Cortical actin and the plasma membrane: inextricably intertwined

Köster, D; Mayor, Satyajit

doi:10.1016/j.ceb.2016.02.021

Cited by 107 publications

(86 citation statements)

References 109 publications

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“…The cortical actin cytoskeleton is undoubtedly one of the most important factors influencing membrane organization 149 and mechanics 150 . The actin scaffold has been shown to determine molecular diffusion dynamics (e.g.…”

Section: Mechanisms Of Domain Regulationmentioning

confidence: 99%

The mystery of membrane organization: composition, regulation and roles of lipid rafts

Sezgin

Levental

Mayor

et al. 2017

Nat Rev Mol Cell Biol

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Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct subcompartments that differ in their biophysical properties and composition. A large body of research has focused on understanding the basis for this heterogeneity and its physiological relevance. The membrane raft hypothesis formalized a physicochemical principle for a subtype of such lateral membrane heterogeneity, wherein the preferential associations of cholesterol and saturated lipids drives the formation of relatively packed (ordered) membrane domains that selectively recruit certain lipids and proteins. Recent years have yielded new insights into this concept and its in vivo relevance, primarily owing to the development of biochemical and biophysical technologies.

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Section: Mechanisms Of Domain Regulationmentioning

confidence: 99%

The mystery of membrane organization: composition, regulation and roles of lipid rafts

Sezgin

Levental

Mayor

et al. 2017

Nat Rev Mol Cell Biol

Self Cite

1,568

1,700

View full text Add to dashboard Cite

show abstract

“…, 2015; Fujiwara et al. , 2016; Koster and Mayor, 2016; Koster et al. , 2016) and the formation of transient interactions (Eggeling et al.…”

Section: Introductionmentioning

confidence: 99%

Diffusion of lipids and GPI-anchored proteins in actin-free plasma membrane vesicles measured by STED-FCS

Schneider

Waithe

Clausen

et al. 2017

MBoC

116

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“…The cortical actin cytoskeleton consists of a dense network of actin filaments, crosslinked by myosin-II and other actin-binding proteins, that is intrinsically linked to the cytoplasmic face of the plasma membrane (Biro et al., 2013, Charras et al., 2006, Clark et al., 2013, Fritzsche et al., 2013, Koster and Mayor, 2016, Morone et al., 2006). The regulation of the density and organization of actin filaments in the cell cortex, as well as their myosin-II driven contraction, provides the cell with mechanical resilience (Bovellan et al., 2014, Clark et al., 2013, Fritzsche et al., 2013, Fritzsche et al., 2016, Gauthier et al., 2012, Salbreux et al., 2012, Tinevez et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6

et al. 2017

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SummaryRhoA-mediated regulation of myosin-II activity in the actin cortex controls the ability of cells to contract and bleb during a variety of cellular processes, including cell migration and division. Cell contraction and blebbing also frequently occur as part of the cytopathic effect seen during many different viral infections. We now demonstrate that the vaccinia virus protein F11, which localizes to the plasma membrane, is required for ROCK-mediated cell contraction from 2 hr post infection. Curiously, F11-induced cell contraction is dependent on RhoC and not RhoA signaling to ROCK. Moreover, RhoC-driven cell contraction depends on the upstream inhibition of RhoD signaling by F11. This inhibition prevents RhoD from regulating its downstream effector Pak6, alleviating the suppression of RhoC by the kinase. Our observations with vaccinia have now demonstrated that RhoD recruits Pak6 to the plasma membrane to antagonize RhoC signaling during cell contraction and blebbing.

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Cortical actin and the plasma membrane: inextricably intertwined

Cited by 107 publications

References 109 publications

The mystery of membrane organization: composition, regulation and roles of lipid rafts

The mystery of membrane organization: composition, regulation and roles of lipid rafts

Diffusion of lipids and GPI-anchored proteins in actin-free plasma membrane vesicles measured by STED-FCS

RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6

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