 ± 0.5°). The current study results show that though the ACC thresholds are higher than the behavioral thresholds on MAA task, ACC can be used as an objective method to evaluate sound localization ability. This article discusses the implications of this research for clinical practice and evaluation of localization skills, especially for children.

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Section: Discussionsupporting

confidence: 92%

Acoustic Change Complex Evoked by Horizontal Sound Location Change in Young Adults With Normal Hearing

Fan

Zhao²,

Sharma³

et al. 2022

Front. Neurosci.

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“…One candidate is the acoustic change complex (ACC), which is an obligatory cortical auditory evoked potential (CAEP) evoked by a change in an ongoing stimulus (Jerger & Jerger 1970 ; Martin & Boothroyd 1999 ). It can be recorded in an awake and passive listening situation and it has the same typical waveform as the cortical P1-N1-P2 complex observed in response to a stimulus onset ( Kim 2015 ; Martin & Boothroyd 2000 ; Vonck et al 2019 ). The ACC mirrors auditory discrimination ( Martin et al 2008 ) and might better relate to perceptual measures ( He et al 2012 , 2014 ; Kim 2015 ; Liang et al 2018 ; Mathew et al 2017 ) than other objective measures such as electrocochleography ( Kim et al 2017 ), electrically evoked compound action potentials ( Smoorenburg et al 2002 ; van Eijl et al 2017 ), electrically evoked auditory brainstem responses ( Lammers et al 2015a ), or CAEPs in response to onset stimuli ( Barlow et al 2016 ; Brown et al 2015 ; Lammers et al 2015 b).…”

Section: Introductionmentioning

confidence: 98%

“…In normal-hearing (NH) and hearing-impaired listeners the ACC can be acoustically evoked by changes in pure tones, e.g. in frequency or intensity ( Harris et al 2007 , 2008 ; Jerger & Jerger 1970 ; Pratt et al 2009 ; Vonck et al 2019 , 2021 ), changes in natural speech tokens ( Martin & Boothroyd 2000 ; Ostroff et al 1998 ; Tremblay et al 2003 ), or changes in more complex stimuli, like narrowband noise bursts with varying silent gap durations ( Lister et al 2007 ), or spectral-ripple stimuli ( Won et al 2011 ). More recently, several investigators examined the ACC in CI users and demonstrated that it can be reliably evoked by changes in frequencies within pure tones ( Liang et al 2018 ), speech stimuli ( Brown et al 2015 ; Friesen & Tremblay 2006 ), white noise stimuli with amplitude modulation changes ( Han & Dimitrijevic 2020 ), or spectral-ripple stimuli ( Won et al 2011 ).…”

Section: Introductionmentioning

confidence: 99%

The Acoustic Change Complex Compared to Hearing Performance in Unilaterally and Bilaterally Deaf Cochlear Implant Users

et al. 2022

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Objectives: Clinical measures evaluating hearing performance in cochlear implant (CI) users depend on attention and linguistic skills, which limits the evaluation of auditory perception in some patients. The acoustic change complex (ACC), a cortical auditory evoked potential to a sound change, might yield useful objective measures to assess hearing performance and could provide insight in cortical auditory processing. The aim of this study is to examine the ACC in response to frequency changes as an objective measure for hearing performance in CI users.Design: Thirteen bilaterally deaf and six single-sided deaf subjects were included, all having used a unilateral CI for at least 1 year. Speech perception was tested with a consonant-vowel-consonant test (+10 dB signal-to-noise ratio) and a digits-in-noise test. Frequency discrimination thresholds were measured at two reference frequencies, using a 3-interval, 2-alternative forced-choice, adaptive staircase procedure. The two reference frequencies were selected using each participant's frequency allocation table and were centered in the frequency band of an electrode that included 500 or 2000 Hz, corresponding to the apical electrode or the middle electrode, respectively. The ACC was evoked with pure tones of the same two reference frequencies with varying frequency increases: within the frequency band of the middle or the apical electrode (+0.25 electrode step), and steps to the center frequency of the first (+1), second (+2), and third (+3) adjacent electrodes.Results: Reproducible ACCs were recorded in 17 out of 19 subjects. Most successful recordings were obtained with the largest frequency change (+3 electrode step). Larger frequency changes resulted in shorter N1 latencies and larger N1-P2 amplitudes. In both unilaterally and bilaterally deaf subjects, the N1 latency and N1-P2 amplitude of the CI ears correlated to speech perception as well as frequency discrimination, that is, short latencies and large amplitudes were indicative of better speech perception and better frequency discrimination. No significant differences in ACC latencies or amplitudes were found between the CI ears of the unilaterally and bilaterally deaf subjects, but the CI ears of the unilaterally deaf subjects showed substantially longer latencies and smaller amplitudes than their contralateral normal-hearing ears. Conclusions:The ACC latency and amplitude evoked by tone frequency changes correlate well to frequency discrimination and speech perception capabilities of CI users. For patients unable to reliably perform behavioral tasks, the ACC could be of added value in assessing hearing performance.

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“…In general, latency measures are more sensitive in detecting changes in hearing function, whereas amplitudes are more dependent on the person’s attention as well as stimulus properties, such as stimulus intensity ( Pratt et al, 2009 ; Vonck et al, 2019 ). This is especially so for later CAEPs (N200 and P300), suggesting an earlier impact of hearing loss on higher-order (non-sensory) cortical processing, and later on lower-order (sensory) cortical processing (N100 and MMN) ( Oates et al, 2002 ).…”

Section: Resultsmentioning

confidence: 99%

Cortical Auditory Evoked Potentials in Cognitive Impairment and Their Relevance to Hearing Loss: A Systematic Review Highlighting the Evidence Gap

et al. 2021

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Background: Alzheimer’s disease (AD) is the most prevalent cause of dementia which affects a growing number of people worldwide. Early identification of people at risk to develop AD should be prioritized. Hearing loss is considered an independent potentially modifiable risk factor for accelerated cognitive decline and dementia in older adults. The main outcome of interest of this review is the alteration of Cortical Auditory Evoked Potential (CAEP) morphology in an AD or mild cognitive impairment (MCI) population with and without hearing loss.Methods: Two investigators independently and systematically searched publications regarding auditory processing on a cortical level in people with cognitive impairment (MCI or AD) with and without hearing loss. Only articles which mentioned at least one auditory elicited event-related potential (ERP) component and that were written in English or Dutch were included. Animal studies were excluded. No restrictions were imposed regarding publication date. The reference list of potential sources were screened for additional articles.Results: This systematic review found no eligible articles that met all inclusion criteria. Therefore, no results were included, resulting in an empty systematic review.Conclusion: In general, dysfunction – being either from cognitive or auditory origin – reduces CAEP amplitudes and prolongs latencies. Therefore, CAEPs may be a prognostic indicator in the early stages of cognitive decline. However, it remains unclear which CAEP component alteration is due to cognitive impairment, and which is due to hearing loss (or even both). In addition, vestibular dysfunction – associated with hearing loss, cognitive impairment and AD – may also alter CAEP responses. Further CAEP studies are warranted, integrating cognitive, hearing, and vestibular evaluations.

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Cortical Auditory Evoked Potentials in Response to Frequency Changes with Varied Magnitude, Rate, and Direction

Cited by 12 publications

References 41 publications

Acoustic Change Complex Evoked by Horizontal Sound Location Change in Young Adults With Normal Hearing

Acoustic Change Complex Evoked by Horizontal Sound Location Change in Young Adults With Normal Hearing

The Acoustic Change Complex Compared to Hearing Performance in Unilaterally and Bilaterally Deaf Cochlear Implant Users

Cortical Auditory Evoked Potentials in Cognitive Impairment and Their Relevance to Hearing Loss: A Systematic Review Highlighting the Evidence Gap

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