Cortical auditory evoked potentials, brain signal variability and cognition as biomarkers to detect the presence of chronic tinnitus

Cardon, Emilie; Vermeersch, Hanne; Joossen, Iris; Jacquemin, Laure; Mertens, Griet; Vanderveken, Olivier M.; Lammers, Marc J. W.; Heyning, Paul Van de; Rompaey, Vincent Van; Gilles, Annick

doi:10.1016/j.heares.2022.108489

Cited by 9 publications

(6 citation statements)

References 89 publications

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“…This result suggested that tinnitus patients were more disturbed by informational masking than normal adults in the auditory center and higher-level cognitive processing. This result is also consistent with the findings in the study by Cardon et al (2022) that patients with tinnitus differ from normal adults in cortical auditory evoked potentials, brain signal variability and delayed memory.…”

Section: Resultssupporting

confidence: 93%

“…However, does the central auditory system function abnormally in tinnitus patients with normal pure-tone hearing? At present, some researchers have explored the evidence of chronic tinnitus through cortical auditory evoked potentials, brain signal variability and delayed memory ( Cardon et al, 2022 ), but the underlying mechanism is still unclear. Furthermore, is there any effect on speech recognition performance under different masking conditions?…”

Section: Introductionmentioning

confidence: 99%

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Subjective tinnitus patients with normal pure-tone hearing still suffer more informational masking in the noisy environment

et al. 2022

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Subjective tinnitus patients experience more hearing difficulties than normal peers in complex hearing environments, even though most of these patients have normal pure-tone hearing thresholds. Using speech recognition tasks under different masking conditions can provide insight into whether the effects of tinnitus are lateralized and the mechanisms behind the effects. By simulating sound field recordings, we obtain a target speech sentence that can be perceived as presented on one side and noise or speech masking with or without spatial separation from it. Our study used the virtual sound field technique to investigate the difference in speech recognition ability between chronic subjective tinnitus patients and a normal-hearing control group under the four masking conditions (speech-spectrum noise masking or two-talker speech masking, with or without perceived spatial separation). Experiment 1 showed no differences for target speech perceived location (left or right), which rules out a lateralization of the effect of tinnitus patients. Experiment 2 further found that although tinnitus patients had weaker performance than normal people in very complex auditory scenarios, when the spatial cue of the target speech exists, they can make good use of this cue to make up for the original processing disadvantage and achieve a similar performance as the normal-hearing group. In addition, the current study distinguished the effects of informational masking and energetic masking on speech recognition in patients with tinnitus and normal hearing. The results suggest that the impact of tinnitus on speech recognition in patients is more likely to occur in the auditory center rather than the periphery.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Subjective tinnitus patients with normal pure-tone hearing still suffer more informational masking in the noisy environment

et al. 2022

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“…Lower rates, such as 85 Hz in Paul et al (2017), are typically associated with midbrain responses. These reduced responses towards more cortical regions were also observed by assessing cortical auditory evoked potentials (Cardon et al, 2022). Additionally, we presented a RAM-stimulus instead of the sinusoidal modulation envelope used in Paul et al (2017), because RAM-stimuli are less sensitive to OHC-damage and more sensitive to CS (Vasilkov et al, 2021).…”

Section: Discussionmentioning

confidence: 79%

The role of hidden hearing loss in tinnitus: insights from early markers of peripheral hearing damage

Devolder,

Keppler,

Keshishzadeh

et al. 2024

Preprint

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Since the presence of tinnitus is not always associated with audiometric hearing loss, it has been hypothesized that hidden hearing loss may act as a potential trigger for increased central gain along the neural pathway leading to tinnitus perception. In recent years, the study of hidden hearing loss has improved with the discovery of cochlear synaptopathy and several objective diagnostic markers. This study investigated three potential markers of peripheral hidden hearing loss in subjects with tinnitus: extended high-frequency audiometric thresholds, the auditory brainstem response, and the envelope following response. In addition, speech intelligibility was measured as a functional outcome measurement of hidden hearing loss. To account for age-related hidden hearing loss, participants were grouped according to age, presence of tinnitus, and audiometric thresholds. Group comparisons were conducted to differentiate between age- and tinnitus-related effects of hidden hearing loss. All three markers revealed age-related differences, whereas no differences were observed between the tinnitus and non-tinnitus groups. However, the older tinnitus group showed improved performance on low-pass filtered speech in noise tests compared to the older non-tinnitus group. These low-pass speech in noise scores were significantly correlated with tinnitus distress, as indicated using questionnaires, and could be related to the presence of hyperacusis. Based on our observations, cochlear synaptopathy does not appear to be the underlying cause of tinnitus. The improvement in low-pass speech-in-noise could be explained by enhanced temporal fine structure encoding or hyperacusis. Therefore, we recommend that future tinnitus research takes into account age-related factors, explores low-frequency encoding, and thoroughly assesses hyperacusis.

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“…The above results indicate that the group-time interaction had no significant effect on P300 peak latency. After being educated, the subjects’ cognition of garbage classification was significantly improved, resulting in further improvement in the working memory to identify different garbage categories [ 66 , 67 ]. The specific performance shows that the response time for the classification judgement is reduced, and the intervention of interactive learning has the best effect.…”

Section: Resultsmentioning

confidence: 99%

Different Educational Interventions on Individual Cognition of Garbage Classification Based on EEG Monitoring

Zhao

Ren

Liu

et al. 2022

IJERPH

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Improvement in an individuals’ cognition is the key to promote garbage classification. This study takes university students as the research subjects, through three educational interventions, including the self-learning, heuristic learning, and interactive learning ways, to seek the most effective intervention based upon event-related potentials (ERPs) that is beneficial to enhance cognition of garbage classification. The results show that the experimental subjects induced P300 and LPP components, representing attentional changes and cognitive conflicts in classification judgments. There are differences in the amplitudes and peak latency of the two components corresponding to different interventions, indicating that the three educational interventions are able to improve the individual’s cognition level of garbage classification within a certain period of time. The interactive-learning intervention triggers the largest amplitudes of P300 and LPP, as well as the smallest peak latency, indicating its effect is the best. Such results provide insight into the design for an appropriate strategy in garbage classification education. The study also shows that an EEG signal can be used as the endogenous neural indicator to measure the performance of garbage classification under different educational interventions.

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Cortical auditory evoked potentials, brain signal variability and cognition as biomarkers to detect the presence of chronic tinnitus

Cited by 9 publications

References 89 publications

Subjective tinnitus patients with normal pure-tone hearing still suffer more informational masking in the noisy environment

Subjective tinnitus patients with normal pure-tone hearing still suffer more informational masking in the noisy environment

The role of hidden hearing loss in tinnitus: insights from early markers of peripheral hearing damage

Different Educational Interventions on Individual Cognition of Garbage Classification Based on EEG Monitoring

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