Corrigendum to “Th1 and Th2 indices of the immune response in pigs vaccinated against Taenia solium cysticercosis suggest various host immune strategies against the parasite” [Vet. Immunol. Immunopathol. 93 (2003) 81–90]

Díaz, María Alicia; Villalobos, Nelly; Aluja, Aline de; Rosas, Gabriela; Gómez-Conde, Eduardo; Hernández, Pablo E.; Larralde, Carlos; Sciutto, Edda; Fragoso, Gladis

doi:10.1016/j.vetimm.2004.09.023

Cited by 8 publications

(11 citation statements)

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“…Thus, genetic, immunological and hormonal factors have been related to resistance in this model [7][8][9][10][11]. Likewise, some of these observations have been confirmed in the natural hosts for T. solium [12,13].…”

Section: Taenia Crassiceps and Mesocestoides Corti Are Useful Experimmentioning

confidence: 78%

The Complex Role of Pro- and Anti-Inflammatory Cytokines in Cysticercosis:Immunological Lessons from Experimental and Natural Hosts

Terrazas¹

2008

CTMC

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Parasitic helminthes have developed complex mechanisms to evade or modulate hosts responses. Studies on cysticercosis are solid, but scarce. The most studied immunological models of cysticercosis are Taenia crassiceps infecting mice and T. solium infecting pigs. These parasites, despite being widely exposed to the host, are able to modulate the host immune system. Taenia metacestodes, much like other helminthes parasites, have developed complicated strategies in order to infect and successfully colonize their hosts. We focus here on the accumulated evidence from experimental models that have been helpful in analyzing and characterizing the host immune response to cysticercosis. Moreover, the mouse model has been used to design rationale vaccine strategies, some of them with promising results. We also discuss recent advances in understanding immune-regulation of cysticercosis. The parasite is able to manipulate the host immune system into supporting its survival by keeping a low inflammatory profile by causing the production of some cysticerci-released products that have immunomodulatory activities, as well as promoting the raise of alternatively activated macrophages. Finally, we delineate, according to recent literature, the likely pathway involved in protection and susceptibility against cysticercosis. As more aspects of the role of different immune and parasite-derived molecules are elucidated, better therapeutic targets may be identified to help treat cysticercosis.

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Section: Taenia Crassiceps and Mesocestoides Corti Are Useful Experimmentioning

confidence: 78%

The Complex Role of Pro- and Anti-Inflammatory Cytokines in Cysticercosis:Immunological Lessons from Experimental and Natural Hosts

Terrazas¹

2008

CTMC

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“…Most of the studies have focused on the evaluation of the antibody response induced and much less have been explored in their ability to damage the parasite [72]. Vaccines can also stimulate a specific cellular proliferative response with the production of inflammatory cytokines that could participate in controlling the installation as well as the development of the parasite [72]. However, the relevance of components of the cellular immunity in the resistant mediated by vaccination are even more scarcely explored, with a couple of exceptions [41,72].…”

Section: The S3pvac Vaccine and It Efficacy In Natural Conditions Of mentioning

confidence: 99%

“…It has been argued that vaccine-Abs may destroy T. solium oncospheres by fixing complement [55,79] but the vulnerability of these early larval phases of the parasite has not been explored yet. Later on, it was observed that vaccination of mice and pigs with a parasite epitope (GK1) induces the synthesis of antibodies that are capable of interfering with the cysticerci transformation into tapeworms in the intestines of hamsters [72,80]. It is argued that an exacerbated inflammatory response may also damage the larval stage of the parasite and/or interfere with the establishment of the cysticerci.…”

Section: Immunity and Vaccinationmentioning

confidence: 99%

“…It is argued that an exacerbated inflammatory response may also damage the larval stage of the parasite and/or interfere with the establishment of the cysticerci. However, up to date only the increased specific pro-inflammatory cytokines have been studied in the case of S3Pvac [41,72], but their relevance in parasite establishment and/or destruction has not been explored.…”

Section: Immunity and Vaccinationmentioning

confidence: 99%

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Vaccines Against Cysticercosis

Sciutto

Fragoso

Aluja³

et al. 2008

CTMC

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Taenia solium cysticercosis is a major parasitic disease that seriously and frequently affects human health and economy in undeveloped countries. Since pigs are an indispensable intermediate host, it is conceivable to curb transmission by reducing pig cysticercosis through their effective vaccination. This article reviews current knowledge on the development vaccines against porcine cysticercosis. It highlights the development of several versions of S3Pvac aimed to increase effectiveness, reduce costs and increase feasibility by novel delivery systems and alternative routes of administration.

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“…Firstly, vaccination of pigs with a tripartite vaccine developed from a T. crassiceps cDNA library (S3Pvac) reportedly induced 50% protection against T. solium infection and a 98% reduction in cysticerci burden (Huerta et al 2001). Following this study, S3Pvac was shown to induce elevated Th1 responses (IFN-γ) in vaccinated pigs while Th2 responses (IL-4 and IL-10) were unaffected (Díaz et al 2003) while elevated total IgG recognised one of the S3Pvac components and inhibited the development of the cysticerci to tapeworms, in a hamster model. Vaccines which skew the immune response to a Th1 response or increased Th1/Th2 ratio, therefore, may have great potential against cysticercosis in veterinary species and humans living in endemic regions.…”

Section: Taeniidaementioning

confidence: 94%

The immune response to parasitic helminths of veterinary importance and its potential manipulation for future vaccine control strategies

Foster

Elsheikha

2012

Parasitol Res

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Despite the increasing knowledge of the immunobiology and epidemiology of parasitic helminths of the gastrointestinal system and the cardiorespiratory system, complications arising from infections of animals and humans with these parasites are a major clinical and economic problem. This has been attributed to the high incidence of these parasites, the widespread emergence of multi-drug resistant parasite strains and the lack of effective vaccines. Efforts to develop and produce vaccines against virtually all helminths (with the exception of Dictyocaulus viviparus and some cestode species) have been hindered by the complexity of the host-parasite relationship, and incomplete understanding of the molecular and immune regulatory pathways associated with the development of protective immunity against helminths. Novel genomic and proteomic technologies have provided opportunities for the discovery and characterisation of effector mechanisms and molecules that govern the host-parasite interactions in these two body systems. Such knowledge provided clues on how appropriate and protective responses are elicited against helminths and, thus, may lead to the development of effective therapeutic strategies. Here, we review advances in the immune response to selected helminths of animal health significance, and subsequent vaccine potential. The topics addressed are important for understanding how helminths interact with host immune defences and also are relevant for understanding the pathogenesis of diseases caused by helminths.

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Corrigendum to “Th1 and Th2 indices of the immune response in pigs vaccinated against Taenia solium cysticercosis suggest various host immune strategies against the parasite” [Vet. Immunol. Immunopathol. 93 (2003) 81–90]

Cited by 8 publications

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The Complex Role of Pro- and Anti-Inflammatory Cytokines in Cysticercosis:Immunological Lessons from Experimental and Natural Hosts

The Complex Role of Pro- and Anti-Inflammatory Cytokines in Cysticercosis:Immunological Lessons from Experimental and Natural Hosts

Vaccines Against Cysticercosis

The immune response to parasitic helminths of veterinary importance and its potential manipulation for future vaccine control strategies

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