Corrigendum to “Sulfation of tea polysaccharides: Synthesis, characterization and hypoglycemic activity” [Int. J. Biol. Macromol. 46 (2010) 270–274]

Wang, Yuanfeng; Peng, Yonghua; Wei, Xinlin; Yang, Zhiwei; Xiao, Jianbo; Jin, Zhengyu

doi:10.1016/j.ijbiomac.2021.08.192

Cited by 6 publications

(9 citation statements)

References 3 publications

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“…Zhao ( 13 ) reported that the combination of hawthorn polyphenols, D-chiro-inositol, and ECG could improve insulin resistance and reduce fasting blood glucose and hepatic gluconeogenesis by downregulating PI3K/Akt/FOXO1-mediated PEPCK and G6-Pase and upregulating PI3K/Akt/GSK3-mediated hepatic glycogen synthase GS activation in the liver. Currently, extensive studies have been reported on tea extracts as glycoside hydrolases inhibitors, such as optimization of the extract preparation process, selection of extraction solvents, and comparison of inhibitory activity of different tea types and sources ( 14 – 16 ). Although catechin-containing tea extracts have been used as glycoside hydrolases inhibitors, few reports exist on purified catechin monomers as inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Structural changes and molecular mechanism study on the inhibitory activity of epigallocatechin against α-glucosidase and α-amylase

Man

Feng²,

Xiao³

et al. 2022

Front. Nutr.

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In this study, the inhibition and mechanism of epigallocatechin (EGC) on two key glycoside hydrolases (α-glucosidase, α-amylase) were explored from the molecular structure level. The chemical structure of EGC was characterized by X-ray diffraction, Fourier transform infrared (FTIR) spectroscopy, and proton nuclear magnetic resonance spectroscopy. EGC’s inhibition on these enzymes was colorimetrically determined. The effects of EGC on the chemical structure and spatial configuration of the enzymes were explored via FTIR spectroscopy, fluorescence spectroscopy, and molecular docking techniques. The results showed that EGC exhibited the inhibition of α-glucosidase and α-amylase in a non-competitive manner, showing a continuous upward trend as EGC’s concentration increased. There was a fluorescence quenching effect of EGC on α-glucosidase and α-amylase. Molecular docking confirmed that EGC can bind to amino acid residues in the enzyme through intermolecular hydrogen bonds and hydrophobic interactions, resulting in the changed chemical structure and spatial conformation of the enzymes. This decreased enzyme activity. This result suggested that EGC has the potential to inhibit two key glycoside hydrolases, and it would be beneficial to incorporate EGC into functional foods for diabetics.

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Section: Introductionmentioning

confidence: 99%

Structural changes and molecular mechanism study on the inhibitory activity of epigallocatechin against α-glucosidase and α-amylase

Man

Feng²,

Xiao³

et al. 2022

Front. Nutr.

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“…It has been reported that peach gum-derived polysaccharides significantly reduced postprandial blood glucose level in streptozotocin-induced diabetic rats. [22] Soy polysaccharide might attenuate the increase in postprandial glucagon and pancreatic polypeptide levels while increasing somatostatin levels, but showed no impact on plasma insulin levels. [23] The administration of Sargussum vulgare sulfated polysaccharides to diabetic rats resulted in good defence against the hepatotoxicity and nephrotoxicity of diabetes, in addition to correcting of glycemic and lipid parameters, as well as excellent antioxidant status and histological protection.…”

Section: Animal Postprandial Blood Glucose Testmentioning

confidence: 95%

Inhibition on α‐Amylase and α‐Glucosidase of Polysaccharides from Inonotus obliquus and Effects on Delaying the Digestion of Polysaccharides‐Dough system

et al. 2022

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In the present study, three alcohol precipitation polysaccharides fractions (IOP40, IOP60, and IOP80) are isolated from Inonotus obliquus polysaccharides (IOP). In vitro starch digestion experiments suggest that IOP40 and IOP60 show stronger inhibitory effects than crude polysaccharides. Inhibition kinetics demonstrates that IOP60 has reversible and anti-competitive inhibitory effect on 𝜶-glucosidase. I. obliquus polysaccharides also have a significantly effect on the digestion of dough. Furthermore, in vivo studies prove IOP60 can inhibit the increase in postprandial blood glucose level. IOP60 is further purified to gain IOP-2S. The results of monosaccharide composition show that IOP-2S consisted of mannose, rhamnose, glucose, galactose, xylose, and arabinose in Moorbys of 0.

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“…[ 73,74 ] (Figure 2b) Chitosan contains one amino group and two hydroxyl groups in its repeating glycosidic units, making it an ideal material for drug systems. [ 75 ] The in vitro drug release test demonstrated that the chitosan hydrogel had a continuous and controlled profile for the loaded drug and significantly reduced the inflammation and apoptosis of the spinal cord in SCI animals, which obviously improved tissue repair at the SCI lesions. [ 76 ] However, the solubility of chitosan polymers is limited by the presence of acidic fluids, which significantly limits the application of chitosan hydrogels.…”

Section: Hydrogel‐based Multimodal Strategy For Treating Scimentioning

confidence: 99%

Hydrogel and Nanomedicine‐Based Multimodal Therapeutic Strategies for Spinal Cord Injury

Yin,

Liang,

Han

et al. 2023

Small Methods

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Spinal cord injury (SCI) is a severe neurodegenerative disease caused by mechanical and biological factors, manifesting as a loss of motor and sensory functions. Inhibition of injury expansion and even reversal of injury in the acute damage stage of SCI are important strategies for treating this disease. Hydrogels and nanoparticle (NP)‐based drugs are the most effective, widely studied, and clinically valuable therapeutic strategies in the field of repair and regeneration. Hydrogels are 3D flow structures that fill the pathological gaps in SCI and provide a microenvironment similar to that of the spinal cord extracellular matrix for nerve cell regeneration. NP‐based drugs can easily penetrate the blood‐spinal cord barrier, target SCI lesions, and are noninvasive. Hydrogels and NPs as drug carriers can be loaded with various drugs and biological therapeutic factors for slow release in SCI lesions. They help drugs function more efficiently by exerting anti‐inflammatory, antioxidant, and nerve regeneration effects to promote the recovery of neurological function. In this review, the use of hydrogels and NPs as drug carriers and the role of both in the repair of SCI are discussed to provide a multimodal strategic reference for nerve repair and regeneration after SCI.

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Corrigendum to “Sulfation of tea polysaccharides: Synthesis, characterization and hypoglycemic activity” [Int. J. Biol. Macromol. 46 (2010) 270–274]

Cited by 6 publications

References 3 publications

Structural changes and molecular mechanism study on the inhibitory activity of epigallocatechin against α-glucosidase and α-amylase

Structural changes and molecular mechanism study on the inhibitory activity of epigallocatechin against α-glucosidase and α-amylase

Inhibition on α‐Amylase and α‐Glucosidase of Polysaccharides from Inonotus obliquus and Effects on Delaying the Digestion of Polysaccharides‐Dough system

Hydrogel and Nanomedicine‐Based Multimodal Therapeutic Strategies for Spinal Cord Injury

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