Corrosion resistance, antibacterial activity and drug release of ciprofloxacin-loaded micro-arc oxidation/silane coating on magnesium alloy AZ31

Xue, Kui; Liang, Lu-Xian; Cheng, Shen-Cong; Liu, Han-Peng; Cui, Lan-Yue; Zeng, Rong‐Chang; Li, Shuoqi; Wang, Zhenlin

doi:10.1016/j.porgcoat.2021.106357

Cited by 20 publications

(7 citation statements)

References 73 publications

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“… Summary of corrosion resistance, antibacterial activity and cytotoxicity of Mg-based bone implants [ 23 , 35 , 36 , 72 , 73 , 74 , 75 , 76 , 77 ]. …”

Section: Figurementioning

confidence: 99%

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In Vitro Degradation and Photoactivated Antibacterial Activity of a Hemin-CaP Microsphere-Loaded Coating on Pure Magnesium

Long

Song

Tian

et al. 2022

JFB

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Photoactivated sterilization has received more attention in dealing with implant-associated infections due to its advantages of rapid and effective bacteriostasis and broad-spectrum antibacterial activity. Herein, a micro-arc oxidation (MAO)/polymethyltrimethoxysilane (PMTMS)@hemin-induced calcium-bearing phosphate microsphere (Hemin-CaP) coating was prepared on pure magnesium (Mg) via MAO processing and dipping treatments. The morphology and composition of the coating were characterized via scanning electron microscopy, Fourier transform infrared spectrometer, X-ray diffractometer and X-ray photoelectron spectrometer. Corrosion behavior was evaluated through electrochemical and hydrogen evolution tests. The release of Fe3+ ions at different immersion times was measured with an atomic absorption spectrophotometer. Antibacterial performance and cytotoxicity were assessed using the spread plate method, MTT assay and live/dead staining experiment. The results showed that the corrosion current density of the MAO/PMTMS@(Hemin-CaP) coating (4.41 × 10−8 A·cm−2) was decreased by two orders of magnitude compared to that of pure Mg (3.12 × 10−6 A·cm−2). Photoactivated antibacterial efficiencies of the Hemin-CaP microspheres and MAO/PMTMS@(Hemin-CaP) coating reached about 99% and 92%, respectively, which we attributed to the photothermal and photodynamic properties of hemin with a porphyrin ring. Moreover, based on the release of Fe3+ ions, the MC3T3-E1 pre-osteoblasts’ viability reached up to 125% after a 72 h culture, indicating a positive effect of the coating in promoting cell growth. Thus, this novel composite coating holds a promising application as bone implants.

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“… Summary of corrosion resistance, antibacterial activity and cytotoxicity of Mg-based bone implants [ 23 , 35 , 36 , 72 , 73 , 74 , 75 , 76 , 77 ]. …”

Section: Figurementioning

confidence: 99%

“…The hydrolyzed silane condensed with the hydroxyl groups of the MAO coating sealed its porous structures effectively and enhanced its corrosion resistance. In addition, loading drugs [ 23 ] or nanoparticles [ 24 ] with the PMTMS has also been proved to be feasible.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Degradation and Photoactivated Antibacterial Activity of a Hemin-CaP Microsphere-Loaded Coating on Pure Magnesium

Long

Song

Tian

et al. 2022

JFB

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“…More recently, researchers are starting to create a path for multifunctional coatings that could extend the use of this type of alloy in challenging environments [118,119,130]. One such method was developed to create a multilayer with both organic and inorganic components, through plasma-induced thermal-field-assisted crosslinking deposition (PTCD).…”

Section: New Challenges In Coatings On Biodegradable Mg Alloysmentioning

confidence: 99%

Sustainable Coatings on Metallic Alloys as a Nowadays Challenge

2021

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Starting with a description of the meaning of sustainable coating nowadays, this review presents a selection of methods for sustainable coatings manufacture using raw materials, saving energy and costs. This selection creates an introduction for the coatings performances of intensively investigated coated alloys and their multifunctionality. There are many examples and EU recommendations to be discussed, and we especially chose to introduce sustainable coatings with both industrial and medical functions, such as bioinspired films and coatings on high-entropy alloys, biodegradable metallic alloys, etc. A special focus is on nanotechnology and nanomaterials in green procedures, enhancing coatings’ multifunctionality, introducing green corrosion inhibitors, smart additives, and coatings based on superhydrophobicity. The conclusions and future perspectives of sustainable and multifunctional coatings, as expressions of sustainable advanced materials, are based on important motivations of such studies.

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“…Silane has been investigated considerably for surface protection of magnesium alloys, as a component of composite coatings [28][29][30], and as a pretreatment for polymeric coatings [31]. For standalone silane coatings on magnesium alloys, pretreatments such as plasma electrolytic oxidation has been investigated for enhancing adhesion of silane with the alloy substrates [32][33][34]. In application of silanes as coatings on metallic surfaces, silane molecules form chemical bonds with the metal (M) substrate by condensation of silanol groups of hydrolysed silane molecules.…”

Section: Organo-silane Coatings For Improvement In Corrosion Resistancementioning

confidence: 99%

Role of Surface Preparation in Corrosion Resistance Due to Silane Coatings on a Magnesium Alloy

Saxena

Singh

2021

Molecules

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Coating of an organo-silane (Bis-1,2-(TriethoxySilyl)Ethane (BTSE)) has been observed to improve the corrosion resistance of magnesium alloy AZ91D. Three different types of surface preparations have been employed before condensing the silane coating on to the substrate. Corrosion resistance was investigated using electrochemical impedance spectroscopy (EIS). A specific alkali treatment of the substrate prior to the coating has been found to improve the corrosion resistance of the coated alloy, which has been attributed to the ability of the treatment in facilitating the condensation of a relatively compact siloxane film.

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Corrosion resistance, antibacterial activity and drug release of ciprofloxacin-loaded micro-arc oxidation/silane coating on magnesium alloy AZ31

Cited by 20 publications

References 73 publications

In Vitro Degradation and Photoactivated Antibacterial Activity of a Hemin-CaP Microsphere-Loaded Coating on Pure Magnesium

In Vitro Degradation and Photoactivated Antibacterial Activity of a Hemin-CaP Microsphere-Loaded Coating on Pure Magnesium

Sustainable Coatings on Metallic Alloys as a Nowadays Challenge

Role of Surface Preparation in Corrosion Resistance Due to Silane Coatings on a Magnesium Alloy

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