Corrigendum: Transplanted Erythropoietin-Expressing Mesenchymal Stem Cells Promote Pro-survival Gene Expression and Protect Photoreceptors From Sodium Iodate-Induced Cytotoxicity in a Retinal Degeneration Model

Koh, Avin Ee-Hwan; Alsaeedi, Hiba Amer; Rashid, Munirah Binti Abd; Lam, Chenshen; Harun, Mohd Hairul Nizam; Ng, Min Hwei; Isa, Hazlita Mohd; Then, K.; Bastion, Mae-Lynn Catherine; Farhana, Aisha; Alam, Mohammad Khursheed; Subbiah, Suresh Kumar; Mok, Pooi Ling

doi:10.3389/fcell.2021.764504

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In all parameters, BDNF-MSCs induced better results than non-modified MSCs, suggesting that genetic engineering improved the therapeutic efficacy of the MSCs (Lejkowska et al, 2019 ). Intravitreal injection of erythropoietin-expressing MSCs also increased photoreceptor neuroprotection in a model of sodium iodate-induced retinal degeneration, as shown by electroretinography (Koh et al, 2021 ). Neuroinflammation is another key aspect of several neurodegenerative conditions.…”

Section: Msc Modificationsmentioning

confidence: 98%

Current Status of Mesenchymal Stem/Stromal Cells for Treatment of Neurological Diseases

Soares

Gonçalves

Vasques

et al. 2022

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Neurological disorders include a wide spectrum of clinical conditions affecting the central and peripheral nervous systems. For these conditions, which affect hundreds of millions of people worldwide, generally limited or no treatments are available, and cell-based therapies have been intensively investigated in preclinical and clinical studies. Among the available cell types, mesenchymal stem/stromal cells (MSCs) have been widely studied but as yet no cell-based treatment exists for neurological disease. We review current knowledge of the therapeutic potential of MSC-based therapies for neurological diseases, as well as possible mechanisms of action that may be explored to hasten the development of new and effective treatments. We also discuss the challenges for culture conditions, quality control, and the development of potency tests, aiming to generate more efficient cell therapy products for neurological disorders.

show abstract

Section: Msc Modificationsmentioning

confidence: 98%