Corrigendum to ‘Trends and recent development of the microelectrode arrays (MEAs)’ [Biosens. Bioelectr., 175: 112854]

Xu, Longqian; Hu, Chin-Hwa; Huang, Qi; Jin, Kai; Zhao, Ping; Wang, Dongping; Hou, Wei; Dong, Lihua; Hu, Siyi; Ma, Hanbin

doi:10.1016/j.bios.2021.113047

Cited by 6 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Electrical cell-substrate impedance sensing Among the electrical sensors that invasively contact the cell culture environment, the micro-scale working volume on the electrode array chip for cell monitoring has been typical from the birth of the microelectrode array (MEA) chip. [17][18][19]34,[58][59][60][61] However, the most common approaches toward the cell-to-culture ware interface impedimetric sensing target involve cell contact or motile ability. [47,62,63] One example is Rapier et al reported a simple and intrinsic microfluidic sensory system based on impedimetric sensing for determining cell location and confluency.…”

Section: Electrical Sensormentioning

confidence: 99%

Advances in sensor developments for cell culture monitoring

Kim,

Yeo

2023

BMEMat

View full text Add to dashboard Cite

Cell culture encompasses procedures for extracting cells from their natural tissue and cultivating them under controlled artificial conditions. During this process, various factors, including cell physiological/morphological properties, culture environments, metabolites, and contaminants, have to be precisely controlled and monitored for the survival of cells and the pursuit of the desired properties of the cells. This review summarizes recent advances in sensor technologies and manufacturing strategies for various cell culture platforms using traditional plastics, microfluidic chips, and scalable bioreactors. We share the details of newly developed biological sensors, chemical sensors, optical sensors, electronic chip technologies, and material integration methods. The precise control of parameters based on the feedback by these sensors and electronics enhances cell culture quality and throughput.

show abstract

Section: Electrical Sensormentioning

confidence: 99%

Advances in sensor developments for cell culture monitoring

Kim,

Yeo

2023

BMEMat

View full text Add to dashboard Cite

show abstract

“…More in detail, MEAs are common bioelectronics platforms engineered to connect an electronic circuitry with different cell types to captures the field potential or activity across an entire population of cells, by measuring biological signals at multiple points, thus detecting activity patterns that would otherwise elude traditional assays. [186][187][188] Hence, the miniaturized electrodes, featuring multiple plates or shanks, enhance the tissue-electronic circuit interaction allowing recording by transducing ionically mediated voltage changes in the biological environment into electronic currents [189,190] but also stimulation by reversing the transduction direction. [191,192] In this context, even though conventional electronics materials have been widely employed, CPs have been introduced as coatings to decrease the electrodes impedance enhancing the electrode-tissue interaction and electrical properties of conventional metal-or semiconductor-based bioelectric signal transducers.…”

Section: Organic Platforms: the Vehicles To Reach The Destinationmentioning

confidence: 99%

Conductive Polymer‐Based Bioelectronic Platforms toward Sustainable and Biointegrated Devices: A Journey from Skin to Brain across Human Body Interfaces

Bettucci

Matrone

Santoro

2021

Adv Materials Technologies

View full text Add to dashboard Cite

the human's body toward medical applications. [1] Coupling electronics with human tissues allows sensing, stimulating and possibly regulating biological functions. On these premises, a key paradigm of bioelectronics is to preserve the functionality of the biological environment upon coupling, in order to "observe biology through non-perturbing lenses". However, aiming to a seamless interface, the properties of common electronic components, based on metals or inorganic semiconductors, have major limitations to comply with the coupling requirements for cells, organs, and tissues. [2] In fact, inorganic materials might display mechanical rigidity (high Young's modulus ≈100 GPa), [3,4] surface degradation phenomena (oxidation) [5] and surface structure which increases interface capacitance. [6,7] Organic materials have so emerged combining mechanical flexibility, compatibility with large area and different surface functionalization processes, while keeping high electrical conductivity and reproducibility. [8,9] Particularly, these materials intrinsically display key properties such as tunable surface roughness, [10] surface chemical reactivity 11 , and Young's moduli ranging from 20 kPa to 3 GPa, [11,12] approaching the modulus of living tissue (10 kPa [13] ). However, the diversity of biological landscapes offered by the different human tissues, in terms of mechanical flexibility, interface functionalization, accessibility and biological activities defines sets of requirements so stringent that commonly for each tissue/organ coupling ad hoc devices and platforms have been developed. Hence, examining the three major human's body interfaces targeted by bioelectronics applications (skin, heart, and brain), this review focuses on the strategies that can be adopted by employing organic materials such as surface patterning, novel material synthesis and bio-functionalization in order to enhance tissue/organ-specific coupling performances. These aspects are investigated highlighting current and future main challenges and providing perspectives on the development of the next generation organic bioelectronics devices, thus envisioning systems that are: 1) able to adapt their interface in shape and size to comply with different curvilinear and hierarchical biological architectures and 2) combine sensing and stimulation to dynamically control biological functions for biomedical applications.

show abstract

“…Recording cellular activity at high spatiotemporal resolution from soft tissue/organ systems with microelectrodes is a critical component of many biomedical research and clinical applications, including basic physiology studies, investigations of disease, and the development of disease therapies. [1][2][3][4] Despite their tremendous impact on classic electrophysiological research, microelectrodes are unable to readout important functional parameters such as intracellular calcium dynamics, metabolic activity, or target specific cell types. In recent years, optical techniques such as high speed fluorescence imaging have been widely used to measure important cellular parameters (e.g., membrane potentials and intracellular calcium) and optogenetics has been used to manipulate cells or circuits with cell-type specificity through the incorporation of lightsensitive proteins.…”

Section: Introductionmentioning

confidence: 99%

Transparent and Stretchable Au–Ag Nanowire Recording Microelectrode Arrays

Chen

Nguyen

Kowalik

et al. 2023

Adv Materials Technologies

View full text Add to dashboard Cite

Transparent microelectrodes have received much attention from the biomedical community due to their unique advantages in concurrent crosstalk‐free electrical and optical interrogation of cell/tissue activity. Despite recent progress in constructing transparent microelectrodes, a major challenge is to simultaneously achieve desirable mechanical stretchability, optical transparency, electrochemical performance, and chemical stability for high‐fidelity, conformal, and stable interfacing with soft tissue/organ systems. To address this challenge, we have designed microelectrode arrays (MEAs) with gold‐coated silver nanowires (Au–Ag NWs) by combining technical advances in materials, fabrication, and mechanics. The Au coating improves both the chemical stability and electrochemical impedance of the Au–Ag NW microelectrodes with only slight changes in optical properties. The MEAs exhibit a high optical transparency >80% at 550 nm, a low normalized 1 kHz electrochemical impedance of 1.2–7.5 Ω cm2, stable chemical and electromechanical performance after exposure to oxygen plasma for 5 min, and cyclic stretching for 600 cycles at 20% strain, superior to other transparent microelectrode alternatives. The MEAs easily conform to curvilinear heart surfaces for colocalized electrophysiological and optical mapping of cardiac function. This work demonstrates that stretchable transparent metal nanowire MEAs are promising candidates for diverse biomedical science and engineering applications, particularly under mechanically dynamic conditions.

show abstract

Corrigendum to ‘Trends and recent development of the microelectrode arrays (MEAs)’ [Biosens. Bioelectr., 175: 112854]

Cited by 6 publications

References 0 publications

Advances in sensor developments for cell culture monitoring

Advances in sensor developments for cell culture monitoring

Conductive Polymer‐Based Bioelectronic Platforms toward Sustainable and Biointegrated Devices: A Journey from Skin to Brain across Human Body Interfaces

Transparent and Stretchable Au–Ag Nanowire Recording Microelectrode Arrays

Contact Info

Product

Resources

About