Cortical activation during delay discounting in abstinent methamphetamine dependent individuals

Hoffman, William F.; Schwartz, Daniel L.; Huckans, Marilyn; McFarland, Bentson H.; Meiri, Gal; Stevens, Alexander A.; Mitchell, Suzanne H.

doi:10.1007/s00213-008-1261-1

Cited by 184 publications

(196 citation statements)

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“…Although METH effects on a simple visual fMRI paradigm have not been previously reported to our knowledge, several studies of brain activation during cognitive paradigms in METH-dependent individuals have found a mixed pattern of activation, similar to that observed in MDMA users, when compared with control subjects during a facial affect matching task (Payer et al, 2008) and a delay discounting task (Monterosso et al, 2007;Hoffman et al, 2008).…”

Section: Relationship To Previous Findingssupporting

confidence: 51%

Human Ecstasy Use is Associated with Increased Cortical Excitability: An fMRI Study

Bauernfeind

Dietrich

Blackford

et al. 2011

Neuropsychopharmacol

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The serotonergic neurotoxin, 3,4-methylenedioxymethamphetamine (MDMA/Ecstasy), is a highly popular recreational drug. Human recreational MDMA users have neurocognitive and neuropsychiatric impairments, and human neuroimaging data are consistent with animal reports of serotonin neurotoxicity. However, functional neuroimaging studies have not found consistent effects of MDMA on brain neurophysiology in human users. Several lines of evidence suggest that studying MDMA effects in visual system might reveal the general cortical and subcortical neurophysiological consequences of MDMA use. We used 3 T functional magnetic resonance imaging during visual stimulation to compare visual system lateral geniculate nucleus ( There were no between-group differences in brain activation in any region, but the heaviest MDMA users showed a significantly greater spatial extent of activation than controls in BA 17 (p ¼ 0.031) and BA 18 (p ¼ 0.049). These results suggest that human recreational MDMA use may be associated with a long-lasting increase in cortical excitability, possibly through loss of serotonin input to cortical and subcortical regions. When considered in the context of previous results, cortical hyper-excitability may be a biomarker for MDMA-induced serotonin neurotoxicity.

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Section: Relationship To Previous Findingssupporting

confidence: 51%

Human Ecstasy Use is Associated with Increased Cortical Excitability: An fMRI Study

Bauernfeind

Dietrich

Blackford

et al. 2011

Neuropsychopharmacol

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show abstract

“…Thus, aberrant activation of the INS following the gambling test in METH-treated rats may reflect the response of the salience network to positive and negative RPEs in the test. Because signals related to value functions and reward prediction errors are observed in many different areas (38), many other brain areas are likely to be involved in the process of updating action value functions; consequently, impaired functions of various brain areas might contribute to more impulsive choices in METH-dependent individuals (39).…”

Section: Discussionmentioning

confidence: 99%

Insular neural system controls decision-making in healthy and methamphetamine-treated rats

Mizoguchi

Katahira

Inutsuka

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Patients suffering from neuropsychiatric disorders such as substance-related and addictive disorders exhibit altered decisionmaking patterns, which may be associated with their behavioral abnormalities. However, the neuronal mechanisms underlying such impairments are largely unknown. Using a gambling test, we demonstrated that methamphetamine (METH)-treated rats chose a highrisk/high-reward option more frequently and assigned higher value to high returns than control rats, suggestive of changes in decisionmaking choice strategy. Immunohistochemical analysis following the gambling test revealed aberrant activation of the insular cortex (INS) and nucleus accumbens in METH-treated animals. Pharmacological studies, together with in vivo microdialysis, showed that the insular neural system played a crucial role in decision-making. Moreover, manipulation of INS activation using designer receptor exclusively activated by designer drug technology resulted in alterations to decision-making. Our findings suggest that the INS is a critical region involved in decision-making and that insular neural dysfunction results in risk-taking behaviors associated with altered decision-making.decision-making | methamphetamine | insular cortex | DREADD | motivational value D ecision-making is a key activity of everyday life. Consequently, disturbances in the ability to make appropriate decisions or anticipate their possible consequences can result in massive social, medical, and financial problems. Decision-making depends on three temporally and partially functionally distinct sets of processes: (i) assessment and formation of preferences among possible options, (ii) selection and execution of an action, and (iii) experience or evaluation of the outcome (1). These processes are thought to require an extended neural network, mainly comprising glutamatergic, serotonergic, noradrenergic, and dopaminergic pathways in the frontostriatal and limbic loops, including the cingulate cortex, orbitofrontal cortex (OFC), insular cortex (INS), striatum (St), basal ganglia, and amygdala (2). Analysis of these processes helps to distinguish which aspects of decision-making are differentially affected in various neuropsychiatric disorders (1).Poor decision-making is a symptom of several neuropsychiatric diseases, such as depression, schizophrenia, Parkinson's disease, and drug dependence (1,(3)(4)(5). Pathological decision-making in neuropsychiatric disorders is associated with an inability to make profitable long-term decisions that incorporate expectations of future outcomes (6). Thus, pathological decision-making is recognized as a core problem in neuropsychiatric disorders, and a better understanding of the mechanisms underlying altered decisionmaking should provide insights that could lead to successful treatments for these diseases.A hallmark of addiction is continuous use of substances despite negative consequences or the absence of positive consequences (7). Addicts are less able to flexibly adapt their behavior to changes in reward contingenci...

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“…Two studies reported that METH users showed increased impulsivity as measured by a delay-discounting test and showed decreased activity in the cingulate and dorsolateral PFC (Monterosso et al, 2007;Hoffman et al, 2008). Decreased activation was also observed in the frontal and insular cortices of METH users in response to a Stroop task, although task performance was not consistently different from control subjects (Salo et al, 2009;Nestor et al, 2011).…”

Section: Action Of Substituted Amphetamines and Cathinonesmentioning

confidence: 99%

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

Korpi¹,

Hollander²,

Farooq

et al. 2015

Pharmacol Rev

124

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Cortical activation during delay discounting in abstinent methamphetamine dependent individuals

Cited by 184 publications

References 50 publications

Human Ecstasy Use is Associated with Increased Cortical Excitability: An fMRI Study

Human Ecstasy Use is Associated with Increased Cortical Excitability: An fMRI Study

Insular neural system controls decision-making in healthy and methamphetamine-treated rats

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

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