Corrrigendum to “Enhanced selectivity and search speed for method development using one-segment-per-component optimization strategies” [J. Chromatogr. A 1358 (2014) 145–154]

Proof of Concept To Achieve Infinite Selectivity for the Chromatographic Separation of Therapeutic Proteins

“…Nevertheless, there are some intrinsic benefits in using more complex gradient programs to improve separation power. 11 Indeed, nonlinear (concave or convex) gradients, such as power function based nonlinear gradients, have been successfully applied for therapeutic protein separations in both RPLC and IEX modes. 12,13 By using such gradients, resolution could be substantially increased, while analysis time could be shortened.…”

“…14 Another interesting approach was suggested by Tyteca and co-workers, termed as one-segment-per-component or one-segment-pergroup-of-components. 11 The idea of this methodology is to adjust the slope of the gradient after the elution of each individual component of the sample. Applying this method resulted in 40% reduction of the analysis time compared to the best linear gradient.…”