“…Stress fibers are disrupted in cells with podosomes and invadopodia, whereas FAs associate and assemble with stress fibers (Carragher and Frame, 2004;Gimona and Buccione, 2006;Schoenwaelder and Burridge, 1999). Furthermore, podosomes and invadopodia specifically contain cortactin, N-WASP and Tks5 (also known as Fish), all of which can serve as substrates for Src family kinases (Mizutani et al, 2002;Oser et al, 2009;Seals et al, 2005;Suetsugu et al, 2002). Cortactin and N-WASP are required for actin remodeling during invadopodium formation (Luxenburg et al, 2006b;Mizutani et al, 2002;Yamaguchi et al, 2005).…”