Cortical abnormalities in Parkinson’s disease patients and relationship to depression: A surface-based morphometry study

Huang, Peiyu; Lou, Yue; Xuan, Min; Gu, Quanquan; Guan, Xiaojun; Xu, Xiaojun; Song, Zhe; Luo, Wei; Zhang, Minming

doi:10.1016/j.pscychresns.2016.03.002

Cited by 40 publications

(27 citation statements)

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“…The disrupted anterior insula FC may therefore cause disturbances in these brain functions. Previously, we had demonstrated decreased gray matter area and disrupted white matter integrity in the same region (11,12), but no correlation was found between imaging findings and behavioral scores in both studies. Therefore, we had speculated that those structural deficits could be acting indirectly.…”

Section: Discussionmentioning

confidence: 57%

“…Our previous studies demonstrated that depressed PD patients had decreased gray matter area and disrupted white matter integrity in the insula (11,12). The insula is a part of the cerebral cortex located deep within the lateral sulcus, which is believed to be involved in a variety of brain functions (13) including perception, emotion, cognition, etc.…”

Section: Introductionmentioning

confidence: 99%

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Damaged Insula Network Contributes to Depression in Parkinson’s Disease

et al. 2020

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Background: Depression is common in patients with Parkinson's disease (PD). Our previous studies suggest that depressed PD patients have altered insula structures. It is, however, still unknown whether the altered structures cause disruption of insula functional networks, further contributing to depression in PD. Methods: In the present study, 17 depressed PD patients, 17 non-depressed PD patients, and 17 normal controls were enrolled. All subjects went through neurological and psychiatric clinical assessments. Resting-state functional magnetic resonance imaging and seed-based insula functional analyses were performed to examine the insula functional connectivity alterations in PD patients. Results: We found that compared with normal controls, PD patients exhibited significantly decreased insula functional connectivity widely across the whole brain. Compared with non-depressed PD patients, depressed patients showed further decreased functional connectivity in the middle frontal gyrus and inferior parietal lobe. Furthermore, connectivity between the left anterior insula and middle frontal gyrus was positively correlated with the cognitive scale score. Conclusion: These results suggest that insula networks were severely damaged in PD patients, and that the disrupted connection between the salience network and executive control network might contribute to depression in PD.

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Damaged Insula Network Contributes to Depression in Parkinson’s Disease

et al. 2020

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“…These nuclei located in the frontal lobe and temporal lobe were critically involved in emotional function, and our results indicated that EOPD patients had more widespread dysfunction in emotional processing circuits. Previous studies have identified that hypoactivation or hypometabolism of SFG was associated with fatigue and apathy (Li et al, 2017;Shen et al, 2018;Zhang et al, 2018), as well as that atrophy and dysfunction of MFG might result in depression (Ring et al, 1994;Huang et al, 2016;Chagas et al, 2017;Hanganu et al, 2017) in PD patients. Furthermore, dysfunction within the temporal lobe was also related to depressive symptom (Zeng et al, 2012;Koseki et al, 2013;Kim et al, 2016).…”

Section: Eopd With More Widespread Dysfunction In Emotional Processinmentioning

confidence: 99%

ALFF and ReHo Mapping Reveals Different Functional Patterns in Early- and Late-Onset Parkinson’s Disease

Yue

Jiang²,

Shen³

et al. 2020

Front. Neurosci.

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Heterogeneity between late-onset Parkinson's disease (LOPD) and early-onset Parkinson's disease (EOPD) is mainly reflected in the following aspects including genetics, disease progression, drug response, clinical manifestation, and neuropathological change. Although many studies have investigated these differences in relation to clinical significance, the functional processing circuits and underlying neural mechanisms have not been entirely understood. In this study, regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) maps were used to explore different spontaneous brain activity patterns in EOPD and LOPD patients. Abnormal synchronizations were found in the motor and emotional circuits of the EOPD group, as well as in the motor, emotional, and visual circuits of the LOPD group. EOPD patients showed functional activity change in the visual, emotional and motor circuits, and LOPD patients only showed increased functional activity in the emotional circuits. In summary, the desynchronization process in the LOPD group was relatively strengthened, and the brain areas with changed functional activity in the EOPD group were relatively widespread. The results might point out different impairments in the synchronization and functional activity for EOPD and LOPD patients.

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“…Mood disorders were also associated with cortical and subcortical changes in PD patients (Carriere et al, 2014;Huang et al, 2016). Surface-based morphometric analysis showed that depressed PD patients had significant cortical thickness in the orbitofrontal regions and insula compared to nondepressed PD patients (Huang et al, 2016), and apathy in PD patients was associated with atrophy of the left nucleus accumbens (Carriere et al, 2014).…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

“…Surface-based morphometric analysis showed that depressed PD patients had significant cortical thickness in the orbitofrontal regions and insula compared to nondepressed PD patients (Huang et al, 2016), and apathy in PD patients was associated with atrophy of the left nucleus accumbens (Carriere et al, 2014). PD patients who experienced visual hallucinations had significant loss of GM volume in the lingual gyrus and superior parietal lobe compared to healthy controls and PD patients without visual hallucinations (Ramírez-Ruiz et al, 2007).…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%