Corrosion resistance of praseodymium-ion-implanted TiN coatings in blood and cytocompatibility with vascular endothelial cells

Zhang, Ming; Ma, Shengli; Xu, Ke; Chu, Paul K.

doi:10.1016/j.vacuum.2015.04.014

Cited by 17 publications

(5 citation statements)

References 67 publications

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“…In addition, the endothelial cells showed good spreading on the TinN coatings. The presence of Pr also reduced the hemolysis rate from values over 5% to a percentage below 3% [ 110 ].…”

Section: Biological Role Of Hap and Its Substitution Ionsmentioning

confidence: 99%

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Lama-Odría

Valle

Puiggalı́

2023

IJMS

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Lately, there has been an increasing demand for materials that could improve tissue regenerative therapies and provide antimicrobial effects. Similarly, there is a growing need to develop or modify biomaterials for the diagnosis and treatment of different pathologies. In this scenario, hydroxyapatite (HAp) appears as a bioceramic with extended functionalities. Nevertheless, there are certain disadvantages related to the mechanical properties and lack of antimicrobial capacity. To circumvent them, the doping of HAp with a variety of cationic ions is emerging as a good alterative due to the different biological roles of each ion. Among many elements, lanthanides are understudied despite their great potential in the biomedical field. For this reason, the present review focuses on the biological benefits of lanthanides and how their incorporation into HAp can alter its morphology and physical properties. A comprehensive section of the applications of lanthanides-substituted HAp nanoparticles (HAp NPs) is presented to unveil the potential biomedical uses of these systems. Finally, the need to study the tolerable and non-toxic percentages of substitution with these elements is highlighted.

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“…In addition, the endothelial cells showed good spreading on the TinN coatings. The presence of Pr also reduced the hemolysis rate from values over 5% to a percentage below 3% [ 110 ].…”

Section: Biological Role Of Hap and Its Substitution Ionsmentioning

confidence: 99%

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Lama-Odría

Valle

Puiggalı́

2023

IJMS

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“…Some authors think that in general Pr 3+ is probably more important as a sensitizer of other RE 3+ than for its own emission [15]. Furthermore, when Pr 3+ was implanted into TiN coatings, it effectively improved corrosion resistance and hemocompatibility of this biomedical implant [16]. In addition, praseodymium can act as a good antibacterial and mild antifungal agent [17].…”

Section: Introductionmentioning

confidence: 99%

Influence of Pr3+ and CO32− Ions Coupled Substitution on Structural, Optical and Antibacterial Properties of Fluorapatite Nanopowders Obtained by Precipitation

Milojkov

Sokić

Radosavljević-Mihajlović

et al. 2021

Metals

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Coupled substitution of fluorapatite (FAP) crystal lattice plays an important role in the engineering of optically active nanomaterials. Uniform fluorapatite nanopowders doped with praseodymium (Pr3+) and carbonate (CO32−) ions have been successfully synthesized by precipitation method under room temperature (25 °C). The structural, morphological, chemical and optical properties of monophase material were characterized by X-ray diffraction (XRD), Fourier Transform Infrared and Far Infrared Spectroscopy (FTIR and FIR, respectively), Scanning Electron Microscopy with Energy Dispersive Spectroscopy (SEM/EDS), Transmission Electron Microscopy (TEM) and Photoluminescence Spectroscopy (PL). Coupled substitution of FAP crystal lattice with Pr3+ and CO32− reduces the crystallite size with a constant c/a ratio of 1.72. FTIR study showed that synthesized nanopowders were AB-type CO32− substitution, and FIR study revealed new Pr–O vibrations. TEM analysis was found that synthesized nanopowders were composed of irregular spheres in the nanometer range. The fluorescence of FAP nanoparticles was in the violet-blue region of the visible part of the spectrum. When Pr3+ was doped in a lattice, the violet-blue emission becomes sharper due to reabsorption. MCR–ALS analyses of fluorescence spectra indicated the shift of the maximum to the blue color with the increase in the concentration of Pr3+ ions. Additionally, luminescent nanopowders demonstrated significant antibacterial activity against Escherichia coli. As the obtained nanoparticles showed a good absorption of ultraviolet A light and reabsorption of blue-green luminescence, they are suitable for further development of optically active nanomaterials for light filtering. Optically active PrCFAP nanopowders with antibacterial properties may be promising additives for the development of multifunctional cosmetic and health care products.

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“…Alloys of praseodymium with magnesium have shown to be biocompatible and bioabsorbable in implant studies performed on rabbits . Corrossion-resistant Pr-TiN coatings are reported to exhibit positive results on endothelial cell proliferation and blood compatibility . Other biological properties of praseodymium including its wound healing potential are less explored.…”

Section: Introductionmentioning

confidence: 99%

“…17 Corrossionresistant Pr-TiN coatings are reported to exhibit positive results on endothelial cell proliferation and blood compatibility. 18 Other biological properties of praseodymium including its wound healing potential are less explored. Cobalt, even though a heavy metal, has shown to have a pro-angiogenic effect 19 and is serving the body as a trace element and cofactors of several enzymes.…”

Section: ■ Introductionmentioning

confidence: 99%

Praseodymium–Cobaltite-Reinforced Collagen as Biomimetic Scaffolds for Angiogenesis and Stem Cell Differentiation for Cutaneous Wound Healing

Vijayan

Sreekumar

Singh

et al. 2019

ACS Appl. Bio Mater.

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The present study describes the fabrication of collagen reinforced with praseodymium−cobaltite nanoparticles for wound healing applications. Praseodymium−cobaltite nanoparticles (PCNP) reinforced with collagen resulted in an increased thermal stability and decreased proteolytic susceptibility to collagen. Circular dichroism spectroscopy and ATR-FTIR (attenuated total reflection Fourier transform infrared) spectroscopy analyses confirm the intact structural integrity of the collagen sheets after cross-linking with praseodymium−cobaltite nanoparticles. Cross-linked collagen has shown to possess biocompatibility, less protein adsorption behavior, and hemocompatibility, which are the desirable properties of a wound dressing material. The nanoparticle cross-linked collagen sheets provided a proper matrix elasticity that promotes mesenchymal stem cell attachment and angiogenesis. Further, the scaffold promoted tube formation in endothelial cells. The enhancement of angiogenesis is considered to be brought about by the therapeutic potential of nanoparticle formulation. Praseodymium− cobaltite nanoparticle cross-linking increased the ductility of collagen sheets for the pro-angiogenic and stem cell differentiation ability. Also, the praseodymium−cobaltite cross-linked collagen sheets have been shown to induce a mild level of ROS (reactive oxygen species) generation in the DCFH-DA (2′,7′-dichlorodihydrofluorescein diacetate) assay, which is beneficial for angiogenesis as well as wound healing. This study paves the way for exploring the therapeutic potential of rare-earth-based nanoparticles for tissue engineering applications as an alternative for traditional wound healing materials.

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Corrosion resistance of praseodymium-ion-implanted TiN coatings in blood and cytocompatibility with vascular endothelial cells

Cited by 17 publications

References 67 publications

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Influence of Pr3+ and CO32− Ions Coupled Substitution on Structural, Optical and Antibacterial Properties of Fluorapatite Nanopowders Obtained by Precipitation

Praseodymium–Cobaltite-Reinforced Collagen as Biomimetic Scaffolds for Angiogenesis and Stem Cell Differentiation for Cutaneous Wound Healing

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