Corroles that bind with high affinity to both apo and holo transferrin

Coordination chemistry of corroles with focus on main group elements

“…Corrole 11 and its gallium(III) (11-Ga) and manganese(III) complexes were also determined to spontaneously bind transferrin (Tf) in both its iron-free apo form (apoTf) and the iron-bound holo form (holoTf) [70]. Transferrin is an excellent candidate for specific targeting of molecules of interest to cancer cells and to the brain, thus the corrole-transferrin conjugates might be utilized for targeting these corroles to cells that express the transferrin receptor.…”

“…That investigation revealed that cell entry is protein-mediated and correlated with the affinity for association of the corrole with different protein. For instance, although the dissociation constants of 11-Ga from its spontaneously formed bioconjugate with apo-and holo-transferrin are in the range of 10 −7 to 10 −8 M, human serum albumin can still outcompete the corrole from transferrin conjugates [70]. The association of 11-Ga with a specifically designed breast cancer delivery protein is however even stronger.…”

Investigation on the interaction between tamoxifen and human holo-transferrin: Determination of the binding mechanism by fluorescence quenching, resonance light scattering and circular dichroism methods

“…This is the first attempt made to study the mode of interaction of TMX with HTF. Among techniques commonly used to detect interactions between drugs and HTF can be mentioned fluorescence spectroscopy [22][23][24], UV-spectrophotometry [25][26][27], circular dichroism (CD) [28], attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy [29], EPR spectroscopy [30] and differential scanning calorimetry [31].…”

Synthesis of amphiphilic sulfonamide halogenated porphyrins: MALDI-TOFMS characterization and evaluation of 1-octanol/water partition coefficients

“…12,[23][24][25][26][27][28] Metallocomplexes of amphiphilic sulfonamide porphyrins proved to be quite good catalysts for epoxidation of alkenes 29 and oxidation of azo dyes in biphasic systems using hydrogen peroxide as oxidant. 30 Furthermore, the synthesis of amphiphilic corroles with sulfonic acid head groups and their multiple applications on bio-mimetic catalysis, 31,32 bio-medicine 33,34 and photovoltaic cells 35 have been recently described by Gross.…”