Corrosive Ingestion in Adults

Ramasamy, Kovil; Gumaste, Vivek

doi:10.1097/00004836-200308000-00005

Cited by 251 publications

(210 citation statements)

References 28 publications

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“…Most of the patients took acetic acid to commit suicide, as a way of dealing with mental distress or a family confl ict. These results are comparable to other studies showing a high percentage of suicidal poisonings with corrosive substances (14,15). The abuse of acetic acid occurs among all age groups, but most often in patients who are in their most productive years (13).…”

Section: Dic-disseminated Intravascular Coagulationsupporting

confidence: 89%

Severe Renal Function Impairment in Adult Patients Acutely Poisoned with Concentrated Acetic Acid

Chibishev¹,

Šikole

Pereska³

et al. 2013

Archives of Industrial Hygiene and Toxicology

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Acetic acid is a widely used organic acid with corrosive properties that depend on its concentration. If acetic acid is ingested in concentrations above 30 % it may severely damage the upper gastrointestinal tract and cause intravascular haemolysis, which can result in severe kidney and liver disorders and disseminated intravascular coagulation. In this retrospective study, we analysed acetic acid ingestion data collected at the University Clinic for Toxicology of Skopje, Macedonia from 1 January 2002 to 31 December 2011. The analysis included systemic complications, kidney damage, and the outcomes in particular. Over the ten years, 84 patients were reported at the Clinic to have ingested highly concentrated acetic acid. Twenty-eight developed kidney disorders, while the remaining 56 had no complications. Fatal outcome was reported for 11 patients, seven of whom had systemic complications and four severe gastrointestinal complications.

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Section: Dic-disseminated Intravascular Coagulationsupporting

confidence: 89%

Severe Renal Function Impairment in Adult Patients Acutely Poisoned with Concentrated Acetic Acid

Chibishev¹,

Šikole

Pereska³

et al. 2013

Archives of Industrial Hygiene and Toxicology

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“…Like pill-induced esophagitis, corrosive or caustic esophageal injury does not result in a specific pattern of injury and must be correlated with ingestion history. 15 Acid injury produces coagulative necrosis of the mucosa that at low magnification can be reminiscent of the compact hyperorthokeratosis of epidermoid metaplasia. Alkaline agents typically result in liquefactive necrosis with fat and protein digestion.…”

Section: Discussionmentioning

confidence: 99%

Esophageal leukoplakia or epidermoid metaplasia: a clinicopathological study of 18 patients

et al. 2014

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Oral leukoplakia is a relatively common, painless disorder of the oral mucosa. It predominantly affects middleaged to elderly men and has a strong association with tobacco smoking and alcohol intake. Concomitant histological findings of hyperorthokeratosis and a well-developed granular cell layer, termed orthokeratotic dysplasia, are often associated with oral squamous cell carcinoma. In contrast, analogous lesions within the esophagus, termed esophageal epidermoid metaplasia, are rarely encountered and poorly described in the literature. To better characterize the clinicopathological features of this entity, we have collected 25 cases from 18 patients. Patients ranged in age from 37 to 81 years (mean, 61.5 years), with a slight female predominance (10/18, 56%). On presentation, a majority of patients complained of dysphagia (10/18, 56%). Past medical history was significant for tobacco smoking or long history of second-hand smoke in 11 (61%) patients and alcohol intake in 7 (39%) patients. Seventeen (94%) patients with esophageal epidermoid metaplasia were located within the middle-to-distal esophagus. Histologically, all cases were sharply demarcated and characterized by epithelial hyperplasia, a thickened basal layer, acanthotic midzone, a prominent granular cell layer, and superficial hyperorthokeratosis. Adjacent high-grade squamous dysplasia and/or squamous cell carcinoma were seen in 3 out of 18 (17%) patients. Follow-up information was available for 13 out of 18 (72%) patients and ranged from 2 to 8.3 years (mean, 2.3 years). Seven of the 13 (54%) patients had persistent disease; however, none of them developed squamous dysplasia or squamous cell carcinoma. In an effort to assess the incidence of esophageal epidermoid metaplasia, 198 consecutive esophageal biopsies were prospectively surveyed over a 6-month period at three academic institutions. No cases were identified within this time frame. In summary, esophageal epidermoid metaplasia is a rare condition affecting the middle-to-distal esophagus in middle-aged to elderly females. The occurrence of adjacent high-grade squamous dysplasia and/or squamous cell carcinoma warrants close follow-up.

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“…Some researches mentioned it's safe to repeat endoscopy up to 3 weeks after caustic injury in expert hands [13,14]. Although upper gastrointestinal series plays the role in clinical evaluation, it's not as precise as endoscopic examination.…”

Section: Introductionmentioning

confidence: 99%

The Role of Second-look Endoscopy in Severe Esophageal Caustic Injury

Puo-Hsien¹,

Seak²,

Chiu³

et al. 2017

J Gastrointest Dig Syst

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Severe caustic ingestion often leads to multiple complications and high mortality rate. Esophagogastroduodenoscopy is recommended during the first 24 hours for severity and extent evaluation, but it seems insufficient to guide further managements in severe caustic injury patients due to rapid progression and variable clinical conditions. Therefore, we tried to evaluate the safety and role of second-look endoscopy in these patients in 1-2 weeks later.We retrospectively collected severe esophageal caustic injury (grade 2b, 3a, 3b) adults with and without secondlook endoscopy in subacute stage (6 th -14 th days after caustic injury) in Linkou Change Gung Memorial Hospital during 2011/1-2014/11. They were divided in to once endoscopy group and second-look endoscopic group according to the patients with second-look endoscopy or not. They were further matched with the same cause of caustic injury, corrosive properties, injury grading, and then selected with Excel RAND function. There were 26 patients in both groups.The average timing of second-look endoscopy was 10.23 ± 3.166 (mean ± SD) days after caustic ingestion. The hospital stay was significantly shorter in the second-look endoscopy group (24.92 ± 17.50 days, 54.38 ± 43.73 days, P=0.002). However, the complication rate was not statistically significant between these two groups.In conclusion, second-look endoscopy is safe and might shorten the hospital stay. However, prospective, randomized and larger sample size studies are needed to support the finding.

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Corrosive Ingestion in Adults

Cited by 251 publications

References 28 publications

Severe Renal Function Impairment in Adult Patients Acutely Poisoned with Concentrated Acetic Acid

Severe Renal Function Impairment in Adult Patients Acutely Poisoned with Concentrated Acetic Acid

Esophageal leukoplakia or epidermoid metaplasia: a clinicopathological study of 18 patients

The Role of Second-look Endoscopy in Severe Esophageal Caustic Injury

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