2003
DOI: 10.1007/bf03402043
|View full text |Cite
|
Sign up to set email alerts
|

Cortical and Leptomeningeal Cerebrovascular Amyloid and White Matter Pathology in Alzheimer’s Disease

Abstract: Alzheimer's disease (AD) is characterized by neurofibrillary tangles and by the accumulation of β-amyloid (Aβ) peptides in senile plaques and in the walls of cortical and leptomeningeal arteries as cerebral amyloid angiopathy (CAA). There also is a significant increase of interstitial fluid (ISF) in cerebral white matter (WM), the pathological basis of which is largely unknown. We hypothesized that the accumulation of ISF in dilated periarterial spaces of the WM in AD correlates with the severity of CAA, with … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

9
184
0
1

Year Published

2005
2005
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 243 publications
(194 citation statements)
references
References 28 publications
9
184
0
1
Order By: Relevance
“…These findings confirm previous studies, which reported the occipital lobe to be the site preerentially affected with CAA, followed by either frontal, temporal, or parietal lobes [3,17,19,20,40,42,43,49,50,[54][55][56]. In contrast, other authors reported the frontal lobe to be most frequently involved in CAA [27,57].…”
Section: Discussionsupporting
confidence: 89%
See 2 more Smart Citations
“…These findings confirm previous studies, which reported the occipital lobe to be the site preerentially affected with CAA, followed by either frontal, temporal, or parietal lobes [3,17,19,20,40,42,43,49,50,[54][55][56]. In contrast, other authors reported the frontal lobe to be most frequently involved in CAA [27,57].…”
Section: Discussionsupporting
confidence: 89%
“…CAA seems to be most prominent in occipital, frontal, and temporal lobes, followed by parietal lobe and white matter, whereas basal ganglia and thalamus are usually spared [1,3,4,9,19,42,43,45,46]. Its occurrence in the cerebellum ranges from absent to frequent [16,42].…”
Section: Introductionmentioning
confidence: 91%
See 1 more Smart Citation
“…Although the positive correlation between CERAD/Braak stages and the severity of CapCAA is interesting, the question whether it represents an epiphenomen or an indicator of a pathogenic association between tau pathology and Ag deposition in capillary walls is unclear. The failure of fluid drainage may also be related to white matter pathology in AD [35] and may have implications for therapeutic strategies in the treatment of AD and related morphological findings [36]. Furthermore, the role of pericapillary/perivascular astroglia for Ag deposition in cerebral vessels remains to be elucidated.…”
Section: Discussionmentioning
confidence: 98%
“…The mechanisms underlying MRI-visible PVS are still unknown, but one potential explanation is that the diminished pulsatility of arterioles or blocking bulk flow impairs perivascular drainage, causing retrograde dilation of PVS. 12,27 Abnormal proteins in the PVS could also trigger perivascular inflammation and neurodegeneration. 12 The association between PVS severity and hypertension in this study suggests that hypertensive arteriopathy (including arteriolosclerosis) is consistent with diminished pulsatility of stiffened small vessels.…”
Section: -84mentioning
confidence: 98%