Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass

Yu, Elaine W.; Carmody, Jill S.; Brooks, Daniel J.; Lajoie, Scott; Kaplan, Lee M.; Bouxsein, Mary L.

doi:10.1016/j.bone.2016.01.017

Cited by 22 publications

(11 citation statements)

References 39 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same conclusion can be drawn from the differences seen in trabecular bone in male mice. Although some of our findings showed lower trabecular number and higher trabecular separation in animals allocated to the SOY group, a finding that is seen in animal models that simulate bone loss patterns [26], the lack of differences across groups based on mechanical testing further suggest that these changes may have been observed at random.…”

Section: Discussionmentioning

confidence: 74%

Effects of dietary omega-3 fatty acids on bones of healthy mice

et al. 2019

View full text Add to dashboard Cite

Subtle differences were noted at the bones' microstructural level, however these are likely the result of random effects that do not translate into changes that are biologically relevant. Similarly, differences were not seen at the mechanical level, nor were they reflected in blood-based biomarkers of bone metabolism. Altogether, dietary consumption of PUFA do not seem to affect bone structure or metabolism in a healthy model of growing mice.

show abstract

Section: Discussionmentioning

confidence: 74%

Effects of dietary omega-3 fatty acids on bones of healthy mice

et al. 2019

View full text Add to dashboard Cite

show abstract

“…A previous study from our group demonstrated that obese, T2DM mice showed decreased serum levels of bone turnover biomarkers C-terminal telopeptide of type I collagen (CTX) and osteocalcin (OCN) 32 . Meanwhile, several studies agree that the expression levels of CTX, OCN and/or P1NP in bone are affected after gastric bypass 33 , 34 . The suggested alteration of the bone remodeling of both mice groups goes in line with the dramatic decrease of trabecular BV/TV found in this study, given the fact that the trabecular compartment is an area more metabolically active than the cortex, and prone to high levels of remodeling 35 .…”

Section: Discussionmentioning

confidence: 98%

Unraveling the compromised biomechanical performance of type 2 diabetes- and Roux-en-Y gastric bypass bone by linking mechanical-structural and physico-chemical properties

Marín

Papantonakis

Sels

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with obesity and hyperglycemia. Roux-en-Y gastric bypass (RYGB) surgery is a common treatment for severely obese patients and T2DM. Both RYGB and T2DM are linked to increased skeletal fragility, though the exact mechanisms are poorly understood. Our aim was to characterize the structural, mechanical and compositional properties of bones from diet-induced obese and RYGB-treated obese (bypass) mice to elucidate which the exact factors are contributing to the increased skeletal fragility. To achieve this, a combinatory approach including microfocus X-ray computed tomography, 3-point bending, finite element modeling and Raman spectroscopy, was used. Compared to aged-matched lean controls, the obese mice displayed decreased cortical thickness, trabecular bone loss, decreased stiffness and increased Young’s modulus. For the bypass mice, these alterations were even more pronounced, and additionally they showed low mineral-to-matrix ratio in the cortical endosteal area. Accumulation of the advanced glycation end-product (AGE) pentosidine was found in the cortex of obese and bypass groups and this accumulation was correlated with an increased Young’s modulus. In conclusion, we found that the increased fracture risk in T2DM- and post-RYGB bones is mainly driven by accumulation of AGEs and macro-structural alterations, generating biomechanical dysfunctionality.

show abstract

“…Changes in weight and body composition measures were more widely correlated with bone loss after SG than RYGB, which may suggest that mechanical unloading may play a more important role in the pathophysiology of bone loss after SG. Indeed, animal studies suggest that the mechanism of bone loss after RYGB is independent of weight loss (37, 38). RYGB, which bypasses the duodenum and proximal jejunum, is associated with impaired absorption of calcium and vitamin D, key determinants of bone health (34, 39).…”

Section: Discussionmentioning

confidence: 99%

Effects of Roux-en-Y gastric bypass and sleeve gastrectomy on bone mineral density and marrow adipose tissue

Bredella

Greenblatt

Eajazi

et al. 2017

Bone

Self Cite

142

133

View full text Add to dashboard Cite

Bariatric surgery is associated with bone loss but skeletal consequences may differ between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), the two most commonly performed bariatric procedures. Furthermore, severe weight loss is associated with high marrow adipose tissue (MAT); however, MAT is also increased in visceral adiposity. The purpose of our study was to determine the effects of RYGB and SG on BMD and MAT. We hypothesized that both bariatric procedures would lead to a decrease in BMD and MAT. We studied 21 adults with morbid obesity (mean BMI 44.1 ± 5.1 kg/m2) prior to and 12 months after RYGB (n=11) and SG (n=10). All subjects underwent DXA and QCT of the lumbar spine and hip to assess aBMD and vBMD. Visceral (VAT) and subcutaneous (SAT) adipose tissue was quantified at L1-2. MAT of the lumbar spine and femur was assessed by 1H-MR spectroscopy. Calcitropic hormones and bone turnover markers were determined. At 12 months after surgery, mean weight and abdominal fat loss was similar between the RYGB and SG groups. Mean serum calcium, 25(OH)-vitamin D, and PTH levels were unchanged after surgery and within the normal range in both groups. Bone turnover markers P1NP and CTX increased within both groups and P1NP increased to a greater extent in the RYGB group (p=0.03). There were significant declines from baseline in spine aBMD and vBMD within the RYGB and SG groups, although the changes were not significantly different between groups (p=0.3). Total hip and femoral neck aBMD by DXA decreased to a greater extent in the RYGB than the SG group (p<0.04) although the change in femoral vBMD by QCT was not significantly different between groups (p>0.2). MAT content of the lumbar spine and femoral diaphysis did not change from baseline in the RYGB group but increased after SG (p=0.03). Within the SG group, 12-month change in weight and VAT were positively associated with 12-month change in MAT (p<0.04), suggesting that subjects with less weight and VAT loss had higher MAT. In conclusion, RYGB and SG are associated with declines in lumbar spine BMD, however, the changes are not significantly different between the groups. RYGB may be associated with greater decline of aBMD at the total hip and femoral neck compared to SG. MAT content increased after SG and this was associated with lower weight and VAT loss.

show abstract

Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass

Cited by 22 publications

References 39 publications

Effects of dietary omega-3 fatty acids on bones of healthy mice

Effects of dietary omega-3 fatty acids on bones of healthy mice

Unraveling the compromised biomechanical performance of type 2 diabetes- and Roux-en-Y gastric bypass bone by linking mechanical-structural and physico-chemical properties

Effects of Roux-en-Y gastric bypass and sleeve gastrectomy on bone mineral density and marrow adipose tissue

Contact Info

Product

Resources

About