Cortical and subcortical central neural pathways in respiratory sensations

Davenport, Paul W.; Vovk, Andrea

doi:10.1016/j.resp.2008.10.001

Cited by 195 publications

(184 citation statements)

References 118 publications

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“…In a second step, a small-volume analysis with a family-wise error correction (FWEsvc, P < .05) was used within a priori-determined bilateral regions of interest (ROI). ROIs were chosen according to (1) previous knowledge on regional GMV reductions in patients with COPD, 10,12 (2) structural brain changes in chronic pain syndromes, [19][20][21][22][23] and (3) functional relevance of areas in the processing of dyspnea, 13,14 fear/anxiety, and fear-avoidance behavior, [15][16][17] and the transmission/regulation of nociceptive input. 18,28 Specifically, analyzed ROIs consisted of the anterior cingulate cortex (ACC), midcingulate cortex (MCC), insula, HC, thalamus, and AMYG.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 However, results concerning gray matter volume (GMV) remain sparse and partly conflicting. 11,12 Notably, GMV reductions previously observed in patients with COPD included limbic and paralimbic brain areas such as cingulate cortex, insula, hippocampus (HC), and amygdala (AMYG), 10,12 which are not only involved in the processing of dyspnea, 13,14 but also in fear/anxiety and fear-avoidance behavior, [15][16][17] and in antinociception, that is, the downregulation of aversive nociceptive stimuli. 18 Comparable GMV reductions were demonstrated in patients chronically experiencing other aversive sensations, especially pain, [19][20][21][22][23] and these were associated with longer pain duration.…”

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confidence: 95%

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Structural Brain Changes in Patients With COPD

Esser

Stoeckel

Kirsten

et al. 2016

Chest

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 95%

Structural Brain Changes in Patients With COPD

Esser

Stoeckel

Kirsten

et al. 2016

Chest

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“…Nevertheless, some studies reported that respiration center is not only controlled by brainstem, but also regulated by other brain area [16][17][18]. Accordingly, we hypothesized that even the patients with other brain lesions (cortex, basal ganglia, cerebellum, and any lesions other than brainstem) were decreased respiratory control reaction during exercise.…”

Section: Discussionmentioning

confidence: 94%

An Analysis between Pre- and Post-exercise of the Respiratory and Metabolic State for the Acute and Subacute Stroke Patients

et al. 2017

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To evaluate oxygenation and metabolic state of the non-brainstem stroke patients after the moderate intensity exercise using arterial blood gas analysis (ABGA). Fifty-two stroke patients were recruited. All the subjects were to follow the instructions for the exercise, not suffered cardiopulmonary diseases before, and not diagnosed with brainstem disorders. They were ordered to maintain 70% heart rate of maximal heart rate during exercise and checked blood pressure, pulse rate, respiratory rate (RR), and ABGA before and after the exercise, respectively. O 2 saturation, PaO 2 , PaCO 2 , O 2 content, HCO 3 − , pH, and anion gap were compared between the exercise, and those data changes were performed correlation analysis into age and the time after stroke onset. The data comparison was also done into the subgroup of the severity of stroke using National Institutes of Health Stroke Scale (NIHSS). The statistically significant results were observed in the change of O 2 saturation, PaO 2 , PaCO 2 , O 2 content, HCO 3 − , pH, and anion gap after the exercise. The decrease of HCO 3 − and increase of RR were proportional to age, however the data showed no correlation with the NIHSS. These results suggest relatively preserved respiratory compensation mechanism and homeostatic effect to maintain metabolic balance among the non-brainstem stroke patients.

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“…Some of these pathways are shared across respiratory modalities, whereas activation of some neural areas is modality-specific. 9 Many brain imaging studies of dyspnea have been conducted using different techniques to induce dyspnea. Despite the use of different intervention techniques, a common predominant neural activity has been found in the insula, operculum, and frontal cortex areas; anterior and posterior cingulated cortices; cerebellum; thalamus; and amygdala.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the use of different intervention techniques, a common predominant neural activity has been found in the insula, operculum, and frontal cortex areas; anterior and posterior cingulated cortices; cerebellum; thalamus; and amygdala. 9,10 However, a common predominant activity during auditory stimuli has been found in the primary and secondary auditory cortices and insular cortex. 11 Because the cortical processing involved in auditory stimuli is partly consistent with that in dyspnea perception, 9-11 the respiratory peripheral neural afferents of dyspnea perception, activated by exercise, may interact with the neural circuit responsible for processing dyspnea.…”

Section: Introductionmentioning

confidence: 99%

Distractive Auditory Stimuli Alleviate the Perception of Dyspnea Induced by Low-Intensity Exercise in Elderly Subjects With COPD

2015

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BACKGROUND: Although recent studies have shown that distractive auditory stimuli (DAS) in the form of music increase adherence to exercise in subjects with COPD, the effect of DAS on dyspnea induced by low-intensity, constant-load exercise in elderly patients with COPD has not been elucidated. Therefore, the purpose of this study was to investigate the effect of DAS on the perception of dyspnea induced by low-intensity, constant-load exercise in elderly subjects with COPD. METHODS: We enrolled 16 male out-patients with COPD. Subjects completed cycling exercises with and without DAS at 40% maximum oxygen consumption. They were asked to rate their perception of dyspnea using the modified Borg scale every 3 min during exercise and every 1 min during the recovery period. RESULTS: Dyspnea perception during low-intensity exercise showed a significant correlation between the exercise condition (DAS and control) and exercise duration (P ‫؍‬ .04). Exercise-induced dyspnea perception under the DAS condition was significantly lower than that under the control condition from 18 min after the start of exercise to 3 min after the end of exercise (18, 20, 21, 22, and 23 min, P ‫؍‬ .01, P < .001, P ‫؍‬ .009, P ‫؍‬ .006, and P ‫؍‬ .006, respectively). However, oxygen consumption and ventilation in response to low-intensity exercise did not significantly differ in the DAS and control conditions (P ‫؍‬ .39 and .14, respectively) CONCLUSIONS: Our results suggest that DAS is a non-pharmacologic therapy that can be used to reduce the dyspneic sensation in elderly patients with COPD.

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Cortical and subcortical central neural pathways in respiratory sensations

Cited by 195 publications

References 118 publications

Structural Brain Changes in Patients With COPD

Structural Brain Changes in Patients With COPD

An Analysis between Pre- and Post-exercise of the Respiratory and Metabolic State for the Acute and Subacute Stroke Patients

Distractive Auditory Stimuli Alleviate the Perception of Dyspnea Induced by Low-Intensity Exercise in Elderly Subjects With COPD

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