Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats

Vorobyov, Vasily; Schibaev, Nikolai; Kaptsov, Vladimir; Ковалев, Г. И.; Sengpiel, Frank

doi:10.1016/j.brainres.2011.01.107

Cited by 15 publications

(6 citation statements)

References 61 publications

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“…The discriminative power of low frequencies further extends over network characteristic 64 and has also been observed in the very low frequency range of EEG 70 . Further, some evidence of increased low frequency in one of the specific models of rats (SHR) used in our experiments has also been reported 71 .…”

Section: Methodssupporting

confidence: 68%

“…In other words, ANOVA can evaluate the importance of each parameter and FDA can obtain the combinatorial weights of parameters to maximize the difference caused by some common factor. ANOVA has been widely used in this research field, for example in 71 , however FDA has not often been used. Introducing an effective usage of FDA for discovering dominant biomarkers semi-automatically is one of the contributions of this study to the research field considered.…”

Section: Discussionmentioning

confidence: 99%

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Semi-Automated Biomarker Discovery from Pharmacodynamic Effects on EEG in ADHD Rodent Models

Yokota

Struzik

Jurica

et al. 2018

Sci Rep

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We propose a novel semi-automatic approach to design biomarkers for capturing pharmacodynamic effects induced by pharmacological agents on the spectral power of electroencephalography (EEG) recordings. We apply this methodology to investigate the pharmacodynamic effects of methylphenidate (MPH) and atomoxetine (ATX) on attention deficit/hyperactivity disorder (ADHD), using rodent models. We inject the two agents into the spontaneously hypertensive rat (SHR) model of ADHD, the Wistar-Kyoto rat (WKY), and the Wistar rat (WIS), and record their EEG patterns. To assess individual EEG patterns quantitatively, we use an integrated methodological approach, which consists of calculating the mean, slope and intercept parameters of temporal records of EEG spectral power using a smoothing filter, outlier truncation, and linear regression. We apply Fisher discriminant analysis (FDA) to identify dominant discriminants to be heuristically consolidated into several new composite biomarkers. Results of the analysis of variance (ANOVA) and t-test show benefits in pharmacodynamic parameters, especially the slope parameter. Composite biomarker evaluation confirms their validity for genetic model stratification and the effects of the pharmacological agents used. The methodology proposed is of generic use as an approach to investigating thoroughly the dynamics of the EEG spectral power.

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Section: Methodssupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Semi-Automated Biomarker Discovery from Pharmacodynamic Effects on EEG in ADHD Rodent Models

Yokota

Struzik

Jurica

et al. 2018

Sci Rep

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“…Thus, hippocampal neuropathology, including neuronal loss, mostly in the CA 1 subfield, and astrocyte reactivity has been reported in intact adult SHRs (Pietranera et al, 2006;Sabbatini et al, 2004). Vorobyov et al (2011) found that the EEG spectral profiles are similar in SHRs suffering from congenital hypertension and in KA-treated normotensive rats. In this regard, we have shown that naive and epileptic SHRs exhibit comparable anxiety level associated with low level of serotonin and dopamine in the hippocampus (Tchekalarova and Pechlivanova, 2011).…”

Section: Introductionmentioning

confidence: 97%

Strain-dependent effects of long-term treatment with melatonin on kainic acid-induced status epilepticus, oxidative stress and the expression of heat shock proteins

Atanasova¹,

Petkova²,

Pechlivanova³

et al. 2013

Pharmacology Biochemistry and Behavior

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“…Similarity between the EEG spectral profiles of SHRs suffering from congenital hypertension and that of KA-treated normotensive rats have been reported earlier [33] .…”

Section: Expert Hypothesismentioning

confidence: 53%

Finding a model for comorbidity between attention deficit hyperactivity disorder and epilepsy

2014

Mol Cell Epilepsy

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Close relationships between attention deficit hyperactivity disorder (ADHD) and epilepsy has been suggested due to prevalence of ADHD symptoms among patients with epilepsy than in the general population. Like epilepsy-depression connection, bi-directional relationships are suggested to underlie the predisposition of patients with ADHD to epilepsy and vice versa. Spontaneously hypertensive rats (SHRs) are characterized with typical behavioral symptoms such as hyperactivity, an attention deficit and impulsiveness, deficient sustained attention and decreased monoamine functioning. Our experimental findings suggest that SHRs might be used as a relevant model of comorbidity between ADHD and epilepsy. Spontaneously hypertensive rats demonstrate abnormal electrophysiological and behavioral characteristics as well as monoamine deficit in the frontal cortex and the hippocampus, which are also evident in epileptic rats. In addition, SHRs shows higher seizure susceptibility in models of temporal lobe epilepsy and disturbed circadian rhythms. Taken together, experimental findings suggest that SHRs could be used to explore the mechanism underlying bi-directional link of ADHD and epilepsy and as a screening method for mechanism-driven therapeutic approaches.

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Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats

Cited by 15 publications

References 61 publications

Semi-Automated Biomarker Discovery from Pharmacodynamic Effects on EEG in ADHD Rodent Models

Semi-Automated Biomarker Discovery from Pharmacodynamic Effects on EEG in ADHD Rodent Models

Strain-dependent effects of long-term treatment with melatonin on kainic acid-induced status epilepticus, oxidative stress and the expression of heat shock proteins

Finding a model for comorbidity between attention deficit hyperactivity disorder and epilepsy

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