Cortical and cerebellar modulation of autonomic responses to loud sounds

Mueller‐Pfeiffer, Christoph; Zeffiro, Thomas A.; O’Gorman, Ruth L.; Michels, Lars; Baumann, Peter; Wood, N.; Spring, Justin D.; Rufer, Michael; Pitman, Roger K.; Orr, Scott P.

doi:10.1111/psyp.12142

Cited by 19 publications

(21 citation statements)

References 80 publications

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“…The lack of lateralization of responses might be explained by the facts that our stimulus was delivered binaurally and the task demands were restricted solely to the perception of an elementary sensation without any further cognitive processing. A salience effect, which would tend to be more right lateralized, would be unlikely with our study protocol (Mueller-Pfeiffer et al 2014 ).…”

Section: Discussionmentioning

confidence: 90%

Cortical Processing Related to Intensity of a Modulated Noise Stimulus—a Functional Near-Infrared Study

Weder

Zhou

Shoushtarian

et al. 2018

JARO

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Sound intensity is a key feature of auditory signals. A profound understanding of cortical processing of this feature is therefore highly desirable. This study investigates whether cortical functional near-infrared spectroscopy (fNIRS) signals reflect sound intensity changes and where on the brain cortex maximal intensity-dependent activations are located. The fNIRS technique is particularly suitable for this kind of hearing study, as it runs silently. Twenty-three normal hearing subjects were included and actively participated in a counterbalanced block design task. Four intensity levels of a modulated noise stimulus with long-term spectrum and modulation characteristics similar to speech were applied, evenly spaced from 15 to 90 dB SPL. Signals from auditory processing cortical fields were derived from a montage of 16 optodes on each side of the head. Results showed that fNIRS responses originating from auditory processing areas are highly dependent on sound intensity level: higher stimulation levels led to higher concentration changes. Caudal and rostral channels showed different waveform morphologies, reflecting specific cortical signal processing of the stimulus. Channels overlying the supramarginal and caudal superior temporal gyrus evoked a phasic response, whereas channels over Broca’s area showed a broad tonic pattern. This data set can serve as a foundation for future auditory fNIRS research to develop the technique as a hearing assessment tool in the normal hearing and hearing-impaired populations.

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Section: Discussionmentioning

confidence: 90%

Cortical Processing Related to Intensity of a Modulated Noise Stimulus—a Functional Near-Infrared Study

Weder

Zhou

Shoushtarian

et al. 2018

JARO

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“…The musical segments used in this study have been extensively evaluated and widely used to elicit emotions in laboratory studies (Kasos, Zimonyi, et al, 2018;Khalfa, Isabelle, Jean-Pierre, & Manon, 2002;Peretz, Gagnon, & Bouchard, 1998;Vieillard et al, 2008). Neutral tones of differing length, pitch, and intensity are also commonly used to study skin conductance orientation responses (Kasos, Zimonyi, et al, 2018;Kekecs, Szekely, & Varga, 2016;Mueller-pfeiffer et al, 2014;Weger, Meier, Robinson, & Inhoff, 2007;Zuckerman & Neary, 1976). The music used in experiment 2 (Online Appendix 2) was meticulously validated for the emotions induced and the persistence of the induced emotions (Ribeiro, Santos, Albuquerque, & Oliveira-Silva, 2019).…”

Section: Sources and Justification Of Stimuli Used In The Experimentsmentioning

confidence: 99%

Bilateral comparison of traditional and alternate electrodermal measurement sites

et al. 2020

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Advances in mobile and wireless technology have expanded the scope of electrodermal research. Since traditional electrodermal measurement sites are not always suitable for laboratory research and are rarely appropriate for ambulatory measurements, there is a need to explore and contrast alternate measurement locations. We evaluated bilateral electrodermal activity (EDA) from five measurement sites (fingers, feet, wrists, shoulders, and calves). In a counterbalanced, randomized, within‐subjects design study, participants (N = 115) engaged in a 4‐min‐long breathing exercise and were exposed to emotionally laden and neutral stimuli. High within‐subject correlations were found between the EDA measured from fingers bilaterally (r = .89), between the left fingers and both feet (r = .72). Moderate correlations were found between EDA measured from the left fingers and wrists (r = .30 and r = .33), low correlations between the left fingers and the shoulders (r = −.03 and r = −.06) or calves (r = .05 and r = .14). Response latency was the shortest on the fingers while it was the longest on the lower body. Short response windows would miss some of the responses from the palmar surfaces and a substantial number from other evaluated locations. The fingers and the feet are the most reliable locations to measure from, followed by the wrists. We suggest setting site‐specific response windows for different measurement locations. An investigation of repeatability showed that within‐subject correlations, response frequencies, response amplitudes show a similar pattern from the first measurement time to a later one.

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“…Perceptually similar sound sources can have very different biological implications (compare, for example, the rumble of thunder and the growl of a large predator). Auditory salience cues such as loudness, movement (looming) and affective valence are coded physiologically in pupillary and other autonomic responses ( Fletcher et al., 2015c , Fletcher et al., 2015d , Neuhoff, 2001 ) mediated by distributed cortico-subcortical brain networks ( Beissner et al., 2013 , Critchley et al., 2000 , Mueller-Pfeiffer et al., 2014 ). In addition to these well recognised examples, auditory semantic ambiguity is also a candidate salience cue: there is a biological imperative to resolve the identity of potentially meaningful sounds, and the ability to do this efficiently and accurately is likely to have conferred survival and reproductive advantages during human evolution.…”

Section: Introductionmentioning

confidence: 99%

A physiological signature of sound meaning in dementia

Fletcher

Nicholas

Downey

et al. 2016

Cortex

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The meaning of sensory objects is often behaviourally and biologically salient and decoding of semantic salience is potentially vulnerable in dementia. However, it remains unclear how sensory semantic processing is linked to physiological mechanisms for coding object salience and how that linkage is affected by neurodegenerative diseases. Here we addressed this issue using the paradigm of complex sounds. We used pupillometry to compare physiological responses to real versus synthetic nonverbal sounds in patients with canonical dementia syndromes (behavioural variant frontotemporal dementia – bvFTD, semantic dementia – SD; progressive nonfluent aphasia – PNFA; typical Alzheimer's disease – AD) relative to healthy older individuals. Nonverbal auditory semantic competence was assessed using a novel within-modality sound classification task and neuroanatomical associations of pupillary responses were assessed using voxel-based morphometry (VBM) of patients' brain MR images. After taking affective stimulus factors into account, patients with SD and AD showed significantly increased pupil responses to real versus synthetic sounds relative to healthy controls. The bvFTD, SD and AD groups had a nonverbal auditory semantic deficit relative to healthy controls and nonverbal auditory semantic performance was inversely correlated with the magnitude of the enhanced pupil response to real versus synthetic sounds across the patient cohort. A region of interest analysis demonstrated neuroanatomical associations of overall pupil reactivity and differential pupil reactivity to sound semantic content in superior colliculus and left anterior temporal cortex respectively. Our findings suggest that autonomic coding of auditory semantic ambiguity in the setting of a damaged semantic system may constitute a novel physiological signature of neurodegenerative diseases.

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Cortical and cerebellar modulation of autonomic responses to loud sounds

Abstract: P (2014). Cortical and cerebellar modulation of autonomic responses to loud sounds. Psychophysiology, 51(1):60-69.

Cited by 19 publications

References 80 publications

Cortical Processing Related to Intensity of a Modulated Noise Stimulus—a Functional Near-Infrared Study

Cortical Processing Related to Intensity of a Modulated Noise Stimulus—a Functional Near-Infrared Study

Bilateral comparison of traditional and alternate electrodermal measurement sites

A physiological signature of sound meaning in dementia

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