Cortical auditory evoked potentials as an objective measure of behavioral thresholds in cochlear implant users

Visram, Anisa; Innes‐Brown, Hamish; El‐Deredy, Wael; McKay, Colette M.

doi:10.1016/j.heares.2015.04.012

Cited by 36 publications

(35 citation statements)

References 25 publications

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“…We observed a correlation between onset eERP threshold and behavioral T levels, which is consistent with results of previous studies (Chang et al, 2012; Lightfoot & Kennedy, 2006; Visram et al, 2015). This result suggested that the onset eERP holds promise as an objective tool for estimating T levels in ABI recipients.…”

Section: Discussionsupporting

confidence: 93%

“…Onset eERPs were expected to show increased amplitude and reduced latency as stimulation level increased. Results of this study showed that eERPs measured in all subjects had non-monotonic increases in amplitude as stimulation level increased, which is consistent with our hypothesis and results measured in CI users (Firszt et al, 2002; Visram et al, 2015). Amplitude saturation was observed for responses measured for electrodes 2 and 4 in S4 and electrode 18 in S3, which is consistent with results reported for CI users in Firszt et al (2002).…”

Section: Discussionsupporting

confidence: 92%

“…Further increases in stimulation levels caused amplitude saturation in some listeners. Changes in stimulation level show similar effects on eERP amplitudes measured in CI users (Firszt et al, 2002; Visram et al, 2015). The observation of similar level effects on response amplitude reported in NH listeners and CI users is not surprising.…”

Section: Introductionsupporting

confidence: 54%

“…Previous results have established an association between auditory perception and ERPs evoked by acoustic and electrical stimulation in human listeners (e.g. Chang et al, 2012; Cone & Whitaker, 2013; He et al, 2012; 2013, 2015a; Lightfoot & Kennedy, 2006; Visram et al, 2015). Additionally, morphological characteristics of onset eERPs that are associated with non-auditory sensations are different from those evoked by auditory stimulation in CI patients (He et al, 2012).…”

Section: Introductionmentioning

confidence: 90%

“…The association between the onset ERP and auditory detection threshold has been evaluated in NH listeners (Lightfoot & Kennedy, 2006), infants with sensorineural hearing loss (Chang et al, 2012), patients with auditory neuropathy spectrum disorder (He et al, 2012), and adult CI users (Visram et al, 2015). Results of these studies showed a strong correlation between thresholds measured using onset ERP measures and behavioral procedures.…”

Section: Introductionmentioning

confidence: 99%

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Electrically Evoked Auditory Event-Related Responses in Patients with Auditory Brainstem Implants: Morphological Characteristics, Test–Retest Reliability, Effects of Stimulation Level, and Association with Auditory Detection

McFayden

Teagle

et al. 2016

Ear &Amp; Hearing

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Objective This study aimed to 1) characterize morphological characteristics of the electrically-evoked cortical auditory event-related potentials (eERP) and explore the potential association between onset eERP morphology and auditory vs non-auditory stimulation; 2) assess test-retest reliability of onset eERPs; 3) investigate effects of stimulation level on onset eERPs; and 4) explore the feasibility of using the onset eERP to estimate the lowest stimulation level that can be detected for individual stimulating electrodes in patients with auditory brainstem implants (ABIs). Design Study participants included five children (S1-S5) and two adults (S6-S7) with unilateral Cochlear Nucleus 24M ABIs. Pediatric ABI recipients ranged in age from 2.6 to 10.2 years (mean: 5.2 years) at the time of testing. S6 and S7 were 21.2 and 24.6 years of age at the time of testing, respectively. S6 and S7 were diagnosed with neurofibromatosis II (NF2) and implanted with an ABI after a surgical removal of the tumors. All pediatric subjects received ABIs after being diagnosed with cochlear nerve deficiency. The lowest stimulation level that could be detected (behavioral T level) and the estimated maximum comfortable level (C level) was measured for individual electrodes using clinical procedures. For electrophysiological measures, the stimulus was a 100-ms biphasic pulse train that was delivered to individual electrodes in a monopolar-coupled stimulation mode at stimulation levels ranging from sub-threshold to C levels. Electrophysiological recordings of the onset eERP were obtained in all subjects. For studies evaluating the test-retest reliability of the onset eERP, responses were measured using the same set of parameters in two test sessions. The time interval between test sessions ranged from two to six months. The lowest stimulation level that could evoke the onset eERP was defined as the objective T level. Results Onset eERPs were recorded in all subjects tested in this study. Inter- and intra-subject variations in morphological characteristics of onset eERPs were observed. Onset eERPs with complex waveforms were recorded for electrodes that evoked non-auditory sensations, based on feedback from subjects, as well as for electrodes without any indications of non-auditory stimulations. Onset eERPs in patients with ABIs demonstrated good test-retest reliability. Increasing stimulation levels resulted in increased eERP amplitudes but showed inconsistent effects on response latencies in patients with ABIs. Objective and behavioral T levels were correlated. Conclusions eERPs could be recorded in both non-NF2 and NF2 patients with ABIs. eERPs in both ABI patient groups show inter- and intra-subject variations in morphological characteristics. However, onset eERPs measured within the same subject in this study tended to be stable across study sessions. The onset eERP can potentially be used to estimate behavioral T levels in patients with ABIs. Further studies with more adult ABI recipients are warranted to investigate whether th...

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Section: Discussionsupporting

confidence: 93%