Cortical activation associated with the experience of auditory hallucinations and perception of human speech in schizophrenia: a PET correlation study

Copolov, David L.; Seal, Marc L.; Maruff, Paul; Ulusoy, Recep; Wong, Michael; Tochon-Danguy, Henri; Egan, Gary F.

doi:10.1016/s0925-4927(02)00121-x

Cited by 130 publications

(83 citation statements)

References 36 publications

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“…45,46 As no activation of regions implicated in memory processes was observed, this study does not support this model. However, previous studies reported involvement of the parahippocampal region, implicated in memory processes, prior to AVH.…”

Section: Discussioncontrasting

confidence: 89%

Auditory Hallucinations Elicit Similar Brain Activation in Psychotic and Nonpsychotic Individuals

Diederen

Daalman

Weijer

et al. 2011

Schizophrenia Bulletin

115

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While auditory verbal hallucinations (AVH) are most characteristic for schizophrenia, they also occur in nonpsychotic individuals in the absence of a psychiatric or neurological disorder and in the absence of substance abuse. At present, it is unclear if AVH in these nonpsychotic individuals constitute the same phenomenon as AVH in psychotic patients. Comparing brain activation during AVH between nonpsychotic and psychotic individuals could provide important clues regarding this question. 21 nonpsychotic subjects with AVH and 21 matched psychotic patients indicated the presence of AVH during 3T functional magnetic resonance imaging (fMRI) scanning. To identify common areas of activation during the experience of AVH in both groups, a conjunction analysis was performed. In addition, a 2-sample t-test was employed todiscover possible differencesin AVH-related activation between the groups. Several common areas of activation were observed for the psychotic and nonpsychotic subjects during the experience of AVH, consisting of the bilateral inferior frontal gyri, insula, superior temporal gyri, supramarginal gyri and postcentral gyri, left precentral gyrus, inferior parietal lobule, superior temporal pole, and right cerebellum. No significant differences in AVH-related brain activation were present between the groups. The presence of multiple common areas of AVH-related activation in psychotic and nonpsychotic individuals, in the absence of significant differences, implicates the involvement of the same cortical network in the experience of AVH in both groups.

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Section: Discussioncontrasting

confidence: 89%

Auditory Hallucinations Elicit Similar Brain Activation in Psychotic and Nonpsychotic Individuals

Diederen

Daalman

Weijer

et al. 2011

Schizophrenia Bulletin

115

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“…Strengthening the purported effect of DISC1 on brain volume and its association with positive symptoms we also observed a significant inverse correlation between superior frontal gray matter volume and severity of hallucinations among patients. In that regard our results are consistent with other studies documenting an association between severity of hallucinations and prefrontal cortical abnormalities as assessed via magnetoencephalography (Kawaguchi et al 2005) and in event related potential (Papageorgiou et al 2005), positron emission tomography (Copolov et al 2003) and functional magnetic resonance imaging (Lennox et al 2000) studies in patients with schizophrenia. Moreover, other studies indicate that the prefrontal cortex may be an important region for the development of hallucinations (Castner et al 2003) and that atypical antipsychotics that are linked with positive symptom improvement (Kane et al 1988) alter frontal dopaminergic activity (Ichikawa and Meltzer, 1999).…”

Section: And Healthy Volunteers (Du Boisgueheneuc Et Al 2006)supporting

confidence: 92%

DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia

Szeszko

Hodgkinson

Robinson

et al. 2008

Biological Psychology

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Background-DISC1 is considered a susceptibility gene for schizophrenia and schizoaffective disorder, but little is known regarding the potential mechanisms through which it may confer increased risk. Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology.

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“…The filters applied for spontaneous measurements corresponded to the statistically significant frequency bands determined in schizophrenic patients in previous investigations [4,20] . Previously, no anomalies were found for the frequency range [7][8][9][10] Hz in schizophrenic patients with florid psychotic symptoms (including hallucinations) [4,10] . Therefore, the respective filter was not applied in the present investigation.…”

Section: Magnetoencephalographymentioning

confidence: 99%

“…Recently, alterations of white matter fiber tracts were found in the left hemisphere in patients with auditory hallucinations [8] . In MEG studies, hallucinating participants demonstrated a network of different cortical activations, including bilateral auditory cortex, left limbic regions, and right medial and right prefrontal cortex [1,5,9,10] . Other recent functional neuroimaging studies have confirmed the pattern of distributed structural abnormalities specific to hallucinations [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Specific and Unspecific Auditory Hallucinations in Patients with Schizophrenia

Reulbach

Bleich²,

Maihöfner³

et al. 2007

Neuropsychobiology

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Background/Aims: Different neuroimaging techniques have indicated that auditory association and language cortices are active in patients with schizophrenia and auditory hallucinations. Auditory verbal hallucinations are thought to arise from a disorder of inner speech, but little is known about their origin. Methods: Spontaneous magnetoencephalographic (MEG) measurements were recorded with a 74-channel two-sensor system (BIOMAGNES II) in 16 patients with schizophrenia and 8 healthy subjects in frequency ranges from 2 to 6 and 12.5 to 30 Hz. Eight patients had auditory hallucinations during the MEG recordings. Results: The total group of patients with schizophrenia showed a statistically significant elevation of the number of dipoles and dipole density maxima in slow frequency ranges compared to healthy subjects (p <0.001). Significant dipole activities in the fast frequency range were only found during auditory hallucinations (p <0.001). Dipole localization was concentrated in frontal and temporal regions depending on different qualities of hallucinations. In patients with external imperative voices we found a parallel activation of the dorsolateral frontal and temporal cortex. Conclusion: We conclude that various auditory hallucinations in schizophrenia are induced by different neuronal activities and may be represented by different cortical regions.

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Cortical activation associated with the experience of auditory hallucinations and perception of human speech in schizophrenia: a PET correlation study

Cited by 130 publications

References 36 publications

Auditory Hallucinations Elicit Similar Brain Activation in Psychotic and Nonpsychotic Individuals

Auditory Hallucinations Elicit Similar Brain Activation in Psychotic and Nonpsychotic Individuals

DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia

Specific and Unspecific Auditory Hallucinations in Patients with Schizophrenia

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