Corrigendum: YAP and TAZ Regulate Cc2d1b and Purβ in Schwann Cells

Belin, Sophie; Herron, Jacob; VerPlank, Jordan J. S.; Park, Yungki; Feltri, L; Poitelon, Yannick

doi:10.3389/fnmol.2019.00256

Cited by 7 publications

(13 citation statements)

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“…Contralateral and crush sciatic nerves were dissected, and the segment distal to the crush site was use for further analysis. Sciatic nerves were then frozen in liquid nitrogen, pulverized and resuspended in lysis buffer (150 mm NaCl, 25 mm HEPES, 0.3% CHAPS, pH 7.4, 1 mm Na3VO4, 1 mm NaF and 1:100 Protease Inhibitor Cocktail [Roche Diagnostic, Florham Park, NJ]) (Belin, Herron, et al, 2019; Belin, Ornaghi, et al, 2019). Protein lysates were centrifuged at 15,000 g for 30 min at 4°C.…”

Section: Methodsmentioning

confidence: 99%

“…Contralateral and crush sciatic nerves were dissected, and the segment distal to the crush site was use for further analysis. Sciatic nerves were dissected, stripped of epineurium, frozen in liquid nitrogen, pulverized and processed as described (Belin et al, 2019 b). Total RNA was prepared from sciatic nerve or SCs with TRIzol (Roche Diagnostic).…”

Section: Methodsmentioning

confidence: 99%

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YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration

Jeanette

Marziali

Bhatia

et al. 2020

Glia

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YAP and TAZ are effectors of the Hippo pathway that controls multicellular development by integrating chemical and mechanical signals. Peripheral nervous system development depends on the Hippo pathway. We previously showed that loss of YAP and TAZ impairs the development of peripheral nerve as well as Schwann cell myelination. The role of the Hippo pathway in peripheral nerve regeneration has just started to be explored. After injury, Schwann cells adopt new identities to promote regeneration by converting to a repair‐promoting phenotype. While the reprogramming of Schwann cells to repair cells has been well characterized, the maintenance of such repair phenotype cannot be sustained for a very long period, which limits nerve repair in human. First, we show that short or long‐term myelin maintenance is not affected by defect in YAP and TAZ expression. Using crush nerve injury and conditional mutagenesis in mice, we also show that YAP and TAZ are regulators of repair Schwann cell proliferation and differentiation. We found that YAP and TAZ are required in repair Schwann cells for their redifferentiation into myelinating Schwann cell following crush injury. In this present study, we describe how the Hippo pathway and YAP and TAZ regulate remyelination over time during peripheral nerve regeneration.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration

Jeanette

Marziali

Bhatia

et al. 2020

Glia

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“…However, YAP/TAZ are functionally redundant, as deletion of one of two YAP alleles in the context of TAZ deletion aggravates the radial sorting phenotype. 92,127,128 As for other cell types and as introduced in part 1 in this review, 28,92,127,128,133,134,200 However, the absence of NF2 causes transient hypomyelination, but whether this is due to the lack of Hippo-mediated repression of YAP/TAZ is unknown. 135 In addition, deletion of TEAD4 downstream of HDAC3 causes remarkable hypermyelination in mice, increases PI3K and ERK signaling and promotes upregulation of myelin-related genes, 136 suggesting that TEAD1 and TEAD4 may have opposite functions in myelination.…”

Section: Dorsal Root Ganglia Neurons and Satellite Cellsmentioning

confidence: 99%

The Hippo pathway: Horizons for innovative treatments of peripheral nerve diseases

Feltri

Weaver

Belin

et al. 2021

J Peripheral Nervous Sys

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Initially identified in Drosophila, the Hippo signaling pathway regulates how cells respond to their environment by controlling proliferation, migration and differentiation. Many recent studies have focused on characterizing Hippo pathway function and regulation in mammalian cells. Here, we present a brief overview of the major components of the Hippo pathway, as well as their regulation and function. We comprehensively review the studies that have contributed to our understanding of the Hippo pathway in the function of the peripheral nervous system and in peripheral nerve diseases. Finally, we discuss innovative approaches that aim to modulate Hippo pathway components in diseases of the peripheral nervous system.

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“…In addition, CC2D1A and CC2D1B have been reported to regulate gene transcription, as they both can bind a dual repressor element in the HTR1A promoter and repress the expression of serotonin 1A receptor in neurons (Hadjighassem et al, 2009 , 2011 ). However, while Cc2d1a is highly expressed in neurons and has been implicated in intellectual disability and autism spectrum disorder (Basel-Vanagaite et al, 2006 ; Manzini et al, 2014 ), Cc2d1b has been associated with myelin formation (Belin et al, 2019 ). We and others have previously shown that Cc2d1b is expressed in mouse sciatic nerves and more specifically in myelinating and non-myelinating Schwann cells (Belin et al, 2019 ; Gerber et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, while Cc2d1a is highly expressed in neurons and has been implicated in intellectual disability and autism spectrum disorder (Basel-Vanagaite et al, 2006 ; Manzini et al, 2014 ), Cc2d1b has been associated with myelin formation (Belin et al, 2019 ). We and others have previously shown that Cc2d1b is expressed in mouse sciatic nerves and more specifically in myelinating and non-myelinating Schwann cells (Belin et al, 2019 ; Gerber et al, 2021 ). In addition, Schwann cell-knockdown of Cc2d1b in Schwann cell-neuron cocultures impairs myelination in vitro independently of effects on Schwann cell number, proliferation, or apoptosis (Belin et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Cc2d1b Contributes to the Regulation of Developmental Myelination in the Central Nervous System

Acheta

Hong

Jeanette

et al. 2022

Front. Mol. Neurosci.

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BackgroundNumerous studies have indicated that myelination is the result of the interplay between extracellular signals and an intricate network of transcription factors. Yet, the identification and characterization of the full repertoire of transcription factors that modulate myelination are still incomplete. CC2D1B is a member of the Lgd/CC2D1 family of proteins highly expressed in myelinating cells in the central and peripheral nervous systems. In addition, the absence of CC2D1B limits myelin formation in vitro. Here we propose to delineate the function of CC2D1B in myelinating cells during developmental myelination in vivo in the central and peripheral nervous systems.MethodsWe used a Cc2d1b constitutive knockout mouse model and then performed morphological analyses on semithin sections of sciatic nerves and electron micrographs of optic nerves. We also performed immunohistological studies on coronal brain sections. All analyses were performed at 30 days of age.ResultsIn the peripheral nervous system, animals ablated for Cc2d1b did not show any myelin thickness difference compared to control animals. In the central nervous system, immunohistological studies did not show any difference in the number of oligodendrocytes or the level of myelin proteins in the cortex, corpus callosum, and striatum. However, optic nerves showed a hypomyelination (0.844 ± 0.022) compared to control animals (0.832 ± 0.016) of large diameter myelinated fibers.ConclusionsWe found that CC2D1B plays a role in developmental myelination in the central nervous system. These results suggest that CC2D1B could contribute to gene regulation during oligodendrocytes myelination in optic nerves.

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Corrigendum: YAP and TAZ Regulate Cc2d1b and Purβ in Schwann Cells

Cited by 7 publications

References 0 publications

YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration

YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration

The Hippo pathway: Horizons for innovative treatments of peripheral nerve diseases

Cc2d1b Contributes to the Regulation of Developmental Myelination in the Central Nervous System

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