Cortactin is associated with perineural invasion in the deep invasive front area of laryngeal carcinomas

Ambrosio, Eliane Papa; Rosa, Francisco Dalla; Domingues, Maria Aparecida Custódio; Villacis, Rolando A R; Coudry, Renata de Almeida; Tagliarini, José Vicente; Soares, Fernando Augusto; Kowalski, Luiz Paulo; Rogatto, Sílvia Regina

doi:10.1016/j.humpath.2010.05.030

Cited by 16 publications

(13 citation statements)

References 37 publications

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“…Tumour areas with strong F‐actin and invadopodia protein expression would correspond with sites of dynamic actin remodelling whereas non‐expression represents a shift to quiescence . The prominence of WIP ( n = 77/87; 88.5%) over cortactin ( n = 73/87, 83.9%), N‐WASP ( n = 59/87; 67.8%) and Src kinase ( n = 0/87, 0%) implicates WIP as the bona fide invadopodial protein marker in ameloblastoma, whilst the observed cortactin overexpression (score ranked close to WIP) reaffirms its profound association with invasiveness of this odontogenic neoplasm and other cancer types . On the other hand, only two‐thirds of current cases were N‐WASP positive, suggesting its limited role, whereas the absence of Src kinase indicates a lack of involvement .…”

Section: Discussionmentioning

confidence: 99%

“…Initiation of new actin filament (F‐actin) and their subsequent assembly is a key step towards the formation of these cellular protrusions . Actin polymerization is mediated by regulatory proteins notably cortactin, N‐WASP, WIP and Src kinase which formed core proteins of invadopodia, and these are upregulated in cells with a migratory phenotype .…”

Section: Introductionmentioning

confidence: 99%

“…However, the role of other invadopodia proteins, namely N‐WASP, WIP and Src kinase in ameloblastoma remains unclarified. As dysregulation of these molecules has been implicated in the progression and invasion of cancers (), the aim of this study was to investigate for their presence in ameloblastoma and to evaluate their significance.…”

Section: Introductionmentioning

confidence: 99%

“…This cytokine is localized to the cell periphery and maintains lamellipodia at the leading edge of the cell (7,8). Cortactin deregulation is associated with increased invasion and metastases of breast, oesophageal, renal, head and neck cancers (9)(10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

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Invadopodia proteins, cortactin, N‐WASP and WIP differentially promote local invasiveness in ameloblastoma

Siar

Rahman

Tsujigiwa

et al. 2016

J Oral Pathology Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Invadopodia proteins, cortactin, N‐WASP and WIP differentially promote local invasiveness in ameloblastoma

Siar

Rahman

Tsujigiwa

et al. 2016

J Oral Pathology Medicine

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“…Despite similarities in homology, HS1 and cortactin exert different biological functions. Cortactin is widely expressed in all types of cell and/or tissue with the exception of hematopoietic cells, and is associated with a poorer clinical prognosis in patients with different types of cancer including hepatocellular carcinoma, laryngeal cancer, ovarian cancer, colon cancer and non-small cell lung cancer (7,(20)(21)(22)(23)(24)(25). However, to the best of our knowledge, there have been no studies investigating an association between HS1 expression and oncological outcome in solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Hematopoietic lineage cell‑specific protein 1 immunoreactivity indicates an increased risk of poor overall survival in patients with ovarian carcinoma

et al. 2018

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Hematopoietic lineage cell-specific protein 1 (HS1) is a 75-kDa intracellular protein that is expressed primarily in hematopoietic cells. Several previous studies have demonstrated the association between HS1 expression and a poor prognosis in hematopoietic malignancies; however, in solid tumors, no studies not been reported. The present study examined the distribution and expression of HS1 in human epithelial ovarian carcinoma (EOC) to determine its clinical significance. Paraffin sections were obtained from EOC tissues and immunostained with HS1 antibody, and then the staining intensities were evaluated. Overall survival (OS) was determined using the Kaplan-Meier estimator method, and multivariate analysis was performed using the Cox proportional hazards analysis. In total, 195 patients with EOC (median age, 56 years) were enrolled into the present study. HS1 immunoreactivity was categorized based on expression levels: Low (89/195; 45.6%) and high (106/195; 54.4%). Results demonstrated no association between expression level(s) and any clinicopathological parameter including age, International Federation of Gynecology and Obstetrics (FIGO) staging, type of chemotherapy or type of surgery received. The 5-year OS rates of patients who demonstrated low (n=89) and high (n=106) HS1 expression were 90.4 and 66.7%, respectively. The OS times for patients with high HS1 expression were significantly shorter compared with those for patients exhibiting low HS1 expression (P=0.0065). Results obtained from the multivariate analysis demonstrated that the FIGO stage and the amount of HS1 expressed were significant independent prognostic markers for poorer OS (hazard ratio, 3.539; 95% confidence interval, 1.221-12.811; P=0.0187). High HS1 expression levels may serve as a useful biomarker in patients with EOC who are likely to exhibit an unfavorable clinical outcome.

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The Role of ECM Remodeling, EMT, and Adhesion Molecules in Cancerous Neural Invasion: Changing Perspectives

Mukherjee

Wai

et al. 2022

Advanced Biology

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the nerve, is often used synonymously with the term PNI. It is important to differentiate between these two terms as the former can be determined using imaging techniques as it is apparent both clinically and radiologically whereas the latter is more of a histological diagnosis. [4,5] The presence of PNI in malignant neoplasms serves as a marker for poor clinical prognosis and higher mortality rate among patients. PNI is most commonly detected in the aggressive pancreatic, prostate, head and neck, colorectal and gastric cancers. [6] Importantly, in some of these cancers, PNI is the only method of metastasis and it can exist independently without vascular and lymphatic invasion. [2,7] In head and neck, the prevalence of PNI varies between 25-80% when compared to non-PNI cases, whereas in pancreatic cancer, 90% of patients exhibit PNI. [8,9] Furthermore, multiple population-based studies carried out over the years have reported no significant difference in the development of PNI based on age, gender, ethnicity/race or other demographic risk factors like smoking history. [10,11,12] Knowledge of the structure and composition of the nerve and its perineural niche is integral to understanding PNI. The peripheral nerves are primarily composed of Schwann cells, fibroblasts, blood vessels along with axon bundles. The Schwann cells are essential for the maintenance of the axons as well as for the production of myelin in the peripheral nervous system. [13] The innermost endoneurium is composed of the extracellular matrix (ECM), fibroblasts and collagen. It is a delicate layer of connective tissue which wraps around the axon and capillaries. The axons are supported and protected by endoneurial cells which are found in this layer. [14] The perineurium has one or more layers of flat epithelial-like cells which group the axons and endoneurium into fascicles. The presence of tight and adherens junctions (AJs) in the epithelial layer adds to the robustness of this layer thereby providing a permeable, but selective barrier between the surrounding axons and tissues. [15] And finally, the outermost epineurium consists of a dense connective tissue layer composed of elastin fibers and collagen which surround the entire nerve bundle. [16] Numerous blood vessels can also be found in this layer as they serve as the vascular supply to the nerve. Based on the structure of the nerve, Leibig et al. [17] combined past and present definitions and defined PNI as the presence of cancer cells along the nerves Perineural invasion (PNI) refers to the cancerous invasion of nerves. It provides an alternative route for metastatic invasion and can exist independently in the absence of lymphatic or vascular invasion.It is a prominent characteristic of specific aggressive malignancies where it correlates with poor prognosis. The clinical significance of PNI is widely recognized despite a lack of understanding of the molecular mechanisms underlying its pathogenesis. The interaction between the nerve and the cancer cells is the most pivotal PNI step which...

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Cortactin is associated with perineural invasion in the deep invasive front area of laryngeal carcinomas

Cited by 16 publications

References 37 publications

Invadopodia proteins, cortactin, N‐WASP and WIP differentially promote local invasiveness in ameloblastoma

Invadopodia proteins, cortactin, N‐WASP and WIP differentially promote local invasiveness in ameloblastoma

Hematopoietic lineage cell‑specific protein 1 immunoreactivity indicates an increased risk of poor overall survival in patients with ovarian carcinoma

The Role of ECM Remodeling, EMT, and Adhesion Molecules in Cancerous Neural Invasion: Changing Perspectives

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