Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway

Zhang, Xiaojian; K, Liu; Zhang, Tao; Wang, Zhenlei; Qin, Xuan; Jing, Xiaoqian; Wu, Haoxuan; Ji, Xiaofan; He, Yonggang; Zhao, Ren

doi:10.18632/oncotarget.13652

Cited by 29 publications

(24 citation statements)

References 48 publications

(44 reference statements)

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“…36 Cortactin has been associated with tumor spreading and aggressive phenotypes, and suggested as a biomarker to predict metastasis. 37 In marked contrast to these data, cortactin expression was not found to correlate with nodal metastasis in our cohort of cSCC patients and showed no impact on survival. Nevertheless, our findings are in good agreement with those reported by Sato et al in Head and neck squamous cell carcinoma.…”

Section: Discussioncontrasting

confidence: 99%

“…Cortactin overexpression has been found in multiple cancers, including head and neck squamous cell carcinoma, oral squamous cell carcinoma lung squamous cell carcinoma, gliosarcoma, breast cancer, colorectal cancer, and melanoma . Cortactin has been associated with tumor spreading and aggressive phenotypes, and suggested as a biomarker to predict metastasis . In marked contrast to these data, cortactin expression was not found to correlate with nodal metastasis in our cohort of cSCC patients and showed no impact on survival.…”

Section: Discussioncontrasting

confidence: 94%

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Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma

et al. 2018

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Background Focal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous squamous cell carcinoma (cSCC). Objective To investigate the relationship of FAK and cortactin expression with the clinicopathologic features and the impact on the prognosis of cSCC patients. Methods FAK and cortactin expression was analyzed by immunohistochemistry on paraffin‐embedded tissue samples from 100 patients with cSCC, and correlated with the clinical data. Results FAK overexpression was a significant risk factor for nodal metastasis with crude and adjusted ratios (HRs) of 2.04, (95% CI [1.08‐3.86], [P = 0.029]) and 2.23 (95% CI [1.01‐4.91], [P = 0.047]), respectively. Cortactin expression was not a significant risk factor for nodal metastasis. Conclusion These findings demonstrate that FAK overexpression is an independent predictor of nodal metastasis that might be helpful for risk stratification and management of patients with cSCC.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 94%

Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma

et al. 2018

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“…CRC is ranked as the sixth most prevalent cancer and the fifth most common factor for cancer-related deaths with the higher incidence in males and urban regions in China (17). Apart from environmental and acquired risk factors in the tumorigenic effect, a variety of genetic alterations and uncontrolable regulation of signaling pathways can also lead to the disorder of cell cycle or unlimited proliferation of the intestinal mucosal epithelial cells to seriously affect their normal growth regulation, eventually resulting in the transformation of normal colonic epithelium to CRC (18,19). For example, activation of Notch signaling pathway can influence cellular activities, such as cell proliferation, anti-apoptosis, or cellular migration and invasion in CRC, which is of great value for the clinical development of target therapeutic drugs (20).…”

Section: Discussionmentioning

confidence: 99%

Effects of RUNX3 mediated Notch signaling pathway on biological characteristics of colorectal cancer cells

Meng

2017

International Journal of Oncology

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This study investigated the effects of runt-related transcription factor 3 (RUNX3) mediated Notch pathway on the biological behavior of colorectal cancer (CRC) SW260 cells. CRC tissues and para-carcinoma tissues were collected from 182 CRC patients who had undergone surgical treatment between January 2008 and December 2010. Immunohistochemical staining with streptavidin-peroxidase (SP) was used to detect RUNX3, Notch1 and Jagged 1 expression levels. CRC SW260 cells were divided into the following groups: Control group, si-NC group, si-RUNX3 group, DAPT group, si-RUNX3+DAPT group, and si-NC+DAPT group. Expression levels of RUNX3, and Notch signaling related genes were measured by real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) and western blotting in vitro. Besides, MTT, soft agar colony formation, Annexin V-FITC/PI double staining and Transwell were performed to analyze the effects of RUNX3 on cell growth and metastasis. Lower positive expression rate of RUNX3 and higher positive expression rate of Notch1 and Jagged 1 were observed in CRC tissues than those in normal adjacent tissues with a negative correlation, and the expression levels were associated with the differentiation degree, TNM staging, lymph node metastasis and tumor invasion depth (all P<0.05). RUNX3 expression was reduced in si-RUNX3 and si-RUNX3+DAPT group but the expression levels of Notch signaling related genes were markedly increased in si-RUNX3 group or decreased in DAPT and si-NC+DAPT group, as compared with those in the control group (all P<0.05). In addition, the proliferation, colony formation, migration and invasion abilities of SW260 cells were enhanced in si-RUNX3 group but were restricted in DAPT and si-NC+DAPT group, which was contrary to cell apoptosis (all P<0.05). RUNX3 contributes to attenuate the proliferation and metastasis of CRC cells, and promotes cell apoptosis through inhibition of Notch signaling pathway.

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“…Cortactin (CTTN) and Clusterin (CLU) are well established regulators of cancer metastasis and drug resistance [45–47] as well as are associated with the gene ontology biological process - negative regulation of apoptotic signaling pathway (GO:2001234). While CLU has a chaperone role, CTTN works as an actin cytoskeleton regulator downstream to Src kinase, another protein dis-regulated in different cancers [48].…”

Section: Resultsmentioning

confidence: 99%

Fast and robust method for drug response biomarker identification and sample stratification

Das¹,

Bhattacharya²

2019

Preprint

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With unprecedented progress of cancer research, the world is now prepared with versatile arsenal of drugs to combat cancer. However, response of an individual to any drug or combination treatment stands as a major challenge and hence there exists the sheer need for personalized medication. Identification of drug response biomarkers from a wholistic tumor microenvironment analysis would guide researchers to develop custom-tailored treatment regimen. In this study, a fast and robust method has been developed to identify drug response biomarkers from entire transcriptomics data analysis in a data-driven manner. The biomarkers which were identified by the method, were able to stratify patients between responders vs non-responders population. Furthermore, bayesian network (BN) analysis, done on the data, brought forth a mechanistic insight into the role of identified biomarkers in regulating drug efficacy. The importance of this work lies with the protocol that is time saving and requires less computation power, yet analyzes a whole system data and helps the researchers to take a step forward towards the development of personalized care in effective cancer treatment.

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Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway

Cited by 29 publications

References 48 publications

Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma

Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma

Effects of RUNX3 mediated Notch signaling pathway on biological characteristics of colorectal cancer cells

Fast and robust method for drug response biomarker identification and sample stratification

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