Cortical Activation in Profoundly Deaf Patients during Cochlear Implant Stimulation Demonstrated by H215O PET

Herzog, H; Lamprecht, A.; Kühn, Axel; Roden, W.; Vosteen, K. H.; Feinendegen, L. E.

doi:10.1097/00004728-199105000-00005

Cited by 48 publications

(27 citation statements)

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“…Some studies (34) found stronger activation in the contralateral size of the implant. In this study, in the GOOD group, 66% of patients were left-implanted and the main effect was also left-sided as in the control group.…”

Section: Tva and Brain Imagingmentioning

confidence: 98%

Cochlear Implant Benefits in Deafness Rehabilitation: PET Study of Temporal Voice Activations

Coëz¹,

Zilbovicius²,

Ferrary³

et al. 2007

J Nucl Med

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Cochlear implants may improve the medical and social prognosis of profound deafness. Nevertheless, some patients have experienced poor results without any clear explanations. One correlate may be an alteration in cortical voice processing. To test this hypothesis, we studied the activation of human temporal voice areas (TVA) using a well-standardized PET paradigm adapted from previous functional MRI (fMRI) studies. Methods: A PET H 2 15 O activation study was performed on 3 groups of adult volunteers: normal-hearing control subjects (n 5 6) and cochlearimplanted postlingually deaf patients with .2 y of cochlear implant experience, with intelligibility scores in the ''Lafon monosyllabic task'' .80% (GOOD group; n 5 6) or ,20% (POOR group; n 5 6). Relative cerebral blood flow was measured in 3 conditions: rest, passive listening to human voice, and nonvoice stimuli. Results: Compared with silence, the activations induced by nonvoice stimuli were bilaterally located in the superior temporal regions in all groups. However these activations were significantly and similarly reduced in both cochlear implant groups, whereas control subjects showed supplementary activations. Compared with nonvoice, the voice stimuli induced bilateral activation of the TVA along the superior temporal sulcus (STS) in both the control and the GOOD groups. In contrast, these activations were not detected in the POOR group, which showed only left unilateral middle STS activation. Conclusion: These results suggest that PET is an adequate method to explore cochlear implant benefits and that this benefit could be linked to the activation of the TVA.

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Section: Tva and Brain Imagingmentioning

confidence: 98%

Cochlear Implant Benefits in Deafness Rehabilitation: PET Study of Temporal Voice Activations

Coëz¹,

Zilbovicius²,

Ferrary³

et al. 2007

J Nucl Med

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“…Unless plastic reorganization occurred shortly after CI implantation in the animals observed in this study, this explanation based on anatomical connections is unlikely given our findings of bilateral activation from monaural acoustic stimulation. Because binaural integration begins early in the auditory pathway, starting in the cochlear nucleus and continuing at each subsequent processing stage (Grothe et al, 2010), it is not surprising that many neurons in both left and right auditory cortex respond to monaural acoustic stimulation. Several physiological studies have found monaural acoustic stimulation to be effective in activating ipsilateral auditory cortex neurons (Brugge and Merzenich, 1973;Cheung et al, 2009); however, no studies in nonhuman primates have specifically examined the proportion of A1 neurons responsive to monaural acoustic stimulation of each of the two ears.…”

Section: Asymmetric Activation Of Auditory Cortex By Unilateral CI Stmentioning

confidence: 99%

“…Several PET studies in CI users have shown dominant contralateral activation (Naito et al, 1995;Hirano et al, 1997), although one PET study in CI subjects early after implantation (Ͻ2 months) showed ipsilateral dominance of CI stimulation (Ito et al, 2004). There is evidence that in some users unilateral CI stimulation causes bilateral activation in auditory cortex (Herzog et al, 1991;Limb et al, 2010). A number of studies using PET (Fujiki et al, 1999;Giraud et al, 2001;Green et al, 2005;Mortensen et al, 2006) and auditory evoked potentials (Zhang et al, 2010;Sharma et al, 2011) suggest that the extent and strength of cortical activation are associated with CI performance.…”

Section: Asymmetric Activation Of Auditory Cortex By Unilateral CI Stmentioning

confidence: 99%

“…In recent years, there has been a rapidly increased interest in treating patients with single-sided deafness with a unilateral CI implant on the deaf ear (Tokita et al, 2014). Single-sided deafness occurs in ϳ0.5 per 1000 newborns (Watkin and Baldwin, 2012;Kral et al, 2013a), ϳ2-5 per 1000 children (Hassepass et al, 2013), and ϳ1 per 10,000 adults (Vincent et al, 2015). In the United States, ϳ60,000 people acquire singlesided deafness every year (Weaver, 2015).…”

Section: Asymmetric Activation Of Auditory Cortex By Unilateral CI Stmentioning

confidence: 99%

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Selective Neuronal Activation by Cochlear Implant Stimulation in Auditory Cortex of Awake Primate

Johnson¹,

Santina

Wang³

2016

J. Neurosci.

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Despite the success of cochlear implants (CIs) in human populations, most users perform poorly in noisy environments and music and tonal language perception. How CI devices engage the brain at the single neuron level has remained largely unknown, in particular in the primate brain. By comparing neuronal responses with acoustic and CI stimulation in marmoset monkeys unilaterally implanted with a CI electrode array, we discovered that CI stimulation was surprisingly ineffective at activating many neurons in auditory cortex, particularly in the hemisphere ipsilateral to the CI. Further analyses revealed that the CI-nonresponsive neurons were narrowly tuned to frequency and sound level when probed with acoustic stimuli; such neurons likely play a role in perceptual behaviors requiring fine frequency and level discrimination, tasks that CI users find especially challenging. These findings suggest potential deficits in central auditory processing of CI stimulation and provide important insights into factors responsible for poor CI user performance in a wide range of perceptual tasks.

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“…PET has been used to study auditory processing in control subjects and to assess patients with cochlear implants (4,5). It has also been used to study cochlear electrical stimulation in subjects with longterm sensorineural deprivation, demonstrating a predominantly unilateral activation of the primary auditory cortex (6).…”

mentioning

confidence: 99%

A method for the direct electrical stimulation of the auditory system in deaf subjects: A functional magnetic resonance imaging study

Alwatban

Ludman

Mason

et al. 2002

Magnetic Resonance Imaging

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Purpose: To develop a safe functional magnetic resonance imaging (fMRI) procedure for auditory assessment of deaf subjects. Materials and Methods:A gold-plated tungsten electrode has been developed which has zero magnetic susceptibility. Used with carbon leads and a carbon reference pad, it enables safe, distortion-free fMRI studies of deaf subjects following direct electrical stimulation of the acoustic nerve. Minor pickup of the radio frequency (RF) pulses by the electrode assembly is difficult to eliminate, and a SPARSE acquisition sequence is used to avoid any effects of unintentional auditory nerve stimulation. Results:The procedure is demonstrated in a deaf volunteer. Activation is observed in the contralateral but not the ipsilateral primary auditory cortex. This is in sharp contrast to studies of auditory processing in hearing subjects, but consistent with the small number of previous positron emission tomography (PET) and MR studies on adult deaf subjects. Conclusion:The fMRI procedure is able to demonstrate whether the auditory pathway is fully intact, and may provide a useful method for preoperative assessment of candidates for cochlear implantation.

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Cortical Activation in Profoundly Deaf Patients during Cochlear Implant Stimulation Demonstrated by H215O PET

Cited by 48 publications

References 0 publications

Cochlear Implant Benefits in Deafness Rehabilitation: PET Study of Temporal Voice Activations

Cochlear Implant Benefits in Deafness Rehabilitation: PET Study of Temporal Voice Activations

Selective Neuronal Activation by Cochlear Implant Stimulation in Auditory Cortex of Awake Primate

A method for the direct electrical stimulation of the auditory system in deaf subjects: A functional magnetic resonance imaging study

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