Cortical and subcortical gray matter bases of cognitive deficits in REM sleep behavior disorder

Rahayel, Shady; Postuma, Ronald B.; Montplaisir, Jacques; Marchand, Daphné Génier; Escudier, Frédérique; Gaubert, Malo; Bourgouin, P.; Carrier, Julie; Monchi, Oury; Joubert, Sven; Blanc‬, ‪Frederic; Gagnon, Jean‐François

doi:10.1212/wnl.0000000000005523

Cited by 75 publications

(89 citation statements)

References 49 publications

(80 reference statements)

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“…Moreover, EEG slowing was present only in those RBD patients who eventually developed dementia . Recently, our group showed that RBD patients with MCI had extensive frontal cortex thinning that spread to the cingulate and temporal cortices as well as reduced cortical volume in the sensorimotor cortex . In contrast, RBD patients without MCI had cortical thinning restricted to the frontal cortex .…”

Section: Discussionmentioning

confidence: 91%

How does dementia with Lewy bodies start? prodromal cognitive changes in REM sleep behavior disorder

Marchand

Postuma

Escudier

et al. 2018

Annals of Neurology

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Section: Discussionmentioning

confidence: 91%

How does dementia with Lewy bodies start? prodromal cognitive changes in REM sleep behavior disorder

Marchand

Postuma

Escudier

et al. 2018

Annals of Neurology

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“…Our results are in line with a previous work in healthy subjects that found a positive correlation between gray matter volume in right orbitofrontal and olfactory performance [30], highlighting the important role of this region in olfactory function. Using cortical thickness analysis, previous studies with IRBD reported lower performance on the UPSIT-40 to be correlated with bilateral orbitofrontal, left precentral [31] and occipital thinning [32]. Another study, assessing brain perfusion in IRBD, showed that performance in the UPSIT 12-item version was related to regional cerebral blood low reduction in the anterior parahippocampal gyri [33].…”

Section: Discussionmentioning

confidence: 98%

Comparing the accuracy and neuroanatomical correlates of the UPSIT-40 and the Sniffin’ Sticks test in REM sleep behavior disorder

Campabadal

Segura

Junqué

et al. 2019

Parkinsonism & Related Disorders

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A B S T R A C TBackground: Olfactory impairment increases the risk of developing neurodegenerative diseases in patients with idiopathic REM sleep behavior disorder (IRBD). Knowing the test properties of distinct olfactory measures could contribute to their selection for clinical or research purposes. Objective: To compare the accuracy in distinguishing IRBD patients from controls with the University of Pennsylvania Smell Identification Test (UPSIT-40) and Sniffin' Sticks Extended test, and to assess the gray-matter volume correlates of these tests. Method: Twenty-one patients with IRBD and 27 healthy controls were assessed using both olfactory tests. Independent logistic regressions were computed with diagnosis as a dependent variable and olfactory measures as predictive variables. Receiver operating characteristic curves were computed for each olfactory subtest. Diagnostic accuracy for IRBD was calculated according to the resulting optimal cut-off score. Structural MRI data, acquired with a 3T scanner, were analyzed with voxel-based morphometry. Results: Patients differed from controls in all olfactory measures. The Sniffin-Identification correctly classified 89.1% of cases; the UPSIT-40, 85.4%; the Sniffin-Discrimination, 82.6%; the Sniffin-Total, 81.8%; and the Sniffin-Threshold, 77.3%. Respective AUROC, optimal cut-off, sensitivity, and specificity for each test were: 0.902, ≤26, 85.7%, and 85.2% for the UPSIT-40; 0.884, ≤29, 89.5%, and 76.0% for the Sniffin-Total; 0.922, ≤11, 90.5%, and 88.0% for the Sniffin-Identification; 0.739, ≤4, 73.7%, and 76.0% for the Sniffin-Threshold; and 0.838, ≤11, 85.7%, and 76.0% for the Sniffin-Discrimination. UPSIT-40 scores correlated with gray-matter volumes in orbitofrontal regions in anosmic patients. Conclusions: UPSIT-40 and Sniffin' Identification showed similar discrimination accuracy, but only the UPSIT-40 showed structural correlates (p ≤ .05 FDR-corrected). dementia with Lewy bodies (DLB), Parkinson's disease (PD), or multiple system atrophy [2,3]. In this setting, IRBD has been described as the strongest and most specific clinical predictor of neurodegenerative disease available [4]. Therefore, there is a growing interest in finding clinical biomarkers of neurodegeneration in this prodromal disorder.Since olfactory loss has also been recognized as a premotor symptom of PD [5,6], it has been widely studied as a possible biomarker of neurodegeneration in IRBD [7]. In this sense, olfactory impairment in RBD has been reported in 35.7-97.0% of patients compared with

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“…This relationship between pRBD and cognitive/motor function is potentially modified by an individual's educational level. The association between RBD, cognitive deficits, and motor abnormalities has been well-recognized, but previous studies mostly focused on PSG-confirmed RBD cases in clinical settings (25)(26)(27). However, RBD patients in clinical settings could have a more severe form of RBD, hence could present entirely different characteristics from the general population, which has been least studied.…”

Section: Discussionmentioning

confidence: 99%

Education Moderates the Association of Probable REM Sleep Behavior Disorder With Cognitive and Motor Impairments in Community-Dwelling Older People

Chen

et al. 2020

Front. Neurol.

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Objectives: To investigate the relationship between probable rapid eye movement (REM) sleep behavior disorder (pRBD) and cognitive/motor impairments in a community-dwelling population and explore the moderating effects of education. Methods: In this cross-sectional study of the Beijing Longitudinal Study of Aging II (BLSA II), 4,477 subjects (≥55 years) fulfilled the inclusion criteria. pRBD was determined by the RBD Questionnaire-Hong Kong (RBDQ-HK). Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to test the global cognitive performance. Walking speed was used to measure motor function. Logistic regression was performed to assess the relationship between pRBD and cognitive/motor impairments and the moderating effects of education. Results: There were 147 participants (3.3%) with pRBD. Participants with pRBD showed increased risks for cognitive impairment [odds ratio (OR) = 1.88, 95% CI 1.24-2.85, p = 0.003], decreased gait speed (OR = 1.43, 95% CI 1.02-2.01, p = 0.03), but not for mild cognitive impairment (MCI) (measured by MoCA: OR = 1.01, 95% CI 0.68-1.50, p = 0.95; measured by MMSE: OR = 0.90, 95% CI 0.59-1.37, p = 0.62). Education modified the effect of pRBD on MCI (measured by MoCA: p < 0.001; measured by MMSE: p = 0.061) and gait speed (p = 0.008). Conclusions: Our findings suggest that pRBD increases the risk of cognitive/motor impairments for a community-dwelling older population, and education could alleviate the negative effects. These findings implicate that education may have beneficial effects on delaying the onset of cognitive/motor decline in pRBD subjects.

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Cortical and subcortical gray matter bases of cognitive deficits in REM sleep behavior disorder

Cited by 75 publications

References 49 publications

How does dementia with Lewy bodies start? prodromal cognitive changes in REM sleep behavior disorder

How does dementia with Lewy bodies start? prodromal cognitive changes in REM sleep behavior disorder

Comparing the accuracy and neuroanatomical correlates of the UPSIT-40 and the Sniffin’ Sticks test in REM sleep behavior disorder

Education Moderates the Association of Probable REM Sleep Behavior Disorder With Cognitive and Motor Impairments in Community-Dwelling Older People

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